DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	141/502 - (28%)
Similarity:	231/502 - (46%)	Gaps:	66/502 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLI 67
            |.:..:|...||.|.|....|....:....|.||...|::|::  |.|.....:...|..::  :
  Fly     2 LTINLLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSS--LENIITYKRKLSFRTKY--L 62

  Fly    68 AEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKN-NLYSLLVNWLGDGLLISQGKKWFRRR 131
            .::|..|.|.|......:|.|.|::|.|.||.....|: ::.:.:.:.:|:|||..|...|..||
  Fly    63 NKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRR 127

  Fly   132 KIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKI-- 194
            |...|:|...:|..|..:||.::..:: .|.|....|..|::.|.....:..|.|:|.||.::
  Fly   128 KHFNPSFKQDLLLSFFHIFDAETKVLM-NLLDTYVDKGEIDVVPEMLRWSFKIAAQTTMGSEVKH 191

  Fly   195 -----NAQLQPQFTYVQSVTTASAML---AERFMNPL-----QRLDFTMKLFYPKLLD-----KL 241
                 |..|...|..:.|.:|.:.::   ..|.::.:     .|.|...::  .|:||     |:
  Fly   192 DEHFKNGSLVESFESLISHSTLNILMPLVQNRMISKICGYDKLRADNFSRI--QKMLDNVVNKKV 254

  Fly   242 NDAVKNMHD-FTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSN 305
            |...|...| .:|.||....||.:|     ||                              ::.
  Fly   255 NPLPKTDSDPESNIVINRAMELYRK-----GD------------------------------ITY 284

  Fly   306 DDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKY 370
            .|::.|....:..|:||:..::....:|||.|||.|..||:|:..|..|.....:|...:.:|.|
  Fly   285 MDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDY 349

  Fly   371 LECVIKESLRLFPSVPIIGRYISQDTVL-DGKLIPADSNVIILIYHAQRDPDYF-PDPEKFIPDR 433
            ||.||||:|||.|::||..|....|..| :|.|||....:.|.::|..|:|:.: ||.:.|.||.
  Fly   350 LERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDN 414

  Fly   434 FSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFEL 480
            |..|...:..|:||.||:.|.|||||.|:||:..|..:.:::|::::
  Fly   415 FLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	133/471 (28%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	133/471 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	5	4.860