Protein Alignment Cyp4d14 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001386630.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 523
• Identity: 140/523 - (26%)
• Similarity: 256/523 - (48%)
• Gaps: 65/523 - (12%)

  Fly     7 AILLATALAWDYMRKRRHNKMYAEAGIRGP--KSYPLVGNAPLLINESPKSKSSIFDMQFRLIAE 69
            |:|||..|...::.:.|....:    |.||  .|: |:|:.|....:.......:.|:......:
  Rat    11 AVLLAFGLCCTFVHRARSRYEH----IPGPPRPSF-LLGHLPYFWKKDEACGRVLQDVFLDWAKK 70

  Fly    70 FGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGL----LISQGK--KWF 128
            :|..::..:..::..:....:.::..:.|.:..:.:.:|..:....|:.|    |:|:..  :|:
  Rat    71 YGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRAIQTVFGERLFGQGLVSECDYGRWY 135

  Fly   129 RRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVK 193
            ::|:::..||....|...:..|::::..:::.|..:|||:|.::|..:.....:||:|:.|.|::
  Rat   136 KQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAKADGQTPVSMQDMLTCATIDILAKAAFGME 200

  Fly   194 INAQLQPQFTYVQSV------TTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFT 252
            .:..|..|....|:|      .:||.....:|| |.:|          |.|.::.::::.:....
  Rat   201 TSMLLGAQKPLSQAVKVMLEGISASRNTLAKFM-PGKR----------KQLREIRESIRLLRQVG 254

  Fly   253 NSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDD--IREEVDTF 315
            ...:..|||.|::    |.|..|.:|..:            ||:. :||   .||  :.:...||
  Rat   255 KDWVQRRREALKR----GEDVPADILTQI------------LKAE-EGA---QDDEVLLDNFVTF 299

  Fly   316 MFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLR 380
            ...||:|:.:.:|||...|:|.||:.||:..||.:|:|..:.  :..:.||.|:||..|:|||||
  Rat   300 FIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH--LDYEDLGRLQYLSQVLKESLR 362

  Fly   381 LFPSVPIIG--RYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEIS 443
            |:|  |..|  |.:.::|::||..:|.::.::...|...|...||.||..|.||||.   .|...
  Rat   363 LYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG---PGAPK 422

  Fly   444 P-FAYTPFSAGPRNCIGQKFAMLEMKSTISKMVR--HFELLPLGEEVQPVLNVILRSTTGINCGL 505
            | |.|.|||.|.|:||||:||.:|:|..::|:::  .|.|:| |:.........|:....:.|.|
  Rat   423 PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP-GQRFGLQEQATLKPLDPVLCTL 486

  Fly   506 KPR 508
            :||
  Rat   487 RPR 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	122/450 (27%)
Cyp46a1	NP_001386630.1	CYP46A1-like	61..484	CDD:410706	123/461 (27%)