DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	127/484 - (26%)
Similarity:	223/484 - (46%)	Gaps:	54/484 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAEFGKNIKTQM 78
            |.|.|....|.........|.||..||::|.|..|:.     :..|.:.....:.:.|..| ...
  Fly    13 LLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMR-----REDILNAFGCFLDKHGPTI-FSW 71

  Fly    79 LGESGFM-TADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWFRRRKIITPAFHFKI 142
            ||...|| .:|.::::.|.:|...:.|..:|..:.:..|.||...:..:|...||::.|||..|:
  Fly    72 LGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHRKLLNPAFGHKV 136

  Fly   143 LEDFVEVFDQQSATMVQKLYD-RADGKTVINMFPVACLCAMDIIAETAMGVKI--------NAQL 198
            |..|:.:|::::|.::.:|.. :.||:.  ::.|:.....:.|..:|.||..:        |:.|
  Fly   137 LLSFLPIFNRETALLLDQLEPLQDDGEK--DLIPLLQSFTLGIATQTTMGSDVKDEESFRSNSLL 199

  Fly   199 QPQFTYVQSVTTA--SAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVITERRE 261
            ......::::|..  |..|..||...|                    |.|..|.:  ...||.|:
  Fly   200 GRYQCILETMTDMCFSPWLNSRFCRQL--------------------AGKESHYY--QAKTEIRQ 242

  Fly   262 LLQKAIAD--GGDADAALLNDVGQKRRMAL---LDVLLKSTIDGAPLSNDDIREEVDTFMFEGHD 321
            .::|.|..  ..|...||.:.....:.:.|   .|::.:...   .|.|  :.:|.:..:|...:
  Fly   243 FIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVF---TLKN--VEDESNIIVFGAFE 302

  Fly   322 TTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVP 386
            ||.:::.:|..|||..||.|.|.|:|::.:..:.....|:.....::.||:.::.||:|:.|.||
  Fly   303 TTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVP 367

  Fly   387 IIGRYISQDTVL-DGKLIPADSNVIILIYHAQRDPDYF-PDPEKFIPDRFSMERKGEISPFAYTP 449
            ::.|..|||..| :|.::|....:.|.|||..|....: ||.|.|.||.|......:..|:||.|
  Fly   368 VVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIP 432

  Fly   450 FSAGPRNCIGQKFAMLEMKSTISKMVRHF 478
            |:.|.|||||.::|::..|.|::|::|::
  Fly   433 FTKGIRNCIGWRYALISAKVTLAKLLRNY 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	122/464 (26%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	122/464 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860