|
Fly 9 GGHEGLSPAPPAVPDRVTP------------H----------------STEISVAPANSTSTTVR 45
||::.::.||..:|:..:| | .|:....|:.....|::
Mouse 83 GGNQQITLAPLPLPNPTSPGFQFGAQQRRFEHGSPSYIQVTSPMSQQVQTQSPTQPSPGPGQTLQ 147
Fly 46 --AAGSVGAAL------------------------PATRHHQHIATQVKGIASSSSKQQKQLASA 84
.||:.|..| |::..| .:..:..|:...:...|.||..:
Mouse 148 NVRAGAPGPGLGICSNSPTGGFVDASVLVRQISLSPSSGGH-FVFQEAPGLTQMAQGAQVQLQHS 211
Fly 85 QLPVPLSP--LPQQQQQTA--------EATAAA--------AAPAHSNVSVSSSTIEASVLPPQ- 130
..|:.:.. |.|...|:. ::.||| |:|.| |..:.||||
Mouse 212 GAPITVRERRLSQPHAQSGGTIHHLGPQSPAAAGGTGLQPLASPNH---------ITTASLPPQI 267
Fly 131 ---------AKRQRLDDNE--------DRTSAASI--VGPAESSNIVSSLLPASVASSSEVGGLS 176
.::|::...: :||....: ||...:..:.|...|.|.:.::...|||
Mouse 268 SSIIQGQLIQQQQQVLQGQPMNRSLGFERTPGVLLPGVGGPSAFGMTSPPPPTSPSRTTMPPGLS 332
Fly 177 STAL----------------------QDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQN-G 218
|..| |::..::|:.|....:.:..|||...|.:.|.|:||: .
Mouse 333 SVPLTSMGSSGMKKVPKKLEEIPPASQEMAQMRKQCLDYHYKEMEALKEVFKEYLIELFFLQHLQ 397
Fly 219 GSMMDYPAWRKKTPTPQFISYSNANRIDQLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSG 283
|:|||:.|::||...| ..:|...|.:|....|::.......:...|.:: .|:..|||.|
Mouse 398 GNMMDFLAFKKKHYAP-LQAYLRQNDLDIEEEEEEEEEEEGKSEVINDEH-----QSLTGSLVVG 456
Fly 284 IGT------------------------------------GATKGAPL-------DGNISNSTVKT 305
.|: |...|.|| .|.:..:...|
Mouse 457 PGSATEADPFKRQQVMPPTEQSKRPRLEVGHPGVVFQHPGVNAGVPLQQLMPTVQGGMPPTPQAT 521
Fly 306 NTQSQVPSKIGSFTESTPAATESNSS--------------TTVPGTA-TSGAATSTSATSAEASG 355
....|..|: ..:..||....::.:| .:||.|| .|....|..:...|||
Mouse 522 QLTGQKQSQ-QQYDPSTGPPVQNAASLHTPPPQLPARLPPASVPATALPSTLQFSQQSQMVEAS- 584
Fly 356 NVLAVEAEIKIPAV-----GATPVAISTKLPAAVVQLTQQG-HIPGRPLGGRHGMVFGQIPAPPA 414
.:::||.. ...|..:.::|||...|..|.. |: |:.|:..|...|:.:...
Mouse 585 ------TQLQIPVKTQQLNAPIPAPLPSQLPAPSSQPAQPALHV---PMPGKAQMQTSQLSSQTQ 640
Fly 415 AVGNPSVPLVPGGTPLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTGNGPA-- 477
.|.:...|| ....||..|..: :::||.....||.|...:|......|.|:
Mouse 641 TVASTRPPL----DSAQPCQRSLPT---------SSSSSSLVPVSGSGPGPSPARSSPVNRPSSA 692
Fly 478 ---ALGGSGGLTPGTPTSG--SLLSPALGGGS---GTPNSAAQEFSFKAKQEVYVMQRISELQRE 534
||......:||...|. ...|||....| |:.:..|::.:. |..:.|||::|::|
Mouse 693 TNKALSPITSRSPGVAVSAPPKPQSPAQNAASSQDGSQDKLAEQITL----ENQIHQRIADLRKE 753
Fly 535 GLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQ 599
|||:.||||||||..|||:|||||||||.|:|.||||||:||..||||..:.|.::.::|....:
Mouse 754 GLWSLRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKLAAAKKLVRTVARHHEEKKLREE 818
Fly 600 RAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQ 664
|.:|.::.:|:|:|:..|||::.||||:|::||.|.|.::|||||:||: .:|.|::
Mouse 819 RGKKEEQSRLRRIAATTAREIEYFWSNIEQVVEIKLQVELEEKRKKALN---------LQKVSRR 874
Fly 665 LVEGMNKSVADTP--SLNSSRLTSPKRE-----SDDDFRPESGSEDDEETI--AKAEEDAADVKE 720
..|...|....:| ||:.. ::..||: :||:. ||:|||| .:|.|...|...
