DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dom and PIE1

DIOPT Version :9

Sequence 1:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster
Sequence 2:	NP_187887.3	Gene:	PIE1 / 820463	AraportID:	AT3G12810	Length:	2055	Species:	Arabidopsis thaliana

Alignment Length:	2220	Identity:	719/2220 - (32%)
Similarity:	997/2220 - (44%)	Gaps:	671/2220 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   502 GGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLA 566
            ||...|:......|.|:|.:     ..|..:|     ::.|...:||.|||.|||::||||.||:
plant     5 GGKSKPDIVMASKSGKSKPD-----NESRAKR-----QKTLEAPKEPRRPKTHWDHVLEEMAWLS 59

  Fly   567 ADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLV 631
            .||..|||||...|||.|....|...|:|:..:|..|.:|.:|::||..|::::|.||..|||||
plant    60 KDFESERKWKLAQAKKVALRASKGMLDQASREERKLKEEEQRLRKVALNISKDMKKFWMKVEKLV 124

  Fly   632 EYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVE--------GMN---------KSVAD---- 675
            .||||....||:|:|:|:.|.|::.|||::|..|.|        |.|         :|.:|
plant   125 LYKHQLVRNEKKKKAMDKQLEFLLGQTERYSTMLAENLVEPYKQGQNTPSKPLLTIESKSDEERA 189

  Fly   676 ---TPSLNSS---RLTSPKRESDDDFRPESGSEDDEETIAKAEED-----AADVKEEVTALAKES 729
               .|.:|||   ...||:.:.|.|.:.|..:||||:||   |||     ..:.:||:.||..|.
plant   190 EQIPPEINSSAGLESGSPELDEDYDLKSEDETEDDEDTI---EEDEKHFTKRERQEELEALQNEV 251

  Fly   730 EMDFDDFLNDLPPGYL---------ENRDKLMKEEQ-SSAIKTETPDD---------SDDSEFEA 775
            ::..::.|.....|.:         ||.|.|....: :|.:|.|..|:         .|.:...|
plant   252 DLPVEELLRRYTSGRVSRETSPVKDENEDNLTSVSRVTSPVKDENQDNLASVGQDHGEDKNNLAA 316

  Fly   776 KEASD------------------------------------------------------------ 780
            .|.::
plant   317 SEETEGNPSVRRSNDSYGHLAISETHSHDLEPGMTTASVKSRKEDHTYDFNDEQEDVDFVLANGE 381

  Fly   781 --DDENTISKQEE---AEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPEL 840
              |||.|::.:||   |:.| ||.:||..|:.::::.:|.|||:||.:         ...:|...
plant   382 EKDDEATLAVEEELAKADNE-DHVEEIALLQKESEMPIEVLLARYKED---------FGGKDISE 436

  Fly   841 DSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTA 905
            |..:.|.||     |||:..:.:|:    :...|::  |:..|..:..:.....:....|:....
plant   437 DESESSFAV-----SEDSIVDSDEN----RQQADLD--DDNVDLTECKLDPEPCSENVEGTFHEV 490

  Fly   906 GASGNKD--DMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKL 968
            ....:||  |.:.||||.|.|.||.|.|.|:|.|.|.:||||||||||||||||||||||.|:||
plant   491 AEDNDKDSSDKIADAAAAARSAQPTGFTYSTTKVRTKLPFLLKHSLREYQHIGLDWLVTMYEKKL 555

  Fly   969 NGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQ 1033
            ||||||||||||||.||||||||||.||.|||||||||:|||||||.||.||||.||||||:||.
plant   556 NGILADEMGLGKTIMTIALLAHLACDKGIWGPHLIVVPTSVMLNWETEFLKWCPAFKILTYFGSA 620

  Fly  1034 KERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFST 1098
            |||||||.||.|.|:||||||:|:||:||.:.|:||||||||||||..|||:||||||.||||::
plant   621 KERKLKRQGWMKLNSFHVCITTYRLVIQDSKMFKRKKWKYLILDEAHLIKNWKSQRWQTLLNFNS 685

