Protein Alignment Cyp4d14 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 139/407 - (34%)
• Similarity: 215/407 - (52%)
• Gaps: 38/407 - (9%)

  Fly   115 LGDGLLISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMV---QKLYDRADGKTVINMFPV 176
            ||.||....|.|||:.|:::||.|||.||:.::||.......|:   :|:....|  |.:.::..
Human   121 LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQD--TSVEVYEH 183

  Fly   177 ACLCAMDIIAETAMGVKINAQLQPQF-TYVQSVTTASAMLAERFMNPLQRLDFTMKLF-----YP 235
            ....::|||.:.|...:.|.|..... .|.:::...|.::..|..:.|...|...||.     :.
Human   184 INSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 248

  Fly   236 KLLDKLNDAVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRR-MALLDVLLKSTID 299
            ||...||       .:|:::|.||::.||          |.:..|...||: ...||::|.:..:
Human   249 KLSRVLN-------QYTDTIIQERKKSLQ----------AGVKQDNTPKRKYQDFLDIVLSAKDE 296

  Fly   300 -GAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMK 363
             |:..|:.|:..||.||:..||||..:||::..|.||.:||.|.|..:|||.::||..|  :|..
Human   297 SGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS--ITWD 359

  Fly   364 LLGELKYLECVIKESLRLFPSVPIIGRYISQD-TVLDGKLIPADSNVIILIYHAQRDPDYFPDPE 427
            .|||:.|....|||:.||.|:||.|.|.:|:. |..||..:||...|::.|:....:|..:.:|:
Human   360 QLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPK 424

  Fly   428 KFIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVL- 491
            .|.|.|||.|...:..|:||.|||||.||||||:|||:|:|.||:.::.||.:.|  :..:|:.
Human   425 VFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP--DPTRPLTF 487

  Fly   492 --NVILRSTTGINCGLK 506
              :.||:...|:...||
Human   488 PNHFILKPKNGMYLHLK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	137/402 (34%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	137/403 (34%)
		heme binding region	447..460		10/12 (83%)