Mouse 875 GKESRLKGFDTSPEHSLDLG-ISGRKRKASTSLTDDEV------EDEEETIEEEEAHEGLVDHHT 932
Fly 721 EVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENT 785
|:|.||||:|:...|.:......:|.| |:..:...|.|.:
Mouse 933 ELTNLAKEAELPLIDLMKLYEGAFLPN-------------------------FQWPQPEPDHEES 972
Fly 786 ISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVD 850
|.:|:.|. .|.|.| |..||..:|
Mouse 973 -SGEEDVED---------------------------------------CPSDRE--SRRDSVLID 995
Fly 851 STEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDML 915
| :...|:.: |....:.|.|..|| :
Mouse 996 S-----------------------LFIMDQFK----------------AAERMSIGKSNTKD--I 1019
Fly 916 NDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGK 980
.:..|:||::.|||:...:|.|....|.||..:||:||.||||||..:..:.||||||||.||||
Mouse 1020 TEVTAVAEAILPKGSARVTTAVKFSAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGK 1084
Fly 981 TIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTK 1045
|:|.||..|||||.:|||||||:|:.|..:|.||:|.|:||||.|.|:|.||.:|.|.||..||:
Mouse 1085 TVQIIAFFAHLACNEGNWGPHLVVMRSCNILKWELELKRWCPGLKTLSYVGSHRELKAKRQEWTE 1149
Fly 1046 PNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQ 1110
||.||:||||||...:...:|.|..||.|::||.|.:|....:.|:.:....:::||||...||.
Mouse 1150 PNNFHICITSYKQFFRGYTAFSRVHWKCLVVDEMQRVKGMTERHWEAIFKLQSQQRLLLIDVPLH 1214
Fly 1111 NDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKE 1175
|..:|||:::|||:|.: .:.:.|.|:....|.|.:|...::.|||:|.:||:|||.|::
Mouse 1215 NTFLELWTMVHFLIPGI------SRPYLSFPLKAPNEENQDYYHKMVIRLHRVTQPFILRRTKRD 1273
Fly 1176 VEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEA 1240
||||:.:|||||:.||||:||:.||||.:.:.:|:|.|::|:.:||::||.:|:::||||.:.|.
Mouse 1274 VEKQLTRKYEHVLKCRLSSRQKALYEDVILQPRTQEALKSGHFVSVLSVLTRLQRICNHPGLVEP 1338
Fly 1241 RPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAP---P 1302
|...|.|....:.:.:..|:..::|.:.:.:.:|...: |:.||..:| .|::.||.. .
Mouse 1339 RVPGSSFAAGSLQYKSASLILRVLEREFWKETDLSIFD--LIGLENKIT---RHEAELLCKKKVT 1398
Fly 1303 RKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIM-----PM 1362
|||:|::..:|.|:.| |.. ::::::.|.| .|:.|..| ||..:. |.
Mouse 1399 RKLMEEVFASPPPSAR-PAA-----VKLKASRLFQ-----PVQYGQKP----EGRTVAFPSTHPP 1448
Fly 1363 R-------NLLPSGRVLKR---VSASINPVNMALKPVVINSVVTTTSSSTTASSP--------TG 1409
| ...|.|:|..| .:.|.||.....:.|.|..:.:.....:..:.| .|
Mouse 1449 RMANTNTSTATPQGQVRGRPPIATFSANPDTKGGEVVKIAQLASIAGPQSRVAQPETPVTLQFQG 1513
Fly 1410 ALSVLSNSKLLGARSQINAPTPAKVAKTM-----QDGKPFFY----LTPATNSGAAGARLTLTSK 1465
....||:|:| .|:.|..|.::..:: ..|:|:.. :...|.|.|.....||.||
Mouse 1514 NKFTLSHSQL----RQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHSTLGSK 1574
Fly 1466 TTASAST---------TTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEE 1521
...|..: ...|..|:|.......|...| .|.|.|.|:.|:.
Mouse 1575 PPTSGPSPAPLTPQVGVPGRVAVSAMAVGEPGLASKP---------------ASPAAGPTQEEKS 1624
Fly 1522 TEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQ 1586
::.||: |.::..||.||....|:|| |:.::.|....|..:...|.