  Fly  1099 ERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKV 1163
            :||:|||||||||||||||||||||||:||.||:|||:||.||:.||:||..:.|:.:|.|||.|
plant   686 KRRILLTGTPLQNDLMELWSLMHFLMPHVFQSHQEFKDWFCNPIAGMVEGQEKINKEVIDRLHNV 750

  Fly  1164 IRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQL 1228
            :|||||||||::||||:|.|:||||.||||.|||.|||||::..:|:.||.:|:...:|:::|||
plant   751 LRPFLLRRLKRDVEKQLPSKHEHVIFCRLSKRQRNLYEDFIASTETQATLTSGSFFGMISIIMQL 815

  Fly  1229 RKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVS 1293
            |||||||::||.||.:|.|.|.||.......:|.::...||::::||.|..|..||:.:||::..
plant   816 RKVCNHPDLFEGRPIVSSFDMAGIDVQLSSTICSLLLESPFSKVDLEALGFLFTHLDFSMTSWEG 880

  Fly  1294 HKSRLLAPPRKLI-------EDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPA 1351
            .:.:.::.|.:||       :|::..||                                  ||.
plant   881 DEIKAISTPSELIKQRVNLKDDLEAIPL----------------------------------SPK 911

  Fly  1352 MR--LEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVL 1414
            .|  |:|:.|..                       .::..|....:..:.....|.:...:|
plant   912 NRKNLQGTNIFE-----------------------EIRKAVFEERIQESKDRAAAIAWWNSL--- 950

  Fly  1415 SNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTV 1479
                    |.|               .||.:                          :|:.||.:
plant   951 --------RCQ---------------RKPTY--------------------------STSLRTLL 966

  Fly  1480 TASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAA 1544
            |         |:.|: .||..:..|.:....:|:....|.|..:     |:.||:
plant   967 T---------IKGPL-DDLKANCSSYMYSSILADIVLSPIERFQ-----KMIELV---------- 1006

  Fly  1545 LKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLL 1609
                                   ||....:.|.|....:.|.::..:
plant  1007 -----------------------EAFTFAIPAARVPSPTCWCSKSDS------------------ 1030

  Fly  1610 KSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPI 1674
                       |||.:     ||                   :::::.::    |.|.|:.:.|.
plant  1031 -----------PVFLS-----PS-------------------YKEKVTDL----LSPLLSPIRPA 1056

  Fly  1675 ISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRL 1739
            |......|||.||||:||||||.:..|||:||..|||.||||||||||||||||:|.:|:.|:||
plant  1057 IVRRQVYFPDRRLIQFDCGKLQELAMLLRKLKFGGHRALIFTQMTKMLDVLEAFINLYGYTYMRL 1121

  Fly  1740 DGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHR 1804
            ||||..|:||.||:|||.:.:||.||||||||||||||.||||||||||||||.||.||||||||
plant  1122 DGSTPPEERQTLMQRFNTNPKIFLFILSTRSGGVGINLVGADTVIFYDSDWNPAMDQQAQDRCHR 1186

  Fly  1805 IGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDE 1869
            |||||:||||||:||.|||.||||||||||:|.::.|:.|.:.|.:||.....:||:..::...:
plant  1187 IGQTREVHIYRLISESTIEENILKKANQKRVLDNLVIQNGEYNTEFFKKLDPMELFSGHKALTTK 1251

  Fly  1870 SSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAADLAE 1934
            ..:|.|::..        :|.|.:..:.|.        ||..||||.|..|.|..:.|.|.|..|
plant  1252 DEKETSKHCG--------ADIPLSNADVEA--------ALKQAEDEADYMALKRVEQEEAVDNQE 1300

  Fly  1935 F----------DENI---PIATEDPNAEG----GP---QVELSKADLEMQNLV------------ 1967
            |          ||.:   .|..::|..:|    ||   ::.|..:|:..:..|
plant  1301 FTEEPVERPEDDELVNEDDIKADEPADQGLVAAGPAKEEMSLLHSDIRDERAVITTSSQEDDTDV 1365

