Protein Alignment Cyp4d14 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_001259179.1
• Gene: Cyp4d14 / 45706
• FlyBaseID: FBgn0023541
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 144/521 - (27%)
• Similarity: 258/521 - (49%)
• Gaps: 61/521 - (11%)

  Fly     7 AILLATALAWDYMRKRRHNKMYAEAGIRGP--KSYPLVGNAPLLINESPKSKSSIFDMQFRLIAE 69
            |:|||..|...::.:.|....:    |.||  .|: |:|:.|....:.......:.|:......:
Human    11 AVLLAFGLCCTFVHRARSRYEH----IPGPPRPSF-LLGHLPCFWKKDEVGGRVLQDVFLDWAKK 70

  Fly    70 FGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGL----LISQ--GKKWF 128
            :|..::..:..::..:....:.::..:.|.:..:.:.:|..|....|:.|    |:|:  .::|.
Human    71 YGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWH 135

  Fly   129 RRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIAETAMGVK 193
            ::|::|..||....|...:|.|::::..:|:.|..:|||:|.::|..:....||||:|:.|.|::
Human   136 KQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGME 200

  Fly   194 INAQLQPQFTYVQSV------TTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFT 252
            .:..|..|....|:|      .|||.....:|: |.:|          |.|.::.::::.:....
Human   201 TSMLLGAQKPLSQAVKLMLEGITASRNTLAKFL-PGKR----------KQLREVRESIRFLRQVG 254

  Fly   253 NSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIREEVDTFMF 317
            ...:..|||.|::    |.:..|.:|..:            ||:. :||. .::.:.:...||..
Human   255 RDWVQRRREALKR----GEEVPADILTQI------------LKAE-EGAQ-DDEGLLDNFVTFFI 301

  Fly   318 EGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLF 382
            .||:|:.:.:|||...|:|.||:.||:..||.:|||..:.  :..:.||.|:||..|:||||||:
Human   302 AGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY--LDFEDLGRLQYLSQVLKESLRLY 364

  Fly   383 PSVPIIG--RYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISP- 444
            |  |..|  |.:.::|::||..:|.::.::...|...|...||.||..|.||||.   .|...|
Human   365 P--PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFG---PGAPKPR 424

  Fly   445 FAYTPFSAGPRNCIGQKFAMLEMKSTISKMVR--HFELLPLGEEVQPVLNVILRSTTGINCGLKP 507
            |.|.|||.|.|:||||:||.:|:|..::|:::  .|.|:| |:.........|:....:.|.|:|
Human   425 FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP-GQRFGLQEQATLKPLDPVLCTLRP 488

  Fly   508 R 508
            |
Human   489 R 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	CYP4	71..503	CDD:410721	126/448 (28%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	127/459 (28%)