Mouse 1625 -------------RLLKER----LDQIHFINERRCSQAPVYG---RDLLRICSLPGRRKRPLCWS 1669
Fly 1587 --------TRGYANCCTAMAHRNGWSLNHLLKSFEERCAD--------LKPVFAN----FVIYVP 1631
.:| .|...:::...| :.:|...:|...| :.||.|. :|...|
Mouse 1670 LDSNFGKGPKG-VNYDMSLSKSEG---DLILTLSQESLQDVLGRVACVIPPVVATPPSLWVARPP 1730
Fly 1632 SVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQ 1696
|:.:.|:|...|.|......:.::::.:. ||| :.:||:.||:|:|.|||:
Mouse 1731 SLYSSRLRALRQCLREHTGPYHRQLQQLT--ALR-------------SLQFPELRLVQFDSGKLE 1780
Fly 1697 TMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRI 1761
.:..||::||..|.||||.:||..|||:||.|||:|...|:|:|.:...||||.||..||.|:||
Mouse 1781 ALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFHYLTYVRIDENANSEQRQELMRSFNRDRRI 1845
Fly 1762 FCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNI 1826
||.:|||.|...||||..||||:|||:|.||.|||:||:.|.|||:.:|:|||||||..:||..:
Mouse 1846 FCALLSTHSRATGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKL 1910
Fly 1827 LKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTP 1891
||... |.::.::|.:|.:::..:....||::||.:.....|.....|:|. ...||..|
Mouse 1911 LKNGT-KDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDTGFPVKAEE------FVVLSQEP 1968
Fly 1892 STVVETEKQSLRAFEHALAAAED-EQDVQ-ATKTA---KAEVA----ADLAEFDENIPIATEDPN 1947
|.......:..|.|..||.:.|. |:|.| :|:.| .:.|| :|.:.:| |:|:
Mouse 1969 SVSETIAPKIARPFIEALKSIECLEEDAQRSTEEAVPGSSSVAVSSDSDGSRYD-------EEPS 2026
Fly 1948 AEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEANRL 2012
|:| |:.:.::||:|||:||:.::|........|:.|.:|..:.|..::||....
Mouse 2027 -----QLE------ELADFMEQLTPIEKYALNYLELFHTTTEQEKERISEDLVMASMKDWETRNA 2080
Fly 2013 AAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNT---MEQMPMWCPPTPPQDNDNDIYIDYS 2074
.|:.:.|..|:.|.|..|:|||:|:|:....::..:. .|.||:|.||||||| |||||||..
Mouse 2081 RALQEREARLQLEQEEAELLTYTREDAYTMEYVYEDADGQTEVMPLWTPPTPPQD-DNDIYIDSV 2144
Fly 2075 LSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQLARL 2139
:..|||..||.|..|||||||||.||.:||....| |..|.|..:..|||||||||.||.:.::
Mouse 2145 MCLMYETTPIPEAKLPPVYVRKERKRHKTDPSAAG--RKKKQRHGEAVVPPRSLFDRATPGMLKI 2207
Fly 2140 RRELKSQRFRGSFKPNMPIPGLKPQLPT--KPLTEP-EAMAEWCVFEDMAILHVLVNLQGLPCSL 2201
|||.|.|:.....|...|. .|| ||| |...|| :...:|.:.||.|:|..:..|..||.:|
Mouse 2208 RREGKEQKKNLLLKQQTPF--AKP-LPTYVKSSGEPAQDSPDWLIGEDWALLQAVKQLLELPLNL 2269
Fly 2202 MLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTLRTEY 2266
.::||..||||||||::||.||:.|||::|||.|||..|.||||| |.|..:|
Mouse 2270 TIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEG-------KSKNNRP------ 2321
Fly 2267 LKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSA-PSLMNPKHMEVLQE 2330
|||:|:|..|.||:..:...|.|:.:|....|::||.|..... |...||||..||.|
Mouse 2322 -------LRTSQIYAQDENATHTQLYTSHFELMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAE 2379
Fly 2331 FGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPPLPQQQQ 2395
.|| |||:|:.|..:|:::|.:|.::::. :..|.:.||.|...|.|||||
Mouse 2380 SGI-NYDKPLPPIQVASLRAERIAKEKKA---------------LADQQKAQQPPVTQPPPQQQQ 2428
Fly 2396 PQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQ 2460
.| ||||||||||||.....||.|. ||.| |.|
Mouse 2429 QQ------QQQQQQQQQQQQPPPPPQQPPP--------PVPQ-----------------PQA--- 2459
Fly 2461 LQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTAGQLQQL 2525
:|:.:|..|.|: |||.|
Mouse 2460 ----------ASSQTPAGQPAV---QPQPQ----------------------------------- 2476
Fly 2526 AQQSAVASGGQSSVSVVLTTPVQTLPSVVQPQIGSGAQIVSISSQTL-PVNSSPQLGSIVQTQSL 2589
..|||.|..|||| |....|: .|.|:..|...::|.
