DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and Cyp4d21

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_609129.2	Gene:	Cyp4d21 / 34036	FlyBaseID:	FBgn0031925	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	226/516 - (43%)
Similarity:	330/516 - (63%)	Gaps:	17/516 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYLELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFR 65
            |::.|...:|...|.||..||:.....:.::.|.||.:.|:|||....:...|::....|...|.
  Fly     1 MWILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYFN 65

  Fly    66 LIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWFRR 130
               ::||..:..:|||....|.|.|..|:|:||...::|.:||..|.::||||||:|.|.||..|
  Fly    66 ---KYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSR 127

  Fly   131 RKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKIN 195
            ||::.||||||.||:|||:.|:.|..||:||.:.|||||.:::|....|.|:|:..||||||::|
  Fly   128 RKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVN 192

  Fly   196 AQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVITERR 260
            ||.:|.|.|.:::.:...:.::|..:...|.::...|..|.:..:|...:..|.|||:.||.|||
  Fly   193 AQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERR 257

  Fly   261 ELLQKAIADG-------GDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDTFMFE 318
            .:|::|.|||       ||      :|:|.|.:|.|||:||::|||..|||:.|||||||.|:|.
  Fly   258 AILERARADGTYKPLIMGD------DDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFA 316

  Fly   319 GHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFP 383
            |.|||||.::...:.::|||:||..:::|:..|:|.|..|.||...|.|||||:|||||::||.|
  Fly   317 GDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHP 381

  Fly   384 SVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRF-SMERKGEISPFAY 447
            .|||:||||.:|..:....||.:::::::.|:..|||:|||||..|.|:|: .|:......|.||
  Fly   382 PVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAY 446

  Fly   448 TPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVLNVILRSTTGINCGLKPR 508
            .|||:||:||||||||.|:||:.|||::||:||||||.:::.....||.|:||.|.|||||
  Fly   447 IPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFILSSSTGNNVGLKPR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	206/462 (45%)
Cyp4d21	NP_609129.2	p450	35..482	CDD:278495	203/455 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448998
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	1	1.000	-	-		H82150
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	12	11.910