DRSC/TRiP Functional Genomics Resources

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Protein Alignment dom and Ino80

DIOPT Version :10

Sequence 1:NP_001286676.1 Gene:dom / 45655 FlyBaseID:FBgn0020306 Length:3233 Species:Drosophila melanogaster
Sequence 2:NP_080850.2 Gene:Ino80 / 68142 MGIID:1915392 Length:1559 Species:Mus musculus


Alignment Length:1569 Identity:414/1569 - (26%)
Similarity:663/1569 - (42%) Gaps:441/1569 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   429 PLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTGNG---PAALGGSGGLTPGTP 490
            ||||   .:|...::..:...|:..|..:.:...|.|.|   |:.||   ..:....|.|...:.
Mouse    60 PLLP---ESGDPLIQVKEEPPNSLLGETSGASSSGLLNP---YSLNGVLQSESKSDKGNLYNFSK 118

  Fly   491 TSGS---LLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPK 552
            ...|   |.|..|...|...:|.::: :...::|:       .|.||.|....||.|.::..:.|
Mouse   119 LKKSRKWLKSILLSDESSEADSQSED-NDDEEEEL-------SLSREELHNMLRLHKYKKLHQNK 175

  Fly   553 AHWDYLLEEMVWLAA-------DFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLK 610
            ...|..|::..:.:|       .|.::::......||      |:.:||...|    |.::::.|
Mouse   176 YSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKK------KFKEDKKLKA----KLKKVKKK 230

  Fly   611 RVASFIAREVKSFWSNVEKLVEYKHQTKI------------EEKRKQALDQ--------HLSFIV 655
            |      |..:.| |:.|....:.||||:            .:|:..:::|        .||.:.
Mouse   231 R------RRDEEF-SSEESPRHHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNARRRKVWLSIVK 288

  Fly   656 DQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKE 720
            .:..|.::|      ||.|....|.:||..:.:...:.........::.:||:.:|..       
Mouse   289 KELPKANKQ------KSSARNLFLTNSRKLAHQCMKEVRRAALQAQKNCKETLPRARR------- 340

  Fly   721 EVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENT 785
                |.||..:            |.:..:|:.||.:..|            |.||.|....||  
Mouse   341 ----LTKEMLL------------YWKKYEKVEKEHRKRA------------EKEALEQRKLDE-- 375

  Fly   786 ISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVD 850
              :..||:::   :::::.|     ::..:|.|.:.|.     ||          |...|....:
Mouse   376 --EMREAKRQ---QRKLNFL-----ITQTELYAHFMSR-----KR----------DMGHDGIQEE 415

  Fly   851 STEESEDAATEDEEDL-STVKTDTDMEEQDEQEDGLKSL---------------MADADATSGAA 899
            ...:.||::|:.:.|: ..|..:...|:.|......::|               ..|.||....|
Mouse   416 ILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYHIHQARTRSFDEDAKESRA 480

  Fly   900 GSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMN 964
            .:...|..||:.   ..::.:||......|..:       |.|.:....|:.||..|::||..:.
Mouse   481 AALRAADKSGSG---FGESYSLANPSIRAGEDI-------PQPTIFNGKLKGYQLKGMNWLANLY 535

  Fly   965 ERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTY 1029
            |:.:|||||||||||||:|:||||||||..:..|||.||:.|:|.:.||..||.::.|.||:|.|
Mouse   536 EQGINGILADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLNNWHQEFTRFVPKFKVLPY 600

  Fly  1030 YGSQKERKLKRVGW------TKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQ 1088
            :|:..:||:.|..|      |:...|||.||||:|||||.:.|:|.||:|::|||||.:|:..|.
Mouse   601 WGNPHDRKVIRRFWSQKTLYTQDAPFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSV 665

  Fly  1089 RWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYN 1153
            ||::||.|....||||||||:||.:.|||:|:||:||.:|.||.||.||||..:....|.....:
Mouse   666 RWKILLQFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAID 730

  Fly  1154 ETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQT--- 1215
            |..::|||.:::||:|||:||:||.::..|.|.:..|:|::||:.||:...::....:.||:   
Mouse   731 ENQLSRLHMILKPFMLRRIKKDVENELSDKIEILTYCQLTSRQKLLYQALKNKISIEDLLQSSMG 795

