DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	161/516 - (31%)
Similarity:	270/516 - (52%)	Gaps:	55/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLI 67
            :.|:.:||.|...|..:||  ...:...:.:.||.::||:|||.::....|:   .||.:...|.
  Fly     1 MALWPLLLITLTIWILVRK--WTLLRLGSSLPGPWAFPLLGNAQMVGKLRPE---YIFLVFTELR 60

  Fly    68 AEFGKNIKTQMLGES--GFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWFRR 130
            ..||...:.: ||..  .|:.:..:..:|:  ...|::|.:.:..|...:|:|||||.|..|.|:
  Fly    61 DRFGATYRLR-LGPQLWVFLHSAEETRQAL--HDPTLRKADTFMQLEPLIGNGLLISHGAHWTRQ 122

  Fly   131 RKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKT---VINMFPVACLCAMDIIAETAMGV 192
            |:::||||..::|..|..........:|.:|     |.|   .:.:......|.:|.|.:|:||.
  Fly   123 RRLLTPAFQPQLLRSFAPAIGGHVERLVGRL-----GATRGAFLEVTEPLFACLLDAIVDTSMGA 182

  Fly   193 KINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVIT 257
            :::.|.......:|:...:|.:|.:|.:|||...|:..:  ..:|...|::.::.:|....|||.
  Fly   183 QLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQ--RTQLWRDLDEQLQVIHSQMESVIE 245

  Fly   258 ER-RELLQKAIADGGDADAALLNDVGQK--RRMALLDVLLKSTIDGAPLSNDDIREEVDTFMFEG 319
            :| :|||                |:|:.  |...|||.||.:..:|..||..:||:|::||:|.|
  Fly   246 KRAKELL----------------DMGEPAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFVFAG 294

  Fly   320 HDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPS 384
            .||||::::|..|.||:.||.|.|:.:|::||..|:.:   .:..|..|.|||.:|||.|||:..
  Fly   295 VDTTTAAMSFVLYALAKFPETQTRLRKELQDVALDETT---DLDALNGLPYLEALIKEVLRLYTI 356

  Fly   385 VPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISP--FAY 447
            ||..||..:|.|.:.|:...|...:.|.:|....|.:|:|||..|.|:|: :...|.::|  |:|
  Fly   357 VPTTGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERW-LPEDGAVAPPAFSY 420

  Fly   448 TPFSAGPRNCIGQKFAMLEMKSTISKMVRHFEL------LPLGEEVQPVLNVILRSTTGIN 502
            .|||.||..|||:::::|.||...:::||.|::      .||..|.|    ::|::..|||
  Fly   421 IPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQ----MVLKAQQGIN 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	149/470 (32%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	154/485 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100859
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	8.860