Protein Alignment dom and ISW2

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_014948.1
• Gene: ISW2 / 854480
• SGDID: S000005831
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 1772
• Identity: 354/1772 - (19%)
• Similarity: 569/1772 - (32%)
• Gaps: 759/1772 - (42%)

  Fly   753 KEEQSSAI---KTETPD----DSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADND 810
            :|||.|..   |:|:|.    |:.||:   ...|.||:|....:|.:::||
Yeast     5 QEEQRSDTKNSKSESPSEVLVDTLDSK---SNGSSDDDNIGQSEELSDKEI-------------- 52

  Fly   811 LSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDM 875
            .:||....:|.:::    |::.:...||:.....|.:......:.....|:.......:|...|.
Yeast    53 YTVEDRPPEYWAQR----KKKFVLDVDPKYAKQKDKSDTYKRFKYLLGVTDLFRHFIGIKAKHDK 113

  Fly   876 EEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTP 940
            ..|..    ||.|.:||:..|.:..:.|::.....|.:...||..:|:..:...:|......|:.
Yeast   114 NIQKL----LKQLDSDANKLSKSHSTVSSSSRHHRKTEKEEDAELMADEEEEIVDTYQEDIFVSE 174

  Fly   941 VP-FLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIV 1004
            .| |:....||:||..||:||::::|.||:||||||||||||:|||:.|.:|...|...||.||:
Yeast   175 SPSFVKSGKLRDYQVQGLNWLISLHENKLSGILADEMGLGKTLQTISFLGYLRYVKQIEGPFLII 239

  Fly  1005 VPSSVMLNWEMEFKKWCPGFKILTYYGSQKERK--LKRVGWTKPNAFHVCITSYKLVVQDQQSFR 1067
            ||.|.:.||..||.||.|...:|..:|.:..|.  ::.:  .....|.|.||||::|::::.:.:
Yeast   240 VPKSTLDNWRREFLKWTPNVNVLVLHGDKDTRADIVRNI--ILEARFDVLITSYEMVIREKNALK 302

  Fly  1068 RKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHR 1132
            |..|:|:::|||..|||.:|...|::..|.::.|||:|||||||:|.|||:|::||:|.:|....
Yeast   303 RLAWQYIVIDEAHRIKNEQSALSQIIRLFYSKNRLLITGTPLQNNLHELWALLNFLLPDIFGDSE 367

  Fly  1133 EFKEWFSNPMTGMIEGNMEYN-ETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQ 1196
            .|.|||.       :.|.|.: |.:|.:||.|:.||||||:|.:|||.:..|.|..:...:::.|
Yeast   368 LFDEWFE-------QNNSEQDQEIVIQQLHSVLNPFLLRRVKADVEKSLLPKIETNVYVGMTDMQ 425

  Fly  1197 RYLYEDFMSR-------------AKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQ 1248
            ...|:..:.:             .|||          ::|::|||||.||||.:||
Yeast   426 IQWYKSLLEKDIDAVNGAVGKREGKTR----------LLNIVMQLRKCCNHPYLFE--------- 471

  Fly  1249 MDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAP 1313
                                                                             
Yeast   472 ----------------------------------------------------------------- 471

  Fly  1314 LPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSAS 1378
                                             ||.|.
Yeast   472 ---------------------------------GAEPG--------------------------- 476

  Fly  1379 INPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKP 1443
                                                                             
Yeast   477 ----------------------------------------------------------------- 476

  Fly  1444 FFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQK 1508
                                                                             
Yeast   477 ----------------------------------------------------------------- 476

  Fly  1509 QSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRC 1573
                             .||...|
Yeast   477 -----------------PPYTTDE----------------------------------------- 483

  Fly  1574 MQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRI 1638
                                             ||:
Yeast   484 ---------------------------------HLI----------------------------- 486

  Fly  1639 RRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLR 1703
                                                               ::.||:..:|:||:
Yeast   487 ---------------------------------------------------FNSGKMIILDKLLK 500

  Fly  1704 QLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFN-GDKRIFCFILS 1767
            :||..|.|||||:||:::||:||.:..:....|.|:||||..|:|...::.:| .:...|.|:|:
Yeast   501 RLKEKGSRVLIFSQMSRLLDILEDYCYFRDFEYCRIDGSTSHEERIEAIDEYNKPNSEKFVFLLT 565

