Protein Alignment dom and SWR1

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_010621.1
• Gene: SWR1 / 851934
• SGDID: S000002742
• Length: 1514
• Species: Saccharomyces cerevisiae
• Alignment Length: 1481
• Identity: 515/1481 - (34%)
• Similarity: 734/1481 - (49%)
• Gaps: 376/1481 - (25%)

  Fly   554 HWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAR 618
            |.|:|:.:.:.::..|....|.:...|||.::|::::|:..|.|.:|..|.:|...|.:|.|..:
Yeast   351 HTDHLINQGIHMSKLFRSSTKARIARAKKVSQMIEQHFKHVAGAEERKAKEEERHKKSLARFAVQ 415

  Fly   619 EVKSFWSNVEKLVEYKHQTKIEEKRKQALD--QHLSFIVDQTEKFSQQLVEGMNKSVAD-----T 676
            .||..|:..||  .|:...|.||::.:.::  ||||.::::    |.||:|.....|.|     |
Yeast   416 AVKKRWNMAEK--AYRILRKDEEEQLKRIEGKQHLSKMLEK----STQLLEAQLNQVNDDGRSST 474

  Fly   677 PSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLP 741
            ||.:|:.:.|   |||||...|..:..||:     ||..|||..|.:..:.|: ...|:.||
Yeast   475 PSSDSNDVLS---ESDDDMDDELSTSSDED-----EEVDADVGLENSPASTEA-TPTDESLN--- 527

  Fly   742 PGYLENRDKLMKEEQSSAI-----KTETPDDSDDSEFEAKEAS--DDDENTISKQEEAEQEIDHK 799
              .::.::|......||.:     |.|.....|..|..:.|:|  ..:|::|....|.|.:.::.
Yeast   528 --LIQLKEKYGHFNGSSTVYDSRNKDEKFPTLDKHESSSSESSVMTGEESSIYSSSENESQNEND 590

  Fly   800 KEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEE 864
            :|.|:......||.  |..|.:.           :..|.:||..:|.|...|:.|.|: ..:|:.
Yeast   591 RESDDKTPSVGLSA--LFGKGEE-----------SDGDLDLDDSEDFTVNSSSVEGEE-LEKDQV 641

  Fly   865 DLSTV---KTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQ 926
            |.|..   :....:..|:|..|.:|.:..||:.                               :
Yeast   642 DNSAATFERAGDFVHTQNENRDDIKDVEEDAET-------------------------------K 675

  Fly   927 PKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHL 991
            .:...||..:|  |||.||:.:||.||..||:||.::.....|||||||||||||||||:|||:|
Yeast   676 VQEEQLSVVDV--PVPSLLRGNLRTYQKQGLNWLASLYNNHTNGILADEMGLGKTIQTISLLAYL 738

  Fly   992 ACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSY 1056
            ||.|.||||||||||:||:||||||||::.||||:||||||.::||.||.||.||:||||||.||
Yeast   739 ACEKENWGPHLIVVPTSVLLNWEMEFKRFAPGFKVLTYYGSPQQRKEKRKGWNKPDAFHVCIVSY 803

  Fly  1057 KLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMH 1121
            :||||||.||:||:|:|::||||.|||||:|.|||.||||:|:||||||||||||:|.|||||::
Yeast   804 QLVVQDQHSFKRKRWQYMVLDEAHNIKNFRSTRWQALLNFNTQRRLLLTGTPLQNNLAELWSLLY 868

  Fly  1122 FLMPYV---------FSSHREFKEWFSNPMTGMIE-----GNMEYNETLITRLHKVIRPFLLRRL 1172
            ||||..         |:....|::||..|:..:||     |..:..:..:.:||:|:||:|||||
Yeast   869 FLMPQTVIDGKKVSGFADLDAFQQWFGRPVDKIIETGQNFGQDKETKKTVAKLHQVLRPYLLRRL 933

  Fly  1173 KKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNM 1237
            |.:||||||.||||::.|:||.|||:||:||||||:|:.||.:||.:|::|.||||||||||||:
Yeast   934 KADVEKQMPAKYEHIVYCKLSKRQRFLYDDFMSRAQTKATLASGNFMSIVNCLMQLRKVCNHPNL 998

