DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and Cyp313a3

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	138/493 - (27%)
Similarity:	232/493 - (47%)	Gaps:	53/493 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LELFAILLATALA-WDYMRKRRHNKMYAEAGIRGPKSYPLVGNA-PLLINESPKSKSSIFDMQFR 65
            ::.|.:|||..:. |.|....|.........|.||...|::|.| ..||  :.|.|.||   :.:
  Fly     1 MDTFQLLLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGLPILGIAFEYLI--TYKRKMSI---RTK 60

  Fly    66 LIAEFGKNIKTQMLGESGF-MTADSKMIEAIMSSQQTIQKNNLYSLLVN-WLGDGLLISQGKKWF 128
            .:..:|..... .:|.:.| :|.|.|:.|.|..|.:.:.:::::|..|| ..|||||..:..||.
  Fly    61 YMDIYGSTCLV-WVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVNSCTGDGLLSLEASKWV 124

  Fly   129 RRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMG-- 191
            .|||.:.|||...:|..|:.:|:.::.|:|..| |...|:....:.......:..|..:|.:|
  Fly   125 DRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFL-DSLVGQGEKKVRDDIVRWSFRIATQTTVGTD 188

  Fly   192 VKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLND-------AVKNMH 249
            ||.:|..:.. :.::|..|...::.   ||.|  |.||    :.|:...|..       |..|::
  Fly   189 VKKDASFKND-SVLKSYETFMKIIV---MNVL--LPFT----HNKIFSTLGGFETQKALAKSNVN 243

  Fly   250 DFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDT 314
            ....:::.  ::|:.|..:.......:::|...:..|             ...:|.::::.|..:
  Fly   244 KMIGTIVD--KKLMTKPESGSQPEITSVINKAIELHR-------------NGEMSREEVQSECCS 293

  Fly   315 FMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRD---VIGDDKSAPVTMKLLGELKYLECVIK 376
            |:....:||..::.....|||..||.|..|:||:::   |.||.:   ||...|..:.:||.|:.
  Fly   294 FVVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGDFE---VTYDDLQRMVFLERVVN 355

  Fly   377 ESLRLFPSVPIIGRYISQDTVL-DGKLIPADSNVIILIYHAQRDPDYF-PDPEKFIPDRFSMERK 439
            |:|||.||||...|...:|..| .|.:||....:.|.|:...|:.|:: .||..|.||.|..:..
  Fly   356 ETLRLIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNV 420

  Fly   440 GEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRH 477
            .:..|:||.|||.|.|||||.|:.::..|..:||::|:
  Fly   421 RDRHPYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRN 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	130/461 (28%)
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	130/461 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860