  Fly  1768 TRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQ 1832
            ||:||:||||..|||||.:||||||..|.||.||.|||||.:.||:||.|:|..||..::::|.|
Yeast   566 TRAGGLGINLVTADTVILFDSDWNPQADLQAMDRAHRIGQKKQVHVYRFVTENAIEEKVIERAAQ 630

  Fly  1833 KRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVET 1897
            |..|..:.|:.|....|....::..||..|.|.......::|:
Yeast   631 KLRLDQLVIQQGTGKKTASLGNSKDDLLDMIQFGAKNMFEKKA---------------------- 673

  Fly  1898 EKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVELSKADLE 1962
                                      :|..|.||:.:..:.....|::.||:   ...|...||:
Yeast   674 --------------------------SKVTVDADIDDILKKGEQKTQELNAK---YQSLGLDDLQ 709

  Fly  1963 MQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKR------EWEANRLAAMHKEEEL 2021
            ..|.::..|..|             |..:..         ||:      ||    :....:|..
Yeast   710 KFNGIENQSAYE-------------WNGKSF---------QKKSNDKVVEW----INPSRRERR- 747

  Fly  2022 LKQETEAEEMLTYSRKDSSNQV--WISRNTMEQMPMWCPPTPPQDNDNDIYIDYSLSFMY---EL 2081
                   .|..|||..|...::  ..|::..:|.|....|..|:       :.:...|.:   ||
Yeast   748 -------REQTTYSVDDYYKEIIGGGSKSASKQTPQPKAPRAPK-------VIHGQDFQFFPKEL 798

  Fly  2082 EPIAETDLPPVYVRK---------------------------EHKRSRTDAGYDG----SRRPNK 2115
            :.:.|.:  .:|.:|                           |:|.:....|:.|    .||..:
Yeast   799 DALQEKE--QLYFKKKVNYKVTSYDITGDIRNEGSDAEEEEGEYKNAANTEGHKGHEELKRRIEE 861

  Fly  2116 MRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWC 2180
            .:.:.|..|..:..|           ||:.|                 :|.:|      |...|.
Yeast   862 EQEKINSAPDFTQED-----------ELRKQ-----------------ELISK------AFTNWN 892

  Fly  2181 VFEDMAILHVLV-----NLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWR----- 2235
            ..:.||.::...     :::.:..|:    ..:||      |.|...:|.:       |.
Yeast   893 KRDFMAFINACAKYGRDDMENIKKSI----DSKTP------EEVEVYAKIF-------WERLKEI 940

  Fly  2236 --YETHIQPREEGKVVESPKKQKKLK--PTL---RTEYLKSPLRYLRTTQLYVSDNNASFYKTMR 2293
              :|.::...|.|:     ||.:|||  .||   :.|..|.||..|...  |..:|....|.|:.
Yeast   941 NGWEKYLHNVELGE-----KKNEKLKFQETLLRQKIEQCKHPLHELIIQ--YPPNNARRTYNTLE 998

  Fly  2294 SRFDSIK-TAYLKKAPPPKRQFSAPSLMN-----------------PKHMEVLQEFGILNYDQPV 2340
            .:|..:. ..|..:|.....:.....:|:                 .|.:..|....:..|:||
Yeast   999 DKFLLLAVNKYGLRADKLYEKLKQEIMMSDLFTFDWFIKTRTVHELSKRVHTLLTLIVREYEQP- 1062

  Fly  2341 SPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQQQQPQQVVQQVQQ 2405
                    .|||.:..:........|:         .|::..:....|.||        ...|..
Yeast  1063 --------DANKKKRSRTSATREDTPL---------SQNESTRASTVPNLP--------TTMVTN 1102

  Fly  2406 QQQQQQQQQQQQVVQQQ 2422
            |:.......::..:.|:
Yeast  1103 QKDTNDHVDKRTKIDQE 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727
		HepA	692..>1235	CDD:440319	163/505 (32%)
		DEXQc_SRCAP	949..1171	CDD:350761	99/224 (44%)
		SF2_C_SNF	1685..1817	CDD:350180	64/132 (48%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	80/234 (34%)
		HEC1	<1858..>2031	CDD:444066	24/178 (13%)
		SP1-4_N	2486..>2819	CDD:425404
ISW2	NP_014948.1	PLN03142	1..1093	CDD:215601	348/1736 (20%)