  Fly  1238 FEARPTISPFQMDGITFHTPRLVCDIMEY--------------DPFTQINLETLNLLLLHLEQTM 1288
            ||.||.::.|.::    |     |...:|              :...:::|:.|||:....::.:
Yeast   999 FEVRPILTSFVLE----H-----CVASDYKDVERTLLKLFKKNNQVNRVDLDFLNLVFTLNDKDL 1054

  Fly  1289 TAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMR 1353
            |:|.:.:...|...:..:|:::                .:|..:.:|.:.
Yeast  1055 TSYHAEEISKLTCVKNFVEEVN----------------KLRETNKQLQEE--------------- 1088

  Fly  1354 LEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSK 1418
                                                                             
Yeast  1089 ----------------------------------------------------------------- 1088

  Fly  1419 LLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTAST 1483
             .|..|.:|          .||...:|..:
Yeast  1089 -FGEASFLN----------FQDANQYFKYS----------------------------------- 1107

  Fly  1484 TSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRM 1548
                                   .||                   |::..:.|        |..:
Yeast  1108 -----------------------NKQ-------------------KLEGTVDM--------LNFL 1122

  Fly  1549 AMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFE 1613
            .|:|:.|.|..||:|::..:.:.:    .|.:|..                ::....|.|:|..:
Yeast  1123 KMVNKLRCDRRPIFGKNLIDLLTK----DRRVKYD----------------KSSIIDNELIKPLQ 1167

  Fly  1614 ERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLAL-------- 1670
            .|..|.:.:...|.:..||..:..:|:....|:.         ::.|.:..|.|:..
Yeast  1168 TRVLDNRKIIDTFAVLTPSAVSLDMRKLALGLND---------DSSVGENTRLKVMQNCFEVSNP 1223

  Fly  1671 LHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHI 1735
            ||.:.:::|..|||..|:||||||||.:..||:|||.||||.||||||||:|||||.||||||::
Yeast  1224 LHQLQTKLTIAFPDKSLLQYDCGKLQKLAILLQQLKDNGHRALIFTQMTKVLDVLEQFLNYHGYL 1288

  Fly  1736 YLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQD 1800
            |:||||:|::|.||||.||||.|.||..||||:||||:|||||||||||||||||||.||.|.||
Yeast  1289 YMRLDGATKIEDRQILTERFNTDSRITVFILSSRSGGLGINLTGADTVIFYDSDWNPAMDKQCQD 1353

  Fly  1801 RCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQS 1865
            |||||||||||||||.|||.|||.||||||||||.|.::.|:.|:|||.||...:::||...|..
Yeast  1354 RCHRIGQTRDVHIYRFVSEHTIESNILKKANQKRQLDNVVIQEGDFTTDYFSKLSVRDLLGSELP 1418

  Fly  1866 EQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAA 1930
            | :.|..:|....|..||.               :..|..|..||.||||.||:|...|..||..
Yeast  1419 E-NASGGDKPLIADADVAA---------------KDPRQLERLLAQAEDEDDVKAANLAMREVEI 1467

  Fly  1931 DLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFV 1981
            |..:|||    :||...|.   :.|.:.|:|:.   .:..:.::.|.:||:
Yeast  1468 DNDDFDE----STEKKAAN---EEEENHAELDE---YEGTAHVDEYMIRFI 1508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	16/59 (27%)
		HepA	692..>1235	CDD:440319	249/566 (44%)
		DEXQc_SRCAP	949..1171	CDD:350761	145/235 (62%)
		SF2_C_SNF	1685..1817	CDD:350180	102/131 (78%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	140/233 (60%)
		HEC1	<1858..>2031	CDD:444066	36/124 (29%)
		SP1-4_N	2486..>2819	CDD:425404
SWR1	NP_010621.1	HSA	340..>393	CDD:214727	10/41 (24%)
		HepA	<649..1393	CDD:440319	382/1006 (38%)
		DEXQc_SRCAP	696..932	CDD:350761	145/235 (62%)