DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	183/538 - (34%)
Similarity:	277/538 - (51%)	Gaps:	40/538 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYLELFAILLATALAWDYMRKRRHNKMY-AEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQF 64
            |...|...|:|.|| ::|.  ||:::.| ..|.|..|...|::|.|.:   .:..|.:.|..:..
  Fly    27 MLTTLVGTLVAMAL-YEYW--RRNSREYRMVANIPSPPELPILGQAHV---AAGLSNAEILAVGL 85

  Fly    65 RLIAEFGKNIKTQMLGE--SGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKW 127
            ..:.::|:.:|. .||.  ..|:|..|. ||.|:|..|.:.|...|.....|.|||||||.|..|
  Fly    86 GYLNKYGETMKA-WLGNVLLVFLTNPSD-IELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHW 148

  Fly   128 FRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGV 192
            ...||:|.|.||..||:.||..|...|..:|.::...| ||: .::........:||:..|||||
  Fly   149 RHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA-GKS-FDVHDYMSQTTVDILLSTAMGV 211

  Fly   193 KINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVIT 257
            |...:....|.|.|:|.....::.:|.:..|.|||...|  :.||.:|.:..:..:...|:.|:.
  Fly   212 KKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYK--FTKLREKGDRMMNIILGMTSKVVK 274

  Fly   258 ERRELLQ---KAIAD-----------------GGDADAALLNDVGQKRRMALLDVLLKSTID-GA 301
            :|:|..|   :||.:                 ..|.|....||||.|||:||||.:::...: ..
  Fly   275 DRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDI 339

  Fly   302 PLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLG 366
            ..:..||.:||:|.||||||||::..:|...::..|.::||:||.|.:.:.||:.....|.....
  Fly   340 EWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTM 404

  Fly   367 ELKYLECVIKESLRLFPSVPIIGRYISQDTVLDG--KLIPADSNVIILIYHAQRDPDYFPDPEKF 429
            |:||||.||.|:|||:|.||:|.|.:..|..|..  ..:|..:.||:|.|...|.||.:|:|.||
  Fly   405 EMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKF 469

  Fly   430 IPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVL--N 492
            .||.|..||......:::.|||||||:|:|:|:|||::|..:|.:||::.:.....|....|  :
  Fly   470 DPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQAD 534

  Fly   493 VILRSTTGINCGLKPRVY 510
            :||:...|.|..|:.|.|
  Fly   535 IILKLENGFNVSLEKRQY 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	163/479 (34%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	162/468 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070