DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	516	Identity:	165/516 - (31%)
Similarity:	250/516 - (48%)	Gaps:	48/516 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPKSKSSIFDMQFRL-----I 67
            ||:.|.|....:..||.....|.....||..:.|.|:|..:.......|...:..||..     :
Mouse    21 ILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGGLDKVVTWTEQFPYAHPLWL 85

  Fly    68 AEF--GKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWFRR 130
            .:|  ..||......::.:...|.|..             .:|...:.|:|.|||:.:|.|||:.
Mouse    86 GQFIVFLNIYEPDYAKAVYSRGDPKAA-------------YVYDFFLQWIGKGLLVLEGPKWFQH 137

  Fly   131 RKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVKIN 195
            ||::||.||:.:|:.:|.:|.:.:..|:.|...:|......::|......|:|.:.:...|...:
Mouse   138 RKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDS 202

  Fly   196 AQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKL------FYPKLLDKLNDAVKNMHDFTNS 254
            .......:|..:|:..:.::.:|..:.....||...|      |.        .|.:..||.|:.
Mouse   203 GLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFL--------RACQIAHDHTDH 259

  Fly   255 VITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTID-GAPLSNDDIREEVDTFMFE 318
            ||.:|:..||         |......:.::|.:..||:||.:..: |..||:.|:|.||||||||
Mouse   260 VIRQRKAALQ---------DEKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFE 315

  Fly   319 GHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFP 383
            |||||||.|::..|.:|.:|..|.|..:|||:::||..|  .....|.::.||...:||..||:|
Mouse   316 GHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDS--FQWDDLAQMTYLTMCMKECFRLYP 378

  Fly   384 SVPIIGRYISQD-TVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISPFAY 447
            .||.:.|.:|:. |.:||:.:||.|.:.:.||...|:...:||||.|.|.|||.|......|||:
Mouse   379 PVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAF 443

  Fly   448 TPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEEVQ-PVLNVILRSTTGINCGLKP 507
            .||||||||||||:|||.|||...:..:..||..|...::. .|..:||||..||:..|||
Mouse   444 MPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILRSKNGIHLYLKP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	148/470 (31%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	155/484 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750