Protein Alignment dom and CHD1

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_011091.1
• Gene: CHD1 / 856911
• SGDID: S000000966
• Length: 1468
• Species: Saccharomyces cerevisiae
• Alignment Length: 1986
• Identity: 386/1986 - (19%)
• Similarity: 665/1986 - (33%)
• Gaps: 800/1986 - (40%)

  Fly   669 MNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDF 733
            ::..|...|.|...|.:........::..:|..||||:.|.::.      ::.:|.: ::.|.:|
Yeast     6 ISTEVLQNPELYGLRRSHRAAAHQQNYFNDSDDEDDEDNIKQSR------RKRMTTI-EDDEDEF 63

  Fly   734 DDFLNDLPPGYLENRDKLMKEEQ--SSAIK--TETPDDSDDSEFEAKEASDDDENTISK------ 788
            :|...:...|..|:.:...:::.  .|.||  ...|.....|:.::|..|..::.:..|
Yeast    64 EDEEGEEDSGEDEDEEDFEEDDDYYGSPIKQNRSKPKSRTKSKSKSKPKSQSEKQSTVKIPTRFS 128

  Fly   789 ---QEEAEQEIDHKKEIDELEADNDLSVEQLLAK---YKSEQPPSPK-----------RRKLAPR 836
               .:.....||:..: |.||:::|...|:.|::   :::...|.|:           |.|.:..
Yeast   129 NRQNKTVNYNIDYSDD-DLLESEDDYGSEEALSEENVHEASANPQPEDFHGIDIVINHRLKTSLE 192

  Fly   837 D--------PELDS-----------DDDSTAVDSTEESEDAA----------------TEDE--- 863
            :        |:|::           .|:|...::.|..|...                .||:
Yeast   193 EGKVLEKTVPDLNNCKENYEFLIKWTDESHLHNTWETYESIGQVRGLKRLDNYCKQFIIEDQQVR 257

  Fly   864 -------EDLSTVKTDTDMEEQ---DE-QEDGLKSLMADADATSGAAGSGS------------TA 905
                   ||:..:    |||.:   || :|..:...:.|:...|...|:..            ..
Yeast   258 LDPYVTAEDIEIM----DMERERRLDEFEEFHVPERIIDSQRASLEDGTSQLQYLVKWRRLNYDE 318

  Fly   906 GASGNKDDMLNDAAALAESLQPKGNT----LSSTNV-----------VTPVPFLLKHSLREYQHI 955
            ....|..|::..|....:..|.:.|:    ..|:|.           |.| ||:....||::|..
Yeast   319 ATWENATDIVKLAPEQVKHFQNRENSKILPQYSSNYTSQRPRFEKLSVQP-PFIKGGELRDFQLT 382

  Fly   956 GLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKW 1020
            |::|:..:..:..|||||||||||||:||:|.::.|..|:...|||:||||.|.|..|...|:||
Yeast   383 GINWMAFLWSKGDNGILADEMGLGKTVQTVAFISWLIFARRQNGPHIIVVPLSTMPAWLDTFEKW 447

  Fly  1021 CPGFKILTYYGSQKERKLKR--VGWTKPNA-------FHVCITSYKLVVQDQQSFRRKKWKYLIL 1076
            .|....:.|.|:||.|...|  ..:|.|.|       |:|.:|:|:.:::|:......||:::.:
Yeast   448 APDLNCICYMGNQKSRDTIREYEFYTNPRAKGKKTMKFNVLLTTYEYILKDRAELGSIKWQFMAV 512

  Fly  1077 DEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNP 1141
            |||..:||.:|..::.|.:|....|:|:|||||||::.||.:|::||||..|:..:|..
Yeast   513 DEAHRLKNAESSLYESLNSFKVANRMLITGTPLQNNIKELAALVNFLMPGRFTIDQEID------ 571

  Fly  1142 MTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSR 1206
                .|...|..|..|..||:.|:||:||||||:|||.:|.|.|.::...||:.|...|::.:::
Yeast   572 ----FENQDEEQEEYIHDLHRRIQPFILRRLKKDVEKSLPSKTERILRVELSDVQTEYYKNILTK 632

  Fly  1207 AKTRETL-QTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFT 1270
            ..:..|. ..|...|::|::.:|:|..|||.:|:
Yeast   633 NYSALTAGAKGGHFSLLNIMNELKKASNHPYLFD------------------------------- 666

  Fly  1271 QINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAEL 1335
                                                                             
Yeast   667 ----------------------------------------------------------------- 666

  Fly  1336 AQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSS 1400
                  ||.:                        |||::..
Yeast   667 ------NAEE------------------------RVLQKFG------------------------ 677

  Fly  1401 STTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSK 1465
                                                   |||
Yeast   678 ---------------------------------------DGK----------------------- 680

  Fly  1466 TTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKV 1530
                                                                             
Yeast   681 ----------------------------------------------------------------- 680

  Fly  1531 QELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCT 1595
                 |.:|..|..|
Yeast   681 -----MTRENVLRGL-------------------------------------------------- 690

  Fly  1596 AMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIV 1660
                                                                             
Yeast   691 ----------------------------------------------------------------- 690

  Fly  1661 DQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVL 1725
                         |:|.               ||:..:|:||.:||.:|||||||:||.:|||:|
Yeast   691 -------------IMSS---------------GKMVLLDQLLTRLKKDGHRVLIFSQMVRMLDIL 727

