DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp316a1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_648129.2	Gene:	Cyp316a1 / 38840	FlyBaseID:	FBgn0035790	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	131/518 - (25%)
Similarity:	246/518 - (47%)	Gaps:	44/518 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYLELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFR 65
            |.|....|....|.|::|.|.||...:.  ..::||.::||:|....|:..:|   .:.|.....
  Fly     1 MILTATFICFCLASAFNYFRARRQRSLI--KNLKGPFTWPLMGAMHKLLFLTP---INFFQRSTE 60

  Fly    66 LIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWFRR 130
            .:.::|...:..:........||.::...::.:...::..  |.|:.:||..|:|:.|.::|.:|
  Fly    61 YLTKYGTFSRCWVFHRLFIPLADLELSRQLLENDTHLETG--YELMKDWLVGGVLMCQSEQWQKR 123

  Fly   131 RKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKIN 195
            ..:|:..|....||..:::...|:..::|||..:||.| |.:::.......:|::..|..|.|
  Fly   124 HSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQADQK-VFDIWYTVSPIVLDLMVMTTCGAK-- 185

  Fly   196 AQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVITERR 260
                |...|.:::...|.:..:||::......|...|..|.:..:.|..:|.::|..|:::...:
  Fly   186 ----PSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDEHNNLMAMHQ 246

  Fly   261 ELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDTFMFEGHDTTTS 325
            ...|..|.:|  .|...|..:..|...:||::||:|  ....|:.::|..|::|..:.|:...:.
  Fly   247 SQNQLKIENG--LDIYQLRPIPLKDHKSLLEILLES--KDPQLTGEEICGELNTCNYLGYQLCSP 307

  Fly   326 SIAFTCYLLARHPEVQARVFQE-----VRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSV 385
            ::.|....:||:|.||.:...|     ::|...|          |.:|.||:.|:.|::||:|..
  Fly   308 ALCFCLVTIARNPSVQQKCLDELNLAQIKDQGWD----------LEKLNYLDAVLHETMRLYPPQ 362

  Fly   386 PIIGRYISQD-----TVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISPF 445
            .|:||.:.:|     :::....:|..|.:.|.:|..||:...:|....|...||.      .||.
  Fly   363 VIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFL------DSPP 421

  Fly   446 AYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNVILRSTTGINCGLKPR 508
            ....:|.|||.|..:||:|..:|:.::.::.:||:||.|:||:..|.::|.|:.|....||||
  Fly   422 ELLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLRLVLGSSNGFQLALKPR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	114/464 (25%)
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	114/464 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.970