DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d14 and Cyp2c69

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001097995.1	Gene:	Cyp2c69 / 100043108	MGIID:	3721049	Length:	491	Species:	Mus musculus

Alignment Length:	534	Identity:	110/534 - (20%)
Similarity:	201/534 - (37%)	Gaps:	141/534 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLL--------INESPKSKSSIFDM 62
            |.:||:   .|.....||:..       .||...|::||..|:        :....|:...:|.:
Mouse    13 FMLLLS---LWRQRSARRNLP-------PGPTPLPIIGNYHLIDMKDIGQCLTNFSKTYGPVFTL 67

  Fly    63 QF---RLIAEFG-KNIKTQML-------GESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLG 116
            .|   .::...| :.||..::       |...|...|.            :.|           |
Mouse    68 YFGSQPIVVLHGYEAIKEALIDHGEVFSGRGSFPFFDK------------VSK-----------G 109

  Fly   117 DGLLISQGKKWFRRRKIITP------AFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFP 175
            .|:..|.|..| :..::.|.      |...:.:|:.|    |:.|..:.|...:.:|......|.
Mouse   110 KGIGFSHGNVW-KATRVFTVNTLRNLAMGKRTIENKV----QEEAQWLMKELKKTNGSPCDPQFI 169

  Fly   176 VACLCAMDIIAETAMGVKINAQLQPQFTYVQSVTTASAMLAE---RFMNPLQRL-DFT----MKL 232
            :.| ...::|.......:.:.:.:...:.:..|...:.:|:.   :..|.:..| |:.    .|.
Mouse   170 IGC-APCNVICSIVFQNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPILIDYCPGRHNKF 233

  Fly   233 F--------YPKLLDKLND-----AVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQK 284
            |        |  ||:|:.:     .|.|..||.:..:.:||:                  |.|
Mouse   234 FKNHTWIKSY--LLEKIKEHEESLDVTNPRDFIDYFLIQRRQ------------------DKG-- 276

  Fly   285 RRMALLDVLLKSTIDGAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVR 349
                         |:....:.:.:...|...:|.|.:|.:|::.|...||.:|..:.|:|.:|:.
Mouse   277 -------------IEHMEYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEID 328

  Fly   350 DVIG--------DDKSAPVTMKLLGEL-KYLECVIKESLRLFPSVPIIGRYISQDTVLDGKLIPA 405
            :|||        |.|..|.|..::.|: :|::        |.|:..:  ..::.||......||.
Mouse   329 NVIGRHRSPCMQDRKHMPYTNAMVHEVQRYVD--------LGPTSLV--HEVTCDTKFRNYFIPK 383

  Fly   406 DSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISPFAY-TPFSAGPRNCIGQKFAMLEMKS 469
            .:.|:..:.....|...||:||.|.|..| ::..|......| .|||||.|.|:|:..|.:|:..
Mouse   384 GTQVMTSLSSVLHDSTEFPNPEVFDPGHF-LDDNGNFKKSDYFVPFSAGKRICVGESLARMELFL 447

  Fly   470 TISKMVRHFELLPL 483
            .::.::::|:|.||
Mouse   448 FLTTILQNFKLKPL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	104/506 (21%)
Cyp2c69	NP_001097995.1	p450	30..487	CDD:278495	104/514 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010