DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha68-1 and Atp6v1a

DIOPT Version :9

Sequence 1:	NP_001260426.1	Gene:	Vha68-1 / 45668	FlyBaseID:	FBgn0265262	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001345132.1	Gene:	Atp6v1a / 11964	MGIID:	1201780	Length:	617	Species:	Mus musculus

Alignment Length:	614	Identity:	510/614 - (83%)
Similarity:	562/614 - (91%)	Gaps:	1/614 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNLRKFKDEERESEYGRVYAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYE 66
            |.|.|.:||::||.:|.|:.||||||||..|:|:|||||||||:.||||||||||||||||||||
Mouse     4 SKLPKIRDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYE 68

  Fly    67 ETSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLRDIGVMTNSIYIPKGVNTTALSRSEMW 131
            |||||:||||||||||||||||||||||:|||||||||.||...|.|||||:|||.:||||...|
Mouse    69 ETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKW 133

  Fly   132 EFNP-LNVRVGSHITGGDLYGVVHENTLVKQRMIVAPRAKGTVRYIAPAGNYNLEDIVLETEFDG 195
            ||.| .|:||||||||||:||:|:||:|:|.::::.||.:|:|.||||.|||:..|:|||.||:|
Mouse   134 EFIPSKNLRVGSHITGGDIYGIVNENSLIKHKIMLPPRNRGSVTYIAPPGNYDASDVVLELEFEG 198

  Fly   196 EITKHTMLQVWPVRQPRPVTEKLPANHPLFTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAL 260
            ...|.:|:|||||||.|||||||||||||.|||||||:|||||||||||||||||||||||||:|
Mouse   199 VKEKFSMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSL 263

  Fly   261 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELTCEIDGVTESIMKRTALVANTSNMPVAAREASIY 325
            ||||||||||||||||||||||||||||||||.|:||..||||||||||||||||||||||||||
Mouse   264 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIY 328

  Fly   326 TGITLSEYFRDMGYNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLATFYERAGRVK 390
            ||||||||||||||:|:||||||||||||||||||||||||||||||||||||||:|||||||||
Mouse   329 TGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 393

  Fly   391 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYM 455
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Mouse   394 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYM 458

  Fly   456 RALDEYYDKNYPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKVTLEVAKLLKDDFLQQN 520
            |||||||||::.||||||||.||||||||||:||||||||||||||||:|||||||:||||||||
Mouse   459 RALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQN 523

  Fly   521 SYSPYDRVCPFYKTVGMLRNIMAFYETARHAVESTAQSDNKITWNTIRESMGGIMYQLSSMKFKD 585
            .|:||||.||||||||||.|:::||:.||.|||:||||||||||:.|||.||.|:|:||||||||
Mouse   524 GYTPYDRFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKITWSIIREHMGEILYKLSSMKFKD 588

  Fly   586 PVKDGEQKIKADYDQLYEDLQQAFRNLED 614
            ||||||.||||||.||.||:|.|||:|||
Mouse   589 PVKDGEAKIKADYAQLLEDMQNAFRSLED 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-1	NP_001260426.1	V-ATPase_V1_A	15..606	CDD:273411	496/591 (84%)
Atp6v1a	NP_001345132.1	V-ATPase_V1_A	17..609	CDD:273411	496/591 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837777
Domainoid	1	1.000	441	1.000	Domainoid score	I542
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123934
Inparanoid	1	1.050	1034	1.000	Inparanoid score	I271
Isobase	1	0.950	-	0	Normalized mean entropy	S546
OMA	1	1.010	-	-		QHG60789
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		otm42968
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	O	PTHR43607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1565
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.710