DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and cyp26a1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_571221.2	Gene:	cyp26a1 / 30381	ZFINID:	ZDB-GENE-990415-44	Length:	492	Species:	Danio rerio

Alignment Length:	522	Identity:	129/522 - (24%)
Similarity:	215/522 - (41%)	Gaps:	83/522 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILLATALAWDYMRKRRHNKMYAEAGIRGP-----KSYPLVGNAPLLINESPKSKSSIFDMQFRLI 67
            :.||....|:.:..||     .:...|.|     ...|.:|....||.:..|     |....|
Zfish    20 LFLAAVKLWEMLMIRR-----VDPNCRSPLPPGTMGLPFIGETLQLILQRRK-----FLRMKR-- 72

  Fly    68 AEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNW-------LG-DGLLISQG 124
            .::|...||.:.|........:..:..|:..:..:       :.|.|       || |.|....|
Zfish    73 QKYGCIYKTHLFGNPTVRVMGADNVRQILLGEHKL-------VSVQWPASVRTILGSDTLSNVHG 130

  Fly   125 KKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVIN------MFPVACLCAMD 183
            .:...::|.|..||....||.::.|..|:..:.:|:...: |...::.      ||.:|
Zfish   131 VQHKNKKKAIMRAFSRDALEHYIPVIQQEVKSAIQEWLQK-DSCVLVYPEMKKLMFRIA------ 188

  Fly   184 IIAETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNM 248
                    ::|....:|     :.:.|....|.|.|...::.| |::.:..|  ...|...:: .
Zfish   189 --------MRILLGFEP-----EQIKTDEQELVEAFEEMIKNL-FSLPIDVP--FSGLYRGLR-A 236

  Fly   249 HDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVD 313
            .:|.:|.|.|.   ::|.|.|..       |:..||.:.||..::..|.....|.|...::|...
Zfish   237 RNFIHSKIEEN---IRKKIQDDD-------NENEQKYKDALQLLIENSRRSDEPFSLQAMKEAAT 291

  Fly   314 TFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAP---VTMKLLGELKYLECVI 375
            ..:|.||:||.|:.......|..:.||..:|.:||::.:......|   ::|:||.:|||..|||
Zfish   292 ELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVQEKVEMGMYTPGKGLSMELLDQLKYTGCVI 356

  Fly   376 KESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKG 440
            ||:||:.|.||...|...:...|:|..||...|||..|.......|.||:.::|.|:||..:...
Zfish   357 KETLRINPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADVFPNKDEFQPERFMSKGLE 421

  Fly   441 EISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFE--------LLPLGEEVQPVLNVILRS 497
            :.|.|.|.||..|.|.|:|::||.:.:|..:.::.:|..        .:..|..|.||.|:..:.
Zfish   422 DGSRFNYIPFGGGSRMCVGKEFAKVLLKIFLVELTQHCNWILSNGPPTMKTGPTVYPVDNLPTKF 486

  Fly   498 TT 499
            |:
Zfish   487 TS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	120/484 (25%)
cyp26a1	NP_571221.2	p450	14..487	CDD:299894	128/519 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910