DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha68-1 and vma1

DIOPT Version :9

Sequence 1:	NP_001260426.1	Gene:	Vha68-1 / 45668	FlyBaseID:	FBgn0265262	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_593425.1	Gene:	vma1 / 2541660	PomBaseID:	SPAC343.05	Length:	619	Species:	Schizosaccharomyces pombe

Alignment Length:	614	Identity:	396/614 - (64%)
Similarity:	501/614 - (81%)	Gaps:	9/614 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRKFKD-EERESEYGRVYAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYEE 67
            :|..|: :|.|:.||.:::||||||.|..|.|.:||||||||:.|||||:||:..|..|||||||
pombe    12 IRSLKNYDEHENRYGSIFSVSGPVVVAANMLGCSMYELVRVGHEELVGEVIRIHQDKCTIQVYEE 76

  Fly    68 TSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLRDIGVMTNSIYIPKGVNTTALSRSEMWE 132
            |||:||||||.|||||||||||||:..:|:|||||||:.|...:.|||||:|:||.:|:|...|:
pombe    77 TSGLTVGDPVQRTGKPLSVELGPGLAETIYDGIQRPLKQIFDKSQSIYIPRGINTESLNREHKWD 141

  Fly   133 FNP-LNVRVGSHITGGDLYGVVHENTLVK-QRMIVAPRAKGTVRYIAPAGNYNLEDIVLETEFDG 195
            |.| .::|:|.|::|||::|.|.||:|.. .::::.|||:|||.|||.||:|::::.:||.||:|
pombe   142 FTPNKDLRIGDHVSGGDVFGSVFENSLFNDHKIMLPPRARGTVTYIAEAGSYHVDEKLLEVEFNG 206

  Fly   196 EITKHTMLQVWPVRQPRPVTEKLPANHPLFTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAL 260
            :....:||..||||..|||.:.|.||.||.|||||||:|:|||||||||||||||||||||||:|
pombe   207 KKHSFSMLHTWPVRAARPVADNLTANQPLLTGQRVLDALYPCVQGGTTAIPGAFGCGKTVISQSL 271

  Fly   261 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELTCEIDGVTESIMKRTALVANTSNMPVAAREASIY 325
            |||||||:|:|||||||||||:|||.||||||.:|:|..|.|||||.||||||||||||||||||
pombe   272 SKYSNSDLIVYVGCGERGNEMAEVLMDFPELTIDINGKPEPIMKRTTLVANTSNMPVAAREASIY 336

  Fly   326 TGITLSEYFRDMGYNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLATFYERAGRVK 390
            |||||:||:||.|.||:|||||||||||||||||||||||||||||||||||:||:|||||||.:
pombe   337 TGITLAEYYRDQGKNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGAKLASFYERAGRAR 401

  Fly   391 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYM 455
            |||:|:|||:||||||||||||||||||||||||||||||||||||||||||||||..:|||||:
pombe   402 CLGSPDREGTVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINTSLSYSKYI 466

  Fly   456 RALDEYYDKNYPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKVTLEVAKLLKDDFLQQN 520
            .||..:|::..|.|..||.::|:|:|:|:.:.||:|||||::|:|||||||::|.::|:||||||
pombe   467 NALQPWYEERVPGFNTLRDQIKQIIQQEDSMLEIIQLVGKSALSETDKVTLDIAGIIKNDFLQQN 531

  Fly   521 SYSPYDRVCPFYKTVGMLRNIMAFYETARHAVESTAQSDNKITWNTIRESMGGIMYQLSSMKFKD 585
            .||.|||.||.|||..|:||::|:|..|:.|||:     ..:.|:.|:||...|.|:|:||||::
pombe   532 GYSDYDRCCPLYKTYHMMRNMIAYYTKAKSAVET-----GSVPWSKIKESTSDIFYELTSMKFEN 591

  Fly   586 PVKDGEQKIKADYDQLYEDLQQAFRNLED 614
            | .:||::|...|:.|::.::..|..|.:
pombe   592 P-NEGEKEIVEHYETLHKKIEDKFHTLTE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-1	NP_001260426.1	V-ATPase_V1_A	15..606	CDD:273411	390/592 (66%)
vma1	NP_593425.1	V-ATPase_V1_A	24..611	CDD:273411	390/592 (66%)
		ATP-synt_ab_N	28..90	CDD:280947	42/61 (69%)
		V_A-ATPase_A	92..465	CDD:238554	271/372 (73%)
		ATP-synt_ab_C	483..619	CDD:278722	67/141 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	408	1.000	Domainoid score	I94
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123934
Inparanoid	1	1.050	816	1.000	Inparanoid score	I62
OMA	1	1.010	-	-		QHG60789
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		otm47164
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	O	PTHR43607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1565
TreeFam	1	0.960	-	-
	13	12.830