DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d14 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	436	Identity:	155/436 - (35%)
Similarity:	243/436 - (55%)	Gaps:	29/436 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 GESGFMTA-DSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQGKKWFRRRKIITPAFHFKIL 143
            |.:.::|. |...::.|:..... :.|.:|.||..|:|.|||:..|:.||:.|:::|||||:.||
Mouse    91 GSNAYLTVYDPDYMKVILGRSDP-KANGIYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDIL 154

  Fly   144 EDFVEVFDQQSATMVQKLYDRADGK-TVINMFPVACLCAMDIIAETAMGVKINAQLQPQF-TYVQ 206
            :.:|:........|:.| ::|..|: :.|.:|....|..:|.:.:.|...|.:.|:...: ||:|
Mouse   155 KPYVKNMADSIRLMLDK-WERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYKTYLQ 218

  Fly   207 SVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDFTNSVITERRELLQKAIADGG 271
            ::...:.:...|..|...:.|...:|.....|.|  .|.:..||.|:.||..|::.||    |.|
Mouse   219 AIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAK--QACQLAHDHTDGVIKMRKDQLQ----DEG 277

  Fly   272 DADAALLNDVGQKRRMALLDVLLKSTID-GAPLSNDDIREEVDTFMFEGHDTTTSSIAFTCYLLA 335
            :     |.::.:|||:..||:||.:.:: |..:|:.|:|.|||||||||||||.|.:::..|.||
Mouse   278 E-----LENIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALA 337

  Fly   336 RHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESLRLFPSVPIIGRYISQD-TVLD 399
            .|||.|.|..:||:.::||..|  :|...|.::.|....|||:|||:|.||.|.|.:|.. |..|
Mouse   338 THPEHQQRCREEVQSLLGDGSS--ITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPD 400

  Fly   400 GKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEISP---FAYTPFSAGPRNCIGQK 461
            |:.:|....|.:.||....:|..:|:||.|.|.||:.:     ||   .::.|||.|.|||||::
Mouse   401 GRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPD-----SPRHSHSFLPFSGGARNCIGKQ 460

  Fly   462 FAMLEMKSTISKMVRHFELLPLGEEV-QPVLNVILRSTTGINCGLK 506
            |||.|:|..::..:.||||||....| :|:..::|:|..||...||
Mouse   461 FAMSELKVIVALTLLHFELLPDPTRVPEPLARIVLKSKNGIYLHLK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	148/417 (35%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	153/431 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750