|
Fly 86 LPVPLSPLPQQQQ-----QTAEATAAAAAPAHSNVSVSSSTIEASVLPPQAKRQRLDDNEDRTSA 145
||..|..|.|..| ....::|:...|.....:.:..:.|::...|:: :..::..|..
Human 39 LPSSLDSLDQMNQDGGGGDVGNSSASELVPPPEETAPTELSKESTAPAPES----ITLHDYTTQP 99
Fly 146 ASIVGPA----ESSNIVSSLLPASVASSSEV-------GGLSSTALQDLNALKKRILQQKLQILR 199
||...|| ::|...|.|| .|:.|.|: .|:|:||:...:|
Human 100 ASQEQPAQPVLQTSTPTSGLL--QVSKSQEILSQGNPFMGVSATAVSSSSA-------------- 148
Fly 200 NLKERHLENVSEYFYLQNGGSMMDYPAWRKKTPTPQFISYSNANRIDQLIHEDKPSTSAAAA-AA 263
||. .|| :|.:| :|.:..||:|...| .|
Human 149 ------------------GGQ------------PPQ-----SAPKI--VILKAPPSSSVTGAHVA 176
Fly 264 QNQKYTTQQTDSVESSLVSGIGTGA----TK---GAPLDGNISNSTVKTNTQSQVPSKIGSFTES 321
|.| .|...|....||:|...|. || |.||...:|..:..|...::||....:....
Human 177 QIQ---AQGITSTAQPLVAGTANGGKVTFTKVLTGTPLRPGVSIVSGNTVLAAKVPGNQAAVQRI 238
Fly 322 TPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAVEAEIKIPAV--GATPVAISTKLPAAV 384
...:.........| ..|:| .:||..|....:| ||| .:||....:|....|
Human 239 VQPSRPVKQLVLQP---VKGSA---------PAGNPGATGPPLK-PAVTLTSTPTQGESKRITLV 290
Fly 385 VQLTQQGHIPGRPLGGRHGMVFGQIPAPPAAVGNPSVPLVPG----GTP---------------- 429
:|..|. |.|.|.|| :|.|.:|......||....|... |.|
Human 291 LQQPQS----GGPQGHRH-VVLGSLPGKIVLQGNQLAALTQAKNAQGQPAKVVTIQLQVQQPQQK 350
Fly 430 --LLPCNTSAGSTALRRPQGQNNASSGSAAAS--------GGG---GSLTPTPLYTGNGPAA--- 478
::|...|: :||.|...|:.....| |.| |.....|:.....|.|
Human 351 IQIVPQPPSS------QPQPQQPPSTQPVTLSSVQQAQIMGPGQSPGQRLSVPVKVVLQPQAGSS 409
Fly 479 LGGSGGLTPGTPTSGS----LLSPA-----LGGGSGTPNSAAQEFSFK-AKQEVYVMQRISELQR 533
.|.|.||:.....|.| |.||| .||.:|...:...|...| .|....|.:.|:..:.
Human 410 QGASSGLSVVKVLSASEVAALSSPASSAPHSGGKTGMEENRRLEHQKKQEKANRIVAEAIARARA 474
Fly 534 EGLWTERRLPK-LQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATA 597
.| |:.:|: |.|...|....: || .::::.||:|.::..: :|..:.|.:.
Human 475 RG---EQNIPRVLNEDELPSVRPE---EE--------GEKKRRKKSAGERLKE--EKPKKSKTSG 523
Fly 598 AQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFS 662
|.:.: .:.:|..:...:.::.|...|:....||........|..:.::.:..|....:.:|::
Human 524 ASKTK--GKSKLNTITPVVGKKRKRNTSSDNSDVEVMPAQSPREDEESSIQKRRSNRQVKRKKYT 586
Fly 663 QQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAK--------AEEDAADVK 719
|.::..:.|........:|.|.: .:...||...|.|.||:.. :|||||.|.
