DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	146/518 - (28%)
Similarity:	251/518 - (48%)	Gaps:	67/518 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRLIAEFGK 72
            :||||:|...|:.....:.::.:.||.|||..||.|.   :.|..    ..::........::||
  Rat    13 VLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGT---IFNYG----DGMWKFDDDCYKKYGK 70

  Fly    73 NIKTQMLGESGFMT-ADSKMIEAIMSSQQTIQKNNLYSLLVN--------WLGDGLLISQGKKWF 128
             |.....|...|:. .|.::|:.::..:       .||:..|        ::...:.:|:.::|.
  Rat    71 -IWGFYEGPQPFLAIMDPEIIKMVLVKE-------CYSVFTNRRCFGPMGFMKKAITMSEDEEWK 127

  Fly   129 RRRKIITPAFHFKILEDFVEVFDQQSATMVQKL-YDRADGKTVINMFPVACLCAMDIIAETAMGV 192
            |.|.|::|.|....|::...:..|...|:::.| .:.|.|:. |||..:....:||:|..|:.||
  Rat   128 RLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEP-INMKDIFGAYSMDVITGTSFGV 191

  Fly   193 KINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAV---KNMHDFTNS 254
            .:::...||..:||.   |..:|..:..:|. .|...:..|...:.:.||.::   ::|:.|...
  Rat   192 NVDSLNNPQDPFVQK---AKKILKFQIFDPF-LLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKF 252

  Fly   255 VITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLL-----KSTIDGAPLSNDDIREEVDT 314
            |.|.::..|                |..||.|:..|.:::     |.......||:.::..:...
  Rat   253 VKTMKKNRL----------------DSNQKSRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAII 301

  Fly   315 FMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESL 379
            |:|.|:|.|::||:|..|.||..|.||.::..|:...:  ...||||...|.|::||:.|:.|||
  Rat   302 FIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRAL--PNKAPVTYDALMEMEYLDMVVNESL 364

  Fly   380 RLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISP 444
            ||:|....:.|...:|..::|..||..:.|.|.||...|:|:|:.:||:|.|:|||.|.||.|.|
  Rat   365 RLYPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDP 429

  Fly   445 FAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFEL-------LPLGEEVQPVLN----VILR 496
            :.|.||..|||||||.:||::.||..:..::::|.:       :||....||:..    :||:
  Rat   430 YVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQPIFQPEGPIILK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	134/479 (28%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	130/455 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910