Protein Alignment Cyp4d14 and cyp-25A1

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_497775.3
• Gene: cyp-25A1 / 183247
• WormBaseID: WBGene00007963
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 139/562 - (24%)
• Similarity: 239/562 - (42%)
• Gaps: 118/562 - (20%)

  Fly     1 MYLELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGN---------------APLLIN 50
            :.|....|.:.|...:..:.:|...|:..:.|:.||:.:..:||               |....|
 Worm     4 LILSSLVISIFTFFIYIILARRERFKLREKIGLSGPEPHWFLGNLKQTAERKEKLGYDDANRWFN 68

  Fly    51 ESPKSKSSIFDM----QFRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLL 111
            |..:.....|.:    |..::....|:||...:  ..|.....:.:.:|..:.|...     |||
 Worm    69 ELHEQYGETFGIYYGSQMNIVISNEKDIKEVFI--KNFSNFSDRSVPSIYEANQLTA-----SLL 126

  Fly   112 VNWLGDGLLISQGKKWFRRRKIITPAF---HFKILED--------FVEVFDQQSATMVQK--LYD 163
            :|....|        |...|..|.|.|   ..|.:::        |:::. ::.|:..||  :||
 Worm   127 MNSYSSG--------WKHTRSAIAPIFSTGKMKAMQETINSKVDLFLDIL-REKASSGQKWDIYD 182

  Fly   164 RADGKTVINMFPVACLCAMDIIAETAMGVKINAQL-QPQFTYVQS-------------VTTASAM 214
            ...|.|            :|:|.:.|..:..|.|. :....||.:             :..||.:
 Worm   183 DFQGLT------------LDVIGKCAFAIDSNCQRDRNDVFYVNAKKYISNIDIRHSKIIAASVL 235

  Fly   215 LAE--RFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVITERRELLQKAIADGGDADAAL 277
            |.|  .|...|.:        |..|.|.....|:.:     |.:.|||.        ||:...:
 Worm   236 LPELSTFWKALYK--------YTPLADAEIPLVEGL-----SNVYERRR--------GGEGSDS- 278

  Fly   278 LNDVGQKRRMALLDVLLKSTID-GAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQ 341
                     :.||.:||....| ..|::..::.|....|:..|::||::::.:..|||:::|.||
 Worm   279 ---------VDLLKLLLNREDDKSKPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQ 334

  Fly   342 ARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSV-PIIGRYISQDTVLDGKLIPA 405
            .::::|:.:.   .::..:|...:..:|||:||.||:||.:|.| ..|.|...:|..:.|:..|.
 Worm   335 QKLYEEIMEA---KENGGLTYDSIHNMKYLDCVYKETLRFYPPVIHFIRRLCREDITIRGQFYPK 396

  Fly   406 DSNVIILIYHAQRDPDYFPDPEKFIPDRF-SMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKS 469
            .:.|:.|.:...|:|:.:..||:|.|:|| :.|.|.  |...:.||..|||.|:|.:||.:|.|:
 Worm   397 GAIVVCLPHTVHRNPENWDSPEEFHPERFENWEEKS--SSLKWIPFGVGPRYCVGMRFAEMEFKT 459

  Fly   470 TISKMVRHFELLPL-GE-EVQPVLN-VILRSTTGINCGLKPR 508
            ||.|::..|||... || ::.|..| ||:|....:...||||
 Worm   460 TIVKLLDTFELKQFEGEADLIPDCNGVIMRPNDPVRLHLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	120/466 (26%)
cyp-25A1	NP_497775.3	CYP3A-like	73..495	CDD:410678	122/485 (25%)