DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	160/508 - (31%)
Similarity:	268/508 - (52%)	Gaps:	38/508 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAE 69
            |..:.|:..|.:.:.|:.|.:::..:  ...|.:.|.:|:..:|.               :|:..
  Fly     8 LLLLALSLYLLYVFERQSRIDRLTHK--WPAPPALPFIGHLHILA---------------KLVGP 55

  Fly    70 FGKNIKTQMLGES--------------GFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLL 120
            ......|:|:.|.              ..:..:.|.|:|:.|:||.:||.|.|.:..|||.:||.
  Fly    56 HPLRRATEMINEHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLF 120

  Fly   121 ISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDII 185
            .|..:||..||||:.|||::.:::.||.||::||..::..:...|:....|:...:.....:|.|
  Fly   121 TSGFEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTI 185

  Fly   186 AETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHD 250
            .|||:||.:.:|...:..|:.:|.:...::.:|..|...|..|..|  ......:..:.:|.:|.
  Fly   186 CETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFK--RTSHYKREQELIKTLHG 248

  Fly   251 FTNSVITER-RELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKST-IDGAPLSNDDIREEVD 313
            ||..:|.:| .|:.|.|......:..|.|:  |.||.:..||.||.|. .||.||:..|||||||
  Fly   249 FTEGIIQKRIDEINQDAENRNYQSSDAELD--GVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVD 311

  Fly   314 TFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKES 378
            |.:|.|.|.|.:::.|..|.:..|||.|.|..:||..|.|.|||.|::::.:.:|::||..|||:
  Fly   312 TIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKET 376

  Fly   379 LRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEIS 443
            ||::||.|:..|..:.:..::...||..|:|||...:..|..|:||||..|.|||:::..:.:|.
  Fly   377 LRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIE 441

  Fly   444 PFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGE-EVQPVLNVIL 495
            ...:.||.||.|:|:||::||:.:|..::.::|:|...|||| :|:..||.::
  Fly   442 ATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	153/471 (32%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	155/479 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449059
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100859
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.790