Human 587 ----EDLDIKITDDEEEEEVDVTGPIK--PEPILPEPVQEPDGETLPSMQFFVENPSEEDAAIVD 645
Fly 720 EEVTALAKESEMDFDDFLNDLPPG-YLENRDKLMKEEQSSAIKTETPDDSDDSE----------F 773
:.::....:.| ||.| |.|..:..:|.:..|.:..|....|...: |
Human 646 KVLSMRIVKKE---------LPSGQYTEAEEFFVKYKNYSYLHCEWATISQLEKDKRIHQKLKRF 701
Fly 774 EAKEAS------DDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRK 832
:.|.|. :|:|.......|.::.:|....||: ||...|...|.|:.|
Human 702 KTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSIDK---DNGEPVIYYLVKWCS---------- 753
Fly 833 LAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSG 897
.| .||:..|.:||:...|. .:.:....:...||.:
Human 754 -LP-------------------YEDSTWELKEDVDEGKI-REFKRIQSRHPELKRV--------- 788
Fly 898 AAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVT 962
.....::..|.::.:: :..::.|||||..|::||:.
Human 789 ----NRPQASAWKKLELSHE-------------------------YKNRNQLREYQLEGVNWLLF 824
Fly 963 MNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKIL 1027
....:.|.|||||||||||||:||.|..:... |..||.|::.|.|.:.|||.||..|.. ...:
Human 825 NWYNRQNCILADEMGLGKTIQSIAFLQEVYNV-GIHGPFLVIAPLSTITNWEREFNTWTE-MNTI 887
Fly 1028 TYYGSQKERKLKRV---------GWTKPNA--FHVCITSYKLVVQDQQSFRRKKWKYLILDEAQN 1081
.|:||...|::.:. |...|.| |...||::::::.|....|..:|:.:|:|||..
Human 888 VYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHR 952
Fly 1082 IKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMI 1146
:||...:....|.:...|.::|||||||||.:.||:||:|||.|..|.|..||.:.|.:..|
Human 953 LKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT--- 1014
Fly 1147 EGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRE 1211
|..:.:|..:::|.:|||||::|||.:..|.|.:|...|:|.|:..|...:. |...
Human 1015 -------EEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILE--KNFS 1070
Fly 1212 TLQTG----NLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQI 1272
.|..| |:.:::|.:|:|||.||||
Human 1071 FLSKGAGHTNMPNLLNTMMELRKCCNHP------------------------------------- 1098
Fly 1273 NLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQ 1337
Human 1099 ----------------------------------------------------------------- 1098
Fly 1338 RIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSST 1402
Human 1099 ----------------------------------------------------------------- 1098
Fly 1403 TASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTT 1467
||
Human 1099 -------------------------------------------YL-------------------- 1100
Fly 1468 ASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQE 1532
.||..|
Human 1101 --------------------------------------------INGAEE--------------- 1106
Fly 1533 LIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAM 1597
Human 1107 ----------------------------------------------------------------- 1106
Fly 1598 AHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQ 1662
.:|..|.|.|. .:| |:..::.:|..
Human 1107 ---------KILTEFREACH-----------IIP--------------------HDFHLQAMVRS 1131
Fly 1663 ALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEA 1727
| |||..:|:||.:||..||:||||:||.:.||:||.
Human 1132 A-----------------------------GKLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILED 1167
Fly 1728 FLNYHGHIYLRLDGSTRVEQRQILMERFN-GDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWN 1791
:|....::|.|:||..|...||..::||: .|...|.|:|.||:||:|||||.|||.|.:|||||
Human 1168 YLIQRRYLYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWN 1232
Fly 1792 PTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKAN-----QKRMLSDMAIEGGNFT-TTY 1850
|..|.|||.|||||||::.|.:|||::..:.|..:..||: .|.:|..|:...||.| ...