  Fly  1968 ----------------------KQLSPIERYAMRFVEETGAAWTAEQLRAA-EAELEAQKREWEA 2009
                                  .||.||:|||:||:|    .|....:.|| |.|...:::|||.
plant  1366 LDDVKQMAAAAADAGQAISSFENQLRPIDRYAIRFLE----LWDPIIVEAAMENEAGFEEKEWEL 1426

  Fly  2010 NRLAAMHKEEELLKQETEA-----EEMLTYSRKDS---------SNQVWISRNTMEQMP------ 2054
            :.:       |..|:|.||     ||.|.|.:.|:         ..:|......||.:.
plant  1427 DHI-------EKYKEEMEAEIDDGEEPLVYEKWDADFATEAYRQQVEVLAQHQLMEDLENEARER 1484

  Fly  2055 --------------------------------------------------MWCPPTPPQDNDNDI 2069
                                                              :....:...||:...
plant  1485 EAAEVAEMVLTQNESAHVLKPKKKKKAKKAKYKSLKKGSLAAESKHVKSVVKIEDSTDDDNEEFG 1549

  Fly  2070 YIDYS-------LSFMY----ELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYV 2123
            |:..|       ||.|:    :.:.|.:||        |.|.|:..|.......||.   :..|.
plant  1550 YVSSSDSDMVTPLSRMHMKGKKRDLIVDTD--------EEKTSKKKAKKHKKSLPNS---DIKYK 1603

  Fly  2124 PPRSLFD-----RPTPQLARLRRELKSQRFRG-----SFKPNMPIPGLKPQLPTKP--------- 2169
            ...:|.|     :|:..:. :..|||... ||     .|..:|||   |..|..||
plant  1604 QTSALLDELEPSKPSDSMV-VDNELKLTN-RGKTVGKKFITSMPI---KRVLMIKPEKLKKGNLW 1663

  Fly  2170 ----LTEPEAMAEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKT----- 2225
                :..|::   |...|| |||..:|:..|             |||       ||.|.|
plant  1664 SRDCVPSPDS---WLPQED-AILCAMVHEYG-------------PNW-------NFVSGTLYGMT 1704

  Fly  2226 --------YRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVS 2282
                    ||....|..||...|| |......:|...:|.|........||.....:||. |.|:
plant  1705 AGGAYRGRYRHPAYCCERYRELIQ-RHILSASDSAVNEKNLNTGSGKALLKVTEENIRTL-LNVA 1767

  Fly  2283 DNNASFYKTMRSRFDSIKTAYLK-------------KAPPPKRQFSAPSLMNPKHMEVLQEFGIL 2334
            .........::..|..:.::..:             .:|...|||                .|.:
plant  1768 AEQPDTEMLLQKHFSCLLSSIWRTSTRTGNDQMLSLNSPIFNRQF----------------MGSV 1816

  Fly  2335 NYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQQQQPQQV 2399
            |:.|.::.:....||...:..|                  :.:.:.|...|:        ||...
plant  1817 NHTQDLARKPWQGMKVTSLSRK------------------LLESALQDSGPS--------QPDNT 1855

  Fly  2400 VQQVQQQQQQ 2409
            :.:.:.|:.|
plant  1856 ISRSRLQETQ 1865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	33/70 (47%)
		ASF1_hist_chap	<674..831	CDD:304562	56/255 (22%)
		FAM176	<824..>868	CDD:291517	9/43 (21%)
		SNF2_N	952..1238	CDD:278600	211/285 (74%)
		DEXDc	969..1108	CDD:238005	110/138 (80%)
		Helicase_C	1692..1806	CDD:278689	86/113 (76%)
PIE1	NP_187887.3	HSA	36..106	CDD:214727	32/69 (46%)
		HepA	<529..1230	CDD:223627	413/914 (45%)
		DEXQc_SRCAP	536..758	CDD:350761	173/221 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	434	1.000	Domainoid score	I109
eggNOG	1	0.900	-	-		E2759_KOG0391
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H135030
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188211at2759
OrthoFinder	1	1.000	-	-		FOG0001654
OrthoInspector	1	1.000	-	-		oto3310
orthoMCL	1	0.900	-	-		OOG6_101779
Panther	1	1.100	-	-	LDO	PTHR45685
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2889
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.780