DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_034140.1	Gene:	Cyp46a1 / 13116	MGIID:	1341877	Length:	500	Species:	Mus musculus

Alignment Length:	523	Identity:	144/523 - (27%)
Similarity:	257/523 - (49%)	Gaps:	65/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AILLATALAWDYMRKRRHNKMYAEAGIRGP--KSYPLVGNAPLLINESPKSKSSIFDMQFRLIAE 69
            |:|||..|...::.:.|....:    |.||  .|: |:|:.|....:.......:.|:......:
Mouse    11 AVLLAFGLCCTFVHRARSRYEH----IPGPPRPSF-LLGHLPYFWKKDEDCGRVLQDVFLDWAKK 70

  Fly    70 FGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGL----LISQGK--KWF 128
            :|..::..:..::..:....:.::..:.|.:..:.:.:|..|....|:.|    |:|:..  :|:
Mouse    71 YGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECDYGRWY 135

  Fly   129 RRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVK 193
            ::||::..||....|...:|.|::::..:|:.|..:|||:|.::|..:.....:||:|:.|.|::
Mouse   136 KQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAKAAFGME 200

  Fly   194 INAQLQPQFTYVQSV------TTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFT 252
            .:..|..|....|:|      .:||.....:|| |.:|          |.|.::.::::.:....
Mouse   201 TSMLLGAQKPLSQAVKVMLEGISASRNTLAKFM-PGKR----------KQLREIRESIRLLRQVG 254

  Fly   253 NSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDD--IREEVDTF 315
            ...:..|||.|::    |.|..|.:|..:            ||:. :||   .||  :.:...||
Mouse   255 KDWVQRRREALKR----GEDMPADILTQI------------LKAE-EGA---QDDEVLLDNFVTF 299

  Fly   316 MFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLR 380
            ...||:|:.:.:|||...|:|.||:.||:..||.:|:|..:.  :..:.||.|:||..|:|||||
Mouse   300 FIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRH--LDYEDLGRLQYLSQVLKESLR 362

  Fly   381 LFPSVPIIG--RYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEIS 443
            |:|  |..|  |.:.::|::||..:|.::.::...|...|...||.||..|.||||.   .|...
Mouse   363 LYP--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG---PGAPK 422

  Fly   444 P-FAYTPFSAGPRNCIGQKFAMLEMKSTISKMVR--HFELLPLGEEVQPVLNVILRSTTGINCGL 505
            | |.|.|||.|.|:||||:||.:|:|..::|:::  .|.|:| |:.........|:....:.|.|
Mouse   423 PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVP-GQRFGLQEQATLKPLDPVLCTL 486

  Fly   506 KPR 508
            :||
Mouse   487 RPR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	132/475 (28%)
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	131/471 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4382
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860