Human 1233 PQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDGNITGIQQ 1297
Fly 1851 FKSSTIKDL-----FTMEQSEQDESSQEKSENKDRIV--ATTTLSDTPSTVVETEKQSLRAFEHA 1908
|....|:|| :.....|.||.|:...|:.|:|: .|||:: :|:|.:.....:.:
Human 1298 FSKKEIEDLLRKGAYAAIMEEDDEGSKFCEEDIDQILLRRTTTIT------IESEGKGSTFAKAS 1356
Fly 1909 LAAAEDEQDVQATKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVELSKADLEM------QNLV 1967
..|:|:..| |:.:|||.. |....||||:| .|||
Human 1357 FVASENRTD-----------------------ISLDDPNFW---QKWAKKADLDMDLLNSKNNLV 1395
Fly 1968 KQLSPIERYAMRFVEETGAAWTAEQLRAAE-AELEAQKREWEANRLAAMHK---EEELLKQETEA 2028
.....:.:....|. |.:.....| ::||::..|...:|....|. ..:..:.|
Human 1396 IDTPRVRKQTRHFS-------TLKDDDLVEFSDLESEDDERPRSRRHDRHHAYGRTDCFRVE--- 1450
Fly 2029 EEMLTYS---RKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYSLSFMYELEPIAETDLP 2090
:.:|.|. .:|..:.....|...|: ::|.|....|
Human 1451 KHLLVYGWGRWRDILSHGRFKRRMTER---------------------------DVETICRAIL- 1487
Fly 2091 PVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPN 2155
||....::......|: ::|..:|......:|| |...|. :
Human 1488 -VYCLLHYRGDENIKGF--------------------IWDLISPAENGKTKEL--QNHSGL---S 1526
Fly 2156 MPIP-GLKPQLPTKPLTEPEAMAEW-------CVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNW 2212
:|:| |.|.:......|.....|:| .:|:|.:....|.: .|:.:||
Human 1527 IPVPRGRKGKKVKSQSTFDIHKADWIRKYNPDTLFQDESYKKHLKH----QCNKVLL-------- 1579
Fly 2213 DLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTLRTE---------YLK 2268
:.|..|.. |:| |...:.:|.|...:.:| .|:
Human 1580 ------------------RVRMLYYL----RQE---VIGDQAEKVLGGAIASEIDIWFPVVDQLE 1619
Fly 2269 SPLRYL-----RTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVL 2328
.|..:. ::..:.|..:....|.|||: .....:|:||..|..:..| .:| .||
Human 1620 VPTTWWDSEADKSLLIGVFKHGYEKYNTMRA---DPALCFLEKAGRPDDKAIA-----AEH-RVL 1675
Fly 2329 QEFGIL----NYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPA--- 2386
..|..: ::|:.........::.....:...|..:......:.|:. ..::|..|||.
Human 1676 DNFSDIVEGVDFDKDCEDPEYKPLQGPPKDQDDEGDPLMMMDEEISVID--GDEAQVTQQPGHLF 1738
Fly 2387 -PPPLPQQQQPQQVVQQVQQQQQQQQ---------------------------QQQQQQVVQQQL 2423
||......:.:::|...|:..:::| :::||:..:::.
Human 1739 WPPGSALTARLRRLVTAYQRSYKREQMKIEAAERGDRRRRRCEAAFKLKEIARREKQQRWTRREQ 1803
Fly 2424 PTVSNVQQTLPVQQTVELVQQQPTTTTTVA---------------------------VPAAGGQL 2461
.....|..|..|:...:.:|.......|.| .||||.:.
Human 1804 TDFYRVVSTFGVEYDPDTMQFHWDRFRTFARLDKKTDESLTKYFHGFVAMCRQVCRLPPAAGDEP 1868
Fly 2462 --QQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHP----------------------------- 2495
..|.|:.:|....|.......||.:.::|:..||
Human 1869 PDPNLFIEPITEERASRTLYRIELLRRLREQVLCHPLLEDRLALCQPPGPELPKWWEPVRHDGEL 1933
Fly 2496 --GQGGQSNTQQLVKTIVGTSSSLTAGQLQQLAQQSAVASGGQSSVSVVLTTPVQTLPSVVQPQI 2558
|......:|.....:.....|..|.::..:....|.| |..:|.....|.:
Human 1934 LRGAARHGVSQTDCNIMQDPDFSFLAARMNYMQNHQAGA-------------PAPSLSRCSTPLL 1985
Fly 2559 GSGAQIVSISSQTL------PVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQ 2617
.. |..|.::..| ||..||: ::..||.|:.:|...........::|..|..
