Protein Alignment dom and RAD16

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_009672.1
• Gene: RAD16 / 852411
• SGDID: S000000318
• Length: 790
• Species: Saccharomyces cerevisiae
• Alignment Length: 1200
• Identity: 224/1200 - (18%)
• Similarity: 384/1200 - (32%)
• Gaps: 540/1200 - (45%)

  Fly   711 AEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLEN-RDKLMKEEQSSAIKTETPDDSDDSEF- 773
            :::|.| ||...|...|               |..|| .|...:|.:..|...::||| ||.:|
Yeast    25 SDDDTA-VKNSKTLQLK---------------GNSENVNDSQDEEYRDDATLVKSPDD-DDKDFI 72

  Fly   774 -----EAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKL 833
                 ..||.:..||||.:.:.:.::.|:.|:|.|..:.|..|:.::.....|.::..|.|::
Yeast    73 IDLTGSDKERTATDENTHAIKNDNDEIIEIKEERDVSDDDEPLTKKRKTTARKKKKKTSTKKK-- 135

  Fly   834 APRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGA 898
                        |..|...|.:.....|...:|..|.||
Yeast   136 ------------SPKVTPYERNTLRLYEHHPELRNVFTD-------------------------- 162

  Fly   899 AGSGSTAGASGNKDDMLNDAAALA--ESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLV 961
                            |.:|....  .|.||.|.|:..      :||.|:         ||.||:
Yeast   163 ----------------LKNAPPYVPQRSKQPDGMTIKL------LPFQLE---------GLHWLI 196

  Fly   962 TMNER-KLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPG-F 1024
            :..|. ...|:||||||:||||||||||.:....    .|.|:|.|:..::.|:.|.::...| .
Yeast   197 SQEESIYAGGVLADEMGMGKTIQTIALLMNDLTK----SPSLVVAPTVALMQWKNEIEQHTKGQL 257

  Fly  1025 KILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVV----QDQQSFRRKKWKY------------ 1073
            ||..|:|:.:...:|.:     ..:.|.:|:|.::.    :....||||...:
Yeast   258 KIYIYHGASRTTDIKDL-----QGYDVVLTTYAVLESVFRKQNYGFRRKNGLFKQPSVLHNIDFY 317

  Fly  1074 -LILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREF--- 1134
             :|||||.|||:.:|...:.:.|..|::|..|:||||||.:.|::||:.||....|:.:  |
Yeast   318 RVILDEAHNIKDRQSNTARAVNNLKTQKRWCLSGTPLQNRIGEMYSLIRFLNINPFTKY--FCTK 380

  Fly  1135 -----KEW-FSNPM------TGMIEGNMEYNETLITRLHK----------------VIRPFLLRR 1171
                 |:| |::.|      ..:::....:|..::..:.|                :::..:|||
Yeast   381 CDCASKDWKFTDRMHCDHCSHVIMQHTNFFNHFMLKNIQKFGVEGPGLESFNNIQTLLKNIMLRR 445

  Fly  1172 LKKEVEKQ----MPKKYEHVITCR---LSNRQRYLYEDFMSRAKTR------ETLQTGNLLSVIN 1223
            .|  ||:.    :|.:   ::|.|   .:..::.||....:.:|.:      |.:...|..::..
Yeast   446 TK--VERADDLGLPPR---IVTVRRDFFNEEEKDLYRSLYTDSKRKYNSFVEEGVVLNNYANIFT 505

  Fly  1224 VLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTM 1288
            ::.::|::.:||::...|  ::.|..|.|..    ::|.:...:                .|:.:
Yeast   506 LITRMRQLADHPDLVLKR--LNNFPGDDIGV----VICQLCNDE----------------AEEPI 548

  Fly  1289 TAYVSHK-SRLLAPPRKLIEDI--DTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASP 1350
            .:...|| .||..  ::.:|..  :...|..|.|       ||.: |.:|:|            |
Yeast   549 ESKCHHKFCRLCI--KEYVESFMENNNKLTCPVC-------HIGL-SIDLSQ------------P 591

  Fly  1351 AMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLS 1415
            |:.::
Yeast   592 ALEVD------------------------------------------------------------ 596

  Fly  1416 NSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVT 1480
                                                                             
Yeast   597 ----------------------------------------------------------------- 596

  Fly  1481 ASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAAL 1545
                                                                         |.:.
Yeast   597 -------------------------------------------------------------LDSF 600

  Fly  1546 KRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLK 1610
            |:.::::|                                                   ||
Yeast   601 KKQSIVSR---------------------------------------------------LN---- 610

  Fly  1611 SFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPII 1675
                                               .|..||...:||.:|::..
Yeast   611 -----------------------------------MSGKWQSSTKIEALVEELY----------- 629

  Fly  1676 SEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLD 1740
                              ||::..|.::.        ::|:|.|.|||::|..|...|...::|.
Yeast   630 ------------------KLRSNKRTIKS--------IVFSQFTSMLDLVEWRLKRAGFQTVKLQ 668

  Fly  1741 GSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRI 1805
            ||....||...::.|..:.:...|::|.::|||.:||..|..|...|..|||:::.|:.||.|||
Yeast   669 GSMSPTQRDETIKYFMNNIQCEVFLVSLKAGGVALNLCEASQVFILDPWWNPSVEWQSGDRVHRI 733

  Fly  1806 GQTRDVHIYRLVSERTIEVNIL----KKAN 1831
            ||.|.|.|.|...|.:||..|:    ||||
Yeast   734 GQYRPVKITRFCIEDSIEARIIELQEKKAN 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727
		HepA	692..>1235	CDD:440319	139/595 (23%)
		DEXQc_SRCAP	949..1171	CDD:350761	74/271 (27%)
		SF2_C_SNF	1685..1817	CDD:350180	43/131 (33%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	47/133 (35%)
		HEC1	<1858..>2031	CDD:444066
		SP1-4_N	2486..>2819	CDD:425404
RAD16	NP_009672.1	HepA	<172..769	CDD:440319	180/979 (18%)
		RING-HC_RAD16-like	536..584	CDD:438229	12/72 (17%)