DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	126/536 - (23%)
Similarity:	228/536 - (42%)	Gaps:	76/536 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLI----NESPKSKS--SIFDMQFR 65
            |:.|...|.:...||..:.|.         :..|.|  ||.||    .|..|:|:  .||...:.
  Fly    11 AVALLAILTYYIHRKLTYFKR---------RGIPFV--APHLIRGNMEELQKTKNIHEIFQDHYN 64

  Fly    66 LIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQ-------KNNLYSLLVNWLGDGLLISQ 123
            ...|    .|...:|...|.:..:.:|:..::.|..|:       |...|:...:.:...|....
  Fly    65 KFRE----SKAPFVGFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLD 125

  Fly   124 GKKWFRRRKIITPAF---HFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDII 185
            |.:|...|..::..|   ..|::...|.....:..|:   ::::....:|:.:..:.....:|:|
  Fly   126 GAQWRLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTV---MHEKVPKNSVLEIRDLVARFTVDVI 187

  Fly   186 AETAMGVKINA--QLQPQFTYV---QSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLN--D 243
            ...|.|::.|:  ..:.:|.|.   ..|......|...||..           ||||..||.  .
  Fly   188 GTCAFGIQCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRS-----------YPKLARKLGMVR 241

  Fly   244 AVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAP----LS 304
            ...::.:|.:.::||...:.:|......|....|:....||          :.|::...    |:
  Fly   242 TAPHIQEFYSRIVTETVAVREKEHIKRNDFMDMLIELKNQK----------EMTLENGDVVRGLT 296

  Fly   305 NDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELK 369
            .:::..:...|...|.:|::|::.|..|.||::|::|.:|..||.:|| :......|.:...:||
  Fly   297 MEEVLAQAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVI-EQHDQNFTYECTKDLK 360

  Fly   370 YLECVIKESLRLFPSVPIIGRYISQDTVLDGK---LIPADSNVII---LIYHAQRDPDYFPDPEK 428
            ||..|:.|:|||:..||.:.|..::..|:.|.   :|.|..:|||   .|:|   ||..:|:|.:
  Fly   361 YLNQVLDETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHH---DPSIYPEPFE 422

  Fly   429 FIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNV 493
            |.|:|||.|........|:.||..|||||||.:|..::.:..::.::|:|:.....:...|::..
  Fly   423 FRPERFSPEESAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPLVYD 487

  Fly   494 ILRSTTGINCGLKPRV 509
            ......|:..|:..:|
  Fly   488 PKSFVLGVKDGIYLKV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	116/487 (24%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	116/495 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910