DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	238/523 - (45%)
Similarity:	334/523 - (63%)	Gaps:	36/523 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYLELFAILLATALAW-------DYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSS 58
            |.|.|..:||..| .|       |..||        .|.:.||...||:|...|::..:||   :
  Fly     1 MLLFLLVVLLFGA-GWIIHLGQADRRRK--------VANLPGPICPPLIGAMQLMLRLNPK---T 53

  Fly    59 IFDMQFRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQ 123
            ...:....:.:||...:..:......|:.|:::.|.::|||:.:.|:.:|.:|..|||:|||:|.
  Fly    54 FIKVGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSD 118

  Fly   124 GKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAET 188
            ||.|.:|||||||.|||.|||.|||||||||...||:|..:|:|.| .:::...|..|:||||||
  Fly   119 GKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNT-FDVYRSICAAALDIIAET 182

  Fly   189 AMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTN 253
            |||.||.||......|.::|...:|:|:.|||:...:::....|.:|.|..:....::.|.:||.
  Fly   183 AMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTI 247

  Fly   254 SVITERRELL---QKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDTF 315
            .||.:||:.|   |..:.|..|      .|||.|||||||||||.||:||.||:||:||||||||
  Fly   248 KVIEKRRQALEDQQSKLMDTAD------EDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTF 306

  Fly   316 MFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLR 380
            ||||||||||:::|..:.|:|||||||::.:|:..|:|.|:|.||:::.||||||:|||||||||
  Fly   307 MFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLR 371

  Fly   381 LFPSVPIIGRYISQD-----TVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKG 440
            ::|.|||:||.:..|     :|....:|||.|.:||.|:...|.|:.||:|::|||:|.  |...
  Fly   372 MYPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--ENGS 434

  Fly   441 EISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNVILRSTTGINCGL 505
            .::||...|||||||||||||||.||||..::|:||.:||||:|:.|:.::|::|||.||...|:
  Fly   435 RVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIVNIVLRSETGFQLGM 499

  Fly   506 KPR 508
            :.|
  Fly   500 RKR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	219/462 (47%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	216/439 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449005
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	10.010