Human 1986 HQ--QYTSRTASPLPLRPDAPVEKSPE-------ETATQVPSLESLTLKLEHEVVARSRPTPQDY 2041
Fly 2618 TTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQ------TQLRLA 2676
...|:..:|| |.:.:...|.:.: ::|.|:
Human 2042 EMRVSPSDTT------------------------------PLVSRSVPPVKLEDEDDSDSELDLS 2076
Fly 2677 AVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPSG 2741
.:..|.::.::...::.....|..::..| :|.|| ..:||.:.||..|..:....|
Human 2077 KLSPSSSSSSSSSSSSSSTDESEDEKEEK-----LTDQS---RSKLYDEESLLSLTMSQDGFP-- 2131
Fly 2742 SAGATGATANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTVQAGNVVSSVQMHGQARTQFI 2806
:......|..|: ::|....|:.....:|.::.:......|.:|...|| .|:|
Human 2132 NEDGEQMTPELL-----LLQERQRASEWPKDRVLINRIDLVCQAVLSGKWPSS------RRSQ-- 2183
Fly 2807 KQMAAGKQQLQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQASGALFTTTTGQQQQQQQQQ 2871
:|..|........:....:.|....||..:....:..||..|::.:.|: :|...|..:.::
Human 2184 -EMVTGGILGPGNHLLDSPSLTPGEYGDSPVPTPRSSSAASMAEEEASAV---STAAAQFTKLRR 2244
Fly 2872 GQLPVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSATNPTVQAGSV---NMTLPQLKP 2933
| :.:.:....:| :..|:.::.....:.|..| ...|...|.
Human 2245 G----------MDEKEFTVQIK------------DEEGLKLTFQKHKLMANGVMGDGHPLFHKKK 2287
Fly 2934 GS-----QIKVTMPNQMRHLQMQQQLTMP--RKISRMTQLVSASGQPTATNIITTTGPQQQQQGV 2991
|: :::|....:..||.:..:..:| .|:. .|.::....|::.:..:
Human 2288 GNRKKLVELEVECMEEPNHLDVDLETRIPVINKVD-------------GTLLVGEDAPRRAELEM 2339
Fly 2992 TVSGGGTLPTVA--------SQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLSNSVTMQQIQQV-M 3047
.:.|. |..| .:.:::|..|:.. :|.|...|.:.|:.:|.. .
Human 2340 WLQGH---PEFAVDPRFLAYMEDRRKQKWQRCK------------KNNKAELNCLGMEPVQTANS 2389
Fly 3048 RSGQQGTLATTNLVLGKTSVGRVIPVSVASQANQRQTIQVVSAASAQALAAGNLRTHVAGPSIAS 3112
|:|::|... :|...||:|..:|.:::::: |..:| |.::.
Human 2390 RNGKKGHHT-------ETVFNRVLPGPIAPESSKKR--------------ARRMR-----PDLSK 2428
Fly 3113 TLKVAAPGSAGGQTTQQTL---------IAALQHNQRQNASPVRLQTTAGG-------NLLAVVQ 3161
.:.:...||.|..:...|. :::|.|:...:||...:....|| :...::.
Human 2429 MMALMQGGSTGSLSLHNTFQHSSSGLQSVSSLGHSSATSASLPFMPFVMGGAPSSPHVDSSTMLH 2493
Fly 3162 --------QQQQQQHTSIAGPTAGPAEVMTITQTTTTLPTVGSLQQQQQQQQQQGGISQ 3212
......|..:..|....:.|.|.:.||..||.:...:...:.::....:||
Human 2494 HHHHHPHPHHHHHHHPGLRAPGYPSSPVTTASGTTLRLPPLQPEEDDDEDEEDDDDLSQ 2552
| 