  Fly  1726 EAFLNYHGHIYLRLDGSTRVEQRQILMERFNG-DKRIFCFILSTRSGGVGINLTGADTVIFYDSD 1789
            ..:|:..|..:.||||:....||:|.::.||. |...|.|:||||:||:||||..||||:.:|||
Yeast   728 GDYLSIKGINFQRLDGTVPSAQRRISIDHFNSPDSNDFVFLLSTRAGGLGINLMTADTVVIFDSD 792

  Fly  1790 WNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLS----DMAIEGGNFTTTY 1850
            |||..|.||..|.|||||...|.:|||||:.|:|..:|::|.:|.:|.    .:.:..||   .|
Yeast   793 WNPQADLQAMARAHRIGQKNHVMVYRLVSKDTVEEEVLERARKKMILEYAIISLGVTDGN---KY 854

  Fly  1851 FK---------SSTIK----DLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSL 1902
            .|         |:.:|    ::||.      ..:|:|.|:.:
Yeast   855 TKKNEPNAGELSAILKFGAGNMFTA------TDNQKKLEDLN----------------------- 890

  Fly  1903 RAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATEDPNAEGG----PQVELS--KADL 1961
              .:..|..|||.           ....||.|            :..||    .|.|::  |||:
Yeast   891 --LDDVLNHAEDH-----------VTTPDLGE------------SHLGGEEFLKQFEVTDYKADI 930

  Fly  1962 EMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQK-REWEANRLAAMHKEEELLKQ- 2024
            :..:::.:                     |:|:..:.|.:.:| .|:...:|..|::.:..||:
Yeast   931 DWDDIIPE---------------------EELKKLQDEEQKRKDEEYVKEQLEMMNRRDNALKKI 974

  Fly  2025 ETEAEEMLTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYSLSFMYEL-------- 2081
            :.......|.:..||.:.. .||::..:         .:.||.|...:..:..:|:.
Yeast   975 KNSVNGDGTAANSDSDDDS-TSRSSRRR---------ARANDMDSIGESEVRALYKAILKFGNLK 1029

  Fly  2082 ----EPIAETDLPPVYVRK-----------------EHKRSRTD---------AGYDGSRRPNKM 2116
                |.||:..||.....|                 |.:::|.:         ..|....:..::
Yeast  1030 EILDELIADGTLPVKSFEKYGETYDEMMEAAKDCVHEEEKNRKEILEKLEKHATAYRAKLKSGEI 1094

  Fly  2117 RREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCV 2181
            :.|:.   |:   |.|..:|:..:||.|:..|  :||            ..|.|.....::.
Yeast  1095 KAENQ---PK---DNPLTRLSLKKREKKAVLF--NFK------------GVKSLNAESLLSR--- 1136

  Fly  2182 FEDMAILHVLVNL----QGLPCSLMLLSPGQTPNWD----------------------------- 2213
            .||:..|..|:|.    ..|..||...:|....||.
Yeast  1137 VEDLKYLKNLINSNYKDDPLKFSLGNNTPKPVQNWSSNWTKEEDEKLLIGVFKYGYGSWTQIRDD 1201

  Fly  2214 ---------LVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTL----RTE 2265
                     .::|:.|..:|...|:.      :|...|.::||.:..  ..||:...:    |.:
Yeast  1202 PFLGITDKIFLNEVHNPVAKKSASSS------DTTPTPSKKGKGITG--SSKKVPGAIHLGRRVD 1258

  Fly  2266 YLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSAPSLMNP-KHMEVLQ 2329
            ||.|.||....|:...:|..:....|..|:....|.|...|:..|:...|.|:...| |.|:.|.
Yeast  1259 YLLSFLRGGLNTKSPSADIGSKKLPTGPSKKRQRKPANHSKSMTPEITSSEPANGPPSKRMKALP 1323

  Fly  2330 E--FGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQ 2392
            :  ..::| :..:||.:......:|:......:|.|.|..|....::.....::..:.....:
Yeast  1324 KGPAALIN-NTRLSPNSPTPPLKSKVSRDNGTRQSSNPSSGSAHEKEYDSMDEEDCRHTMSAI-- 1385

  Fly  2393 QQQPQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSN 2428
                :..::::::..:...:::..::::.:|.|:.|
Yeast  1386 ----RTSLKRLRRGGKSLDRKEWAKILKTELTTIGN 1417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727
		HepA	692..>1235	CDD:440319	173/655 (26%)
		DEXQc_SRCAP	949..1171	CDD:350761	89/230 (39%)
		SF2_C_SNF	1685..1817	CDD:350180	66/132 (50%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	89/251 (35%)
		HEC1	<1858..>2031	CDD:444066	28/180 (16%)
		SP1-4_N	2486..>2819	CDD:425404
CHD1	NP_011091.1	CD1_tandem_CHD1_yeast_like	175..247	CDD:349312	8/71 (11%)
		CD2_tandem_ScCHD1_like	283..341	CDD:349311	8/57 (14%)
		PLN03142	363..>961	CDD:215601	237/1111 (21%)
		Cdh1_DBD_1	1010..1129	CDD:408024	22/138 (16%)
		SANT_TRF	1175..>1204	CDD:212558	0/28 (0%)
		DUF4208	1368..1460	CDD:464035	3/56 (5%)