Mouse 2477 -------------------PQVQTQPQPVQPQ--------SKGQPTMTTVGSAAVLAGTIKTS-- 2512
Fly 2590 PQVVSVSTLPTVGTV-----LTTTANQPQQQHQTTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTA 2649
|:.:::|| ||| :.|.|..|....|:. .:|:.|..|..|| ||:
Mouse 2513 ---VTGTSIPT-GTVSGNVIVNTIAGVPAATFQSI-----------NKRLASPVAPGTL---TTS 2559
Fly 2650 GGQSIVSMPNLGQGASPSQ-FQTQLRLAAVPTSPATQTTQLV---TTKGI--------------P 2696
| |::|:| ..||.|... ||||.||.|| ||:|: .
Mouse 2560 G------------GSAPAQVVHTQQRAVG---SPATATTDLVSMTTTQGVRAVTSVTASAVVTTN 2609
Fly 2697 VSALQQGGKTTVIPVTQQSG----------GAHIQLYR------QRSLKVLQTTTQAVPS-GSAG 2744
::.:|...::.|..|:|.:| .||.||.| |:..:..||:...||. .|..
Mouse 2610 LTPVQTPTRSLVTQVSQATGVQLPGKTITPAAHFQLLRQQQQQQQQQQQQQQTSQVQVPQLQSQA 2674
Fly 2745 ATGATANLVQAGGT--IIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSVQMHGQARTQFIK 2807
.:.|....|...|. ||:.......:..|.......||.. |...|.:.| ..
Mouse 2675 QSPAQIKAVSKLGPEHIIKMQKQKMQLPPQPPPPQAQPGPP------------QQPAQVQVQ-TP 2726
Fly 2808 QMAAGKQQLQRQVVSA-------DGTTTTTAAGDMLLVKRHNILAAQKAQQASGALFTTTTGQQQ 2865
|....:|..|...|:| .|||.| |:..|: |....|.|.|
Mouse 2727 QPPQQQQSPQLTTVTAPRPGALLTGTTVT------------NLQVAR--------LTRVPTSQLQ 2771
Fly 2866 QQQQQQGQLPVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSATNPTVQAG-SVNMTLP 2929
.|.|.|.|.| ||.||. :|.....|..||. |::.||| |.|...|| ||.:..|
Mouse 2772 AQGQMQTQTP---QPAQVA---LAKPPVVSVPAAV----VSSPGVT---TLPMNVAGISVAIGQP 2823
Fly 2930 QLKPGSQIKVTMPNQMRHLQMQQQLTMPRKISRMTQLV---SASGQPTATNIITTTGPQQQQQGV 2991
|...|..:.....|..:.|:.:||..:.::.:...|:. :|..|...|..|||.||||:....
Mouse 2824 QKTAGQTVVAQPVNVQQLLKYKQQTAVQQQKAIQPQVAQGQAAVQQKLTTQQITTQGPQQKVAYA 2888
Fly 2992 TVSGGGT--LPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLSNSVTMQQIQQVMRSGQQGT 3054
......| |.|..|| .||:.|...||.|:...:..:.:.....:..||||..:.||.:
Mouse 2889 AQPALKTQFLTTPISQ------AQKLAGTQQVQTQIQVAKLPQVVQQQTPVASIQQVASASQQAS 2947
Fly 3055 LATTNLVLGKTSVG---RVIP-VSVASQANQRQTI--QVVSAASAQALAAGNLRTHVAGPSIAST 3113
..|..|... |:.| ::|| |:..:|..|::.| |||:.|||.....| |||.|.
Mouse 2948 PQTVTLTQA-TAAGQQVQMIPTVTATAQLVQQKLIQQQVVTTASASLQTPG-------GPSPAQ- 3003
Fly 3114 LKVAAPGSAGGQTTQQTLIAALQHNQRQNASPVRLQT 3150
.|.|:...:.|..| :.....|||:|
Mouse 3004 ----LPASSDSPSQQPKL--------QMRVPAVRLKT 3028
| 
