Protein Alignment Cyp4d14 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 210/530 - (39%)
• Similarity: 296/530 - (55%)
• Gaps: 60/530 - (11%)

  Fly     1 MYLELFAILLATALAWDYMRKRRHNKMYAEAGIRGP-----KSYPLVGNAPLLINESPKSKSSIF 60
            :.|.|...:.:.|..|..||               |     ::|||||:|.|:   .|..:..
Human    29 LVLSLLQRVASYARKWQQMR---------------PIPTVARAYPLVGHALLM---KPDGREF-- 73

  Fly    61 DMQFRLIAEFGKNIKTQML-----GESGFMTA-DSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGL 119
               |:.|.|:.:..:...|     |....:.. :::.:|.|::|.:.|.|:::|..|..|||.||
Human    74 ---FQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGL 135

  Fly   120 LISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDI 184
            |.|.|.||..|||::||.|||.|||||:::.::|:..:|:|| ::...:...|.|....|||:||
Human   136 LTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL-EKHINQEAFNCFFYITLCALDI 199

  Fly   185 IAETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMH 249
            |.|||||..|.||......||::|...|.|:..|...|...||....:|......|  .:::.:|
Human   200 ICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHK--KSLQILH 262

  Fly   250 DFTNSVITERRELL---QKAIADG-GDADAALLNDVGQKRRMALLDVLLKSTID-GAPLSNDDIR 309
            .||||||.||...:   :....|| |.|.:       :.:|.|.||:||..|.| |..||::|||
Human   263 TFTNSVIAERANEMNANEDCRGDGRGSAPS-------KNKRRAFLDLLLSVTDDEGNRLSHEDIR 320

  Fly   310 EEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECV 374
            ||||||||||||||.::|.::.|||..:||||.:|..|:.||.| ....|.|::.|.:|:|||||
Human   321 EEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFG-KSDRPATVEDLKKLRYLECV 384

  Fly   375 IKESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERK 439
            |||:||||||||:..|.:|:|..:.|..:...:..:|:.|...|||.|||:||:|.|:||..|..
Human   385 IKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENA 449

  Fly   440 GEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHF------ELLPLGEEVQPVLNVILRST 498
            ....|:||.|||||||||||||||::|.|:.:|.::|||      :...||.|.|    :|||.:
Human   450 QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQ----LILRPS 510

  Fly   499 TGINCGLKPR 508
            .||...||.|
Human   511 NGIWIKLKRR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	189/448 (42%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	191/453 (42%)