Protein Alignment Cyp4d14 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 159/483 - (32%)
• Similarity: 255/483 - (52%)
• Gaps: 30/483 - (6%)

  Fly    36 PKSYPLVGNAPL-LINES--PKSKSSIFDMQFRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMS 97
            |:...|:|:..: |.||:  ...|..:.:|...|:...|..:...:|....:       |:.::.
Human    63 PRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDY-------IKPLLG 120

  Fly    98 SQQTI-QKNNL-YSLLVNWLGDGLLISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQK 160
            :...| .|::| |..|..|||||||:|:|.||.|.|:::||||||.||:.::::|:|.:..|..|
Human   121 ASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAK 185

  Fly   161 LYDRADGKTV-INMFPVACLCAMDIIAETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQ 224
            ....|:|..| ::||....|..:|.:.:.......|.| :....|:.::...||:...|......
Human   186 WRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQ-EKMSDYISAIIELSALSVRRQYRLHH 249

  Fly   225 RLDFTMKLFYPKLLD--KLNDAVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRM 287
            .|||    .|.:..|  :...|...:|.||..||.|||..|::.     .|:|.|  ...|.:.:
Human   250 YLDF----IYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQ-----GAEAWL--KAKQGKTL 303

  Fly   288 ALLDVLLKS-TIDGAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDV 351
            ..:||||.: ..||..||::|||.|.|||||||||||:|.|::..:.||::||.|.:..:|:::|
Human   304 DFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEV 368

  Fly   352 IGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVPIIGRYISQDTVL-DGKLIPADSNVIILIYH 415
            :...:...:....|.:|.:....||||||.:|.|.::.|..::|..| ||::||.....::.||.
Human   369 MKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYG 433

  Fly   416 AQRDPDYFPDPEKFIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFEL 480
            ...:|..:||.:.:.|.||..:...:.||.||.||||||||||||.|||.|::..::..:..|.|
Human   434 THHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL 498

  Fly   481 -LPLGEEVQPVLNVILRSTTGINCGLKP 507
             :....:|:....:|||:..|:...::|
Human   499 SVDRTRKVRRKPELILRTENGLWLKVEP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	149/439 (34%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	152/459 (33%)