DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and cyp19a1a

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_571229.3	Gene:	cyp19a1a / 30390	ZFINID:	ZDB-GENE-990415-43	Length:	517	Species:	Danio rerio

Alignment Length:	537	Identity:	117/537 - (21%)
Similarity:	222/537 - (41%)	Gaps:	109/537 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLL-----INESPKSKSSIFDM 62
            |.|..:|||.          ||::.: ::.|.||..:  .|..|::     |.....:.|:.::
Zfish    48 LLLLCLLLAI----------RHHRPH-KSHIPGPSFF--FGLGPVVSYCRFIWSGIGTASNYYN- 98

  Fly    63 QFRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYS------LLVNWLG---DG 118
                 :::|..::..:.||...:.:.|..:..::       :.:||:      |.:..:|   .|
Zfish    99 -----SKYGDIVRVWINGEETLILSRSSAVYHVL-------RKSLYTSRFGSKLGLQCIGMHEQG 151

  Fly   119 LLI-SQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAM 182
            ::. |....|.:.|.....|.....|:..:|:....:.:.:..|....|.:..:::..:.....:
Zfish   152 IIFNSNVALWKKVRAFYAKALTGPGLQRTMEICTTSTNSHLDDLSQLTDAQGQLDILNLLRCIVV 216

  Fly   183 DIIAETAMGVKINAQ--LQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAV 245
            |:.....:||.:|..  ||....|..:..|........|     |||:..|. :.:...:|.||:
Zfish   217 DVSNRLFLGVPLNEHDLLQKIHKYFDTWQTVLIKPDVYF-----RLDWLHKK-HKRDAQELQDAI 275

  Fly   246 KNMHDFTNSVITERRELLQKAIADGGD-----ADAALLNDVGQKRRMALLDVLLKSTIDGAPLSN 305
                    :.:.|::: :|.|.|:..|     |:.......|:                   ||.
Zfish   276 --------TALIEQKK-VQLAHAEKLDHLDFTAELIFAQSHGE-------------------LSA 312

  Fly   306 DDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKY 370
            :::|:.|...:....||.:.|:.|...||.::|:|:.::.||:..|:....   :....|.:|:.
Zfish   313 ENVRQCVLEMVIAAPDTLSISLFFMLLLLKQNPDVELKILQEMDSVLAGQS---LQHSHLSKLQI 374

  Fly   371 LECVIKESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFS 435
            ||..|.||||..|.|....|....|.|::|..:...:|:|:.:....|. ::|..|.:|..|.|
Zfish   375 LESFINESLRFHPVVDFTMRRALDDDVIEGYNVKKGTNIILNVGRMHRS-EFFSKPNQFSLDNF- 437

  Fly   436 MERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLG----EEV--------Q 488
              .|...|.| :.||.:|||:|:|:..||:.|||.:..::..|.:.|:.    |.:        |
Zfish   438 --HKNVPSRF-FQPFGSGPRSCVGKHIAMVMMKSILVALLSRFSVCPMKACTVENIPQTNNLSQQ 499

  Fly   489 PV-------LNVILRST 498
            ||       :.:|||:|
Zfish   500 PVEEPSSLSVQLILRNT 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	102/488 (21%)
cyp19a1a	NP_571229.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589898
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950