Protein Alignment dom and HLTF

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: XP_011511393.1
• Gene: HLTF / 6596
• HGNCID: 11099
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 1331
• Identity: 249/1331 - (18%)
• Similarity: 423/1331 - (31%)
• Gaps: 539/1331 - (40%)

  Fly   644 KQALDQHLSFIVDQTEKFSQQLVEGM-----------------------NKSVADTPSLNSSRL- 684
            |:.|...|::|:|  .|.:|  :||:                       .|:|:|....:..:|
Human   112 KKELAGALAYIMD--NKLAQ--IEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLG 172

  Fly   685 TSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRD 749
            .:||...   |..|||.....    .....:..|...|....::.:.:||....|     |:..|
Human   173 PAPKTLG---FNLESGWGSGR----AGPSYSMPVHAAVQMTTEQLKTEFDKLFED-----LKEDD 225

  Fly   750 KLMKEEQSSAIKTETP---------------DDSDDSEFEAKEASDDDENTISKQEEAEQEIDHK 799
            |..:.|.:.||  |||               ::|.:.....::.:|...|||:...|.::..:..
Human   226 KTHEMEPAEAI--ETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVH 288

  Fly   800 KEI--DELEADNDL-SVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAV--DSTEESEDAA 859
            ..|  |::.....| ::..:|..:...:|...:|.|......|.:.:|||..:  ::|.|..|..
Human   289 GGILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGL 353

  Fly   860 TEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAES 924
            ::|....|...:.:|::|        ||....::.:|.......||.......|        :|.
Human   354 SKDASRCSEQPSISDIKE--------KSKFRMSELSSSRPKRRKTAVQYIESSD--------SEE 402

  Fly   925 LQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLA 989
            ::           .:.:|..:|..|:..|          :|.|...    :.|..|.|:.:|...
Human   403 IE-----------TSELPQKMKGKLKNVQ----------SETKGRA----KAGSSKVIEDVAFAC 442

  Fly   990 HL---------------ACA-KGNWGPH--------LIVVPSSVMLNWEMEFKKWCPG---FKIL 1027
            .|               ||| :|:....        ||:.|.||:.||..:|.:....   ....
Human   443 ALTSSVPTTKKKMLKKGACAVEGSKKTDVEERPRTTLIICPLSVLSNWIDQFGQHIKSDVHLNFY 507

  Fly  1028 TYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQD-----QQSFRRKKWKYLILDEAQNIKNFKS 1087
            .|||..:.|:...:  :|.:   :.:|:|.::..|     .......:|..:||||...|:|..:
Human   508 VYYGPDRIREPALL--SKQD---IVLTTYNILTHDYGTKGDSPLHSIRWLRVILDEGHAIRNPNA 567

  Fly  1088 QRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHF--LMPYVFSSHREFKEWF----SNPMTGMI 1146
            |:.:.:|:..:|||.:|||||:||.|.:||||:.|  |.|::      .:||:    ..|:|...
Human   568 QQTKAVLDLESERRWVLTGTPIQNSLKDLWSLLSFLKLKPFI------DREWWHRTIQRPVTMGD 626

  Fly  1147 EGNMEYNETLITRLHKVIRPFLLRRLKKEVEK-----QMPKKYEHVITCRLSNRQRYLYEDFMS- 1205
            ||.:.       ||..:|:...|||.|....|     ::|::...:....||:.:|.:|:...:
Human   627 EGGLR-------RLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQHITLSDEERKIYQSVKNE 684

  Fly  1206 -RAKTRETLQTGNLLS----VINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIME 1265
             ||........|.:|:    |:.:|::||::|.|..:.
Human   685 GRATIGRYFNEGTVLAHYADVLGLLLRLRQICCHTYLL--------------------------- 722

  Fly  1266 YDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRV 1330
                                                                             
Human   723 ----------------------------------------------------------------- 722

  Fly  1331 RSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVV 1395
                      .|||
Human   723 ----------TNAV--------------------------------------------------- 726

  Fly  1396 TTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARL 1460
              :|:..:|.|       |.|.            ||.::.|.:                ....:|
Human   727 --SSNGPSAFS-------LGND------------TPEELRKKL----------------IRKMKL 754

  Fly  1461 TLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAE 1525
            .|:|.:....:......||             |::...| ||
Human   755 ILSSGSDEECAICLDSLTV-------------PVITHCA-HV----------------------- 782

  Fly  1526 DPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGY 1590
                                                   .|:..|.:.:|          ..:.:
Human   783 ---------------------------------------FCKPCICQVIQ----------NEQPH 798

  Fly  1591 ANC--CTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAP-RIRRYVQNLSSTHWQH 1652
            |.|  |     ||....::||:                       |.| .:.|..:..|...|..
Human   799 AKCPLC-----RNDIHEDNLLE-----------------------CPPEELARDSEKKSDMEWTS 835

  Fly  1653 EQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQ 1717
            ..:|.           ||:| .::::..|.|:                         .:.|:.:|
Human   836 SSKIN-----------ALMH-ALTDLRKKNPN-------------------------IKSLVVSQ 863

  Fly  1718 MTKMLDVLEAFLNYHGHIYLRLDGS----TRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLT 1778
            .|..|.::|..|...|.::.|||||    .|||..|.......|...|  .:||.::||||:||:
Human   864 FTTFLSLIEIPLKASGFVFTRLDGSMAQKKRVESIQCFQNTEAGSPTI--MLLSLKAGGVGLNLS 926

  Fly  1779 GADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEG 1843
            .|..|...|..|||..:.|..|||||:||.::|.|.:.:.:.::|.|:||..|:||.|:     .
Human   927 AASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLKIQNKKRELA-----A 986

  Fly  1844 GNFTTTYFKSSTIKDLFTMEQSEQDESSQEK 1874
            |.|.|              ::...||..|.|
Human   987 GAFGT--------------KKPNADEMKQAK 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727
		HepA	692..>1235	CDD:440319	135/611 (22%)
		DEXQc_SRCAP	949..1171	CDD:350761	66/259 (25%)
		SF2_C_SNF	1685..1817	CDD:350180	42/135 (31%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	57/177 (32%)
		HEC1	<1858..>2031	CDD:444066	4/17 (24%)
		SP1-4_N	2486..>2819	CDD:425404
HLTF	XP_011511393.1	HIRAN	60..153	CDD:400928	9/44 (20%)
		DEXHc_HLTF1_SMARC3	240..644	CDD:350829	99/462 (21%)
		DEAD-like_helicase_N	283..>357	CDD:475120	14/73 (19%)
		HepA	<472..990	CDD:440319	164/883 (19%)
		RING-HC_HLTF	759..813	CDD:438172	14/144 (10%)