DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and CYP19A1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens

Alignment Length:	517	Identity:	117/517 - (22%)
Similarity:	216/517 - (41%)	Gaps:	101/517 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILLATA---LAWDYMRKRRHNKMYAEAGIRGPKSY-----PLVGNAPLLINESPKSKSSIFDMQF 64
            :||.|.   |.|:|         ...:.|.|| .|     ||:.:...|.    ....|..:...
Human    28 VLLLTGLFLLVWNY---------EGTSSIPGP-GYCMGIGPLISHGRFLW----MGIGSACNYYN 78

  Fly    65 RLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYS------LLVNWLG---DGLL 120
            |:..||   ::..:.||...:.:.|       ||...|.|:|.||      |.:..:|   .|::
Human    79 RVYGEF---MRVWISGEETLIISKS-------SSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGII 133

  Fly   121 ISQGKK-WFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDI 184
            .:...: |...|.....|.....|...|.|..:...|.:.:|.:..:....:::..:.....:|.
Human   134 FNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT 198

  Fly   185 ---------IAETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDK 240
                     :.|:|:.|||    |..|...|::              |.:.|...|:.:  |..|
Human   199 SNTLFLRIPLDESAIVVKI----QGYFDAWQAL--------------LIKPDIFFKISW--LYKK 243

  Fly   241 LNDAVKNMHDFTNSVITERRELL--QKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPL 303
            ...:||::.|....:|.|:|..:  ::.:.:..|....|:  :.:||               ..|
Human   244 YEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELI--LAEKR---------------GDL 291

  Fly   304 SNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGEL 368
            :.:::.:.:...:....||.:.|:.|..:|:|:||.|:..:.:|::.|||:   ..:.:..:.:|
Human   292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE---RDIKIDDIQKL 353

  Fly   369 KYLECVIKESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDR 433
            |.:|..|.||:|..|.|.::.|...:|.|:||..:...:|:|:.|....| .::||.|.:|..:.
Human   354 KVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLEN 417

  Fly   434 FSMERKGEISPFAY-TPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPL-GEEVQPVLNV 493
            |:..     .|:.| .||..|||.|.|:..||:.||:.:..::|.|.:..| |:.|:.:..:
Human   418 FAKN-----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKI 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	110/482 (23%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	104/459 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154814
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950