  Fly  1216 ------GNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINL 1274
                  ....|::|::||.|||||||.:||.:.|.|||.:....:...:.:....:...|.....
Mouse   796 STQQAQNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYEISKFIYRHGQIRVFNHSRD 860

  Fly  1275 ETLNLLLL-----HLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIR-VRSA 1333
            ..|.:||.     :::|::                                     ||.: :...
Mouse   861 RWLKVLLSPFAPDYIQQSL-------------------------------------FHRKGINEG 888

  Fly  1334 ELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTT 1398
            .....::.    :..|||         .|.||:..|.:.:.::     :.::||.    |.....
Mouse   889 SCFSFLRF----IDVSPA---------EMANLMLQGLLARWLA-----LFLSLKA----SYRLHQ 931

  Fly  1399 SSSTTASSPTGALSVLSNSK-LLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTL 1462
            ..|......|...|.|.|.. |||....::.|                                 
Mouse   932 LRSWAEPDGTSHQSYLRNKDFLLGVDFPLSFP--------------------------------- 963

  Fly  1463 TSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDL--ATHVKSTVQKQSIANGKTEPEEETEAE 1525
                                     .|...|::|.|  ::|.|:       .:|.::        
Mouse   964 -------------------------NLCSCPLLKSLVFSSHCKA-------VSGYSD-------- 988

  Fly  1526 DPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGY 1590
                                   .::::||:                   ||.||:         
Mouse   989 -----------------------HVVHQRRS-------------------ATSSLR--------- 1002

  Fly  1591 ANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQR 1655
              ||          |...|.||             ..:..|.|.|..:..|..:.|:   ::|: 
Mouse  1003 --CC----------LLTELPSF-------------LCVASPRVTAVPLDSYCNDRSA---EYER- 1038

  Fly  1656 IENIVDQ--ALRPKLALLHPI-------ISEMTTKFPDP----------------------RLIQ 1689
              .::.:  :|..|..||:..       :|..:..||:|                      .||.
Mouse  1039 --GVLKEGGSLAAKQCLLNGAPELATDWLSRRSQFFPEPAGGLLSIRPQNGWSFIRIPGKESLIT 1101

  Fly  1690 YDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMER 1754
             |.|||..:|.||.:||..||||||::|||:|:|:||.::.|..|.|:|||||:::.:|:.::..
Mouse  1102 -DSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVAD 1165

  Fly  1755 FNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSE 1819
            |.....||.|:||||:||:|||||.||||||||||||||:|.||.||.||:|||:.|.:|||:.:
Mouse  1166 FQTRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICK 1230

  Fly  1820 RTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLF-------------TMEQSEQDESS 1871
            .|||..||::|.:|..:..|.|.||||.....|...:..|.             ..|:.:|:||:
Mouse  1231 GTIEERILQRAKEKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEELEKKLRLRQEEKRQQEESN 1295

  Fly  1872 QEKSENKDR 1880
            :.|...:.|
Mouse  1296 RVKERKRKR 1304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
domNP_001286676.1 HSA 543..614 CDD:214727 15/77 (19%)
HepA 692..>1235 CDD:440319 187/573 (33%)
DEXQc_SRCAP 949..1171 CDD:350761 115/227 (51%)
SF2_C_SNF 1685..1817 CDD:350180 76/153 (50%)
DISARM_DrmD_b <1702..>1936 CDD:468472 89/192 (46%)
HEC1 <1858..>2031 CDD:444066 7/36 (19%)
SP1-4_N 2486..>2819 CDD:425404
Ino80NP_080850.2 Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D. /evidence=ECO:0000250|UniProtKB:Q9ULG1 1..268 51/238 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 46..88 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..250 12/47 (26%)
Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1. /evidence=ECO:0000250|UniProtKB:Q9ULG1 214..528 76/402 (19%)
HepA 300..>832 CDD:440319 196/603 (33%)
DEXQc_INO80 520..748 CDD:350760 115/227 (51%)
Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2. /evidence=ECO:0000250|UniProtKB:Q9ULG1 523..1559 303/997 (30%)
SF2_C_SNF 1093..1228 CDD:350180 75/135 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1285..1319 6/20 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1391..1464
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1504..1559
Blue background indicates that the domain is not in the aligned region.

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