DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	407	Identity:	139/407 - (34%)
Similarity:	215/407 - (52%)	Gaps:	38/407 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LGDGLLISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMV---QKLYDRADGKTVINMFPV 176
            ||.||....|.|||:.|:::||.|||.||:.::||.......|:   :|:....|  |.:.::..
Human   121 LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQD--TSVEVYEH 183

  Fly   177 ACLCAMDIIAETAMGVKINAQLQPQF-TYVQSVTTASAMLAERFMNPLQRLDFTMKLF-----YP 235
            ....::|||.:.|...:.|.|..... .|.:::...|.::..|..:.|...|...||.     :.
Human   184 INSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQ 248

  Fly   236 KLLDKLNDAVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRR-MALLDVLLKSTID 299
            ||...||       .:|:::|.||::.||          |.:..|...||: ...||::|.:..:
Human   249 KLSRVLN-------QYTDTIIQERKKSLQ----------AGVKQDNTPKRKYQDFLDIVLSAKDE 296

  Fly   300 -GAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMK 363
             |:..|:.|:..||.||:..||||..:||::..|.||.:||.|.|..:|||.::||..|  :|..
Human   297 SGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS--ITWD 359

  Fly   364 LLGELKYLECVIKESLRLFPSVPIIGRYISQD-TVLDGKLIPADSNVIILIYHAQRDPDYFPDPE 427
            .|||:.|....|||:.||.|:||.|.|.:|:. |..||..:||...|::.|:....:|..:.:|:
Human   360 QLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPK 424

  Fly   428 KFIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQPVL- 491
            .|.|.|||.|...:..|:||.|||||.||||||:|||:|:|.||:.::.||.:.|  :..:|:.
Human   425 VFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP--DPTRPLTF 487

  Fly   492 --NVILRSTTGINCGLK 506
              :.||:...|:...||
Human   488 PNHFILKPKNGMYLHLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	133/385 (35%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	137/402 (34%)
CYP4X1	NP_828847.1	heme binding region	447..460		10/12 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850