Protein Alignment Cyp4d14 and CYP4B1

DIOPT Version :9

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 173/540 - (32%)
• Similarity: 265/540 - (49%)
• Gaps: 94/540 - (17%)

  Fly     2 YLELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINES---PKSKSSIFDMQ 63
            :|:|..:||           ||.....|.....||.::.|.|:| |.|.|:   .|..|......
Human    26 FLKLIHLLL-----------RRQTLAKAMDKFPGPPTHWLFGHA-LEIQETGSLDKVVSWAHQFP 78

  Fly    64 FRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWF 128
            :.....||:.|        ||:..........:.|:...:..::|...:.|:|.|||:.:|.||.
Human    79 YAHPLWFGQFI--------GFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWL 135

  Fly   129 RRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRA-DGKTVINMFPVAC---LCAMDII---- 185
            :.||::||.||:.:|:.:|.||.:.:..|:.|..::| :||:    |.:.|   ..|::.:
Human   136 QHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKS----FDIFCDVGHMALNTLMKCT 196

  Fly   186 ---AETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKL------FYPKLLDKL 241
               .:|.:|...::      :|..:|:..:.::.:|.::.....||...|      |.
Human   197 FGRGDTGLGHSRDS------SYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFL------- 248

  Fly   242 NDAVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKS-TIDGAPLSN 305
             .|.:..||.|:.||.||:..||         |..:...:..:|.:..||:||.: ..|...||:
Human   249 -RACQVAHDHTDQVIRERKAALQ---------DEKVRKKIQNRRHLDFLDILLGARDEDDIKLSD 303

  Fly   306 DDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGD------DKSAPVTMKL 364
            .|:|.|||||||||||||||.|::..|.:|.:||.|.|..:|||:::||      |.
Human   304 ADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD-------- 360

  Fly   365 LGELKYLECVIKESLRLFPSVPIIGRYISQD-TVLDGKLIPADSNVIILIYHAQRDPDYFPDPEK 428
            ||::.||...||||.||:|.||.:.|.:|:. |.:||:.:||.|.:.:.||...|:...:||||.
Human   361 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEV 425

  Fly   429 FIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFEL------LPLGEEV 487
            |...|||.|...:..|||:.||||||||||||:|||.|||...:..:..||.      ||:
Human   426 FDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPI---- 486

  Fly   488 QPVLNVILRSTTGINCGLKP 507
             .:..::|||..|.:..|||
Human   487 -KMPQLVLRSKNGFHLHLKP 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	159/488 (33%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	163/502 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750