|
Fly 7 AGGGH------EGLSPAPPAVPDRVTPHSTEISVAPANSTSTTVRAAGSV------------GAA 53
:.||| .||:........::....|.|:|.....:....::.|:: ||.
Human 185 SSGGHFVFQDGSGLTQIAQGAQVQLQHPGTPITVRERRPSQPHTQSGGTIHHLGPQSPAAAGGAG 249
Fly 54 LPATRHHQHIAT-----QVKGIASSSSKQQKQ-LASAQLPVPLSPLPQQQQQTAEATAAAAAPAH 112
|.......||.| |:..|......||:| |....||.||. .|.|.....|..
Human 250 LQPLASPSHITTANLPPQISSIIQGQLVQQQQVLQGPPLPRPLG---------FERTPGVLLPGA 305
Fly 113 SNVSVSSSTIEASVLPPQAKRQRLDDNEDRTSAASIVGPAESSNIVSSLLPASVASSSEVGGLSS 177
...:....| |..|| .:..||: |.|. :|||...||.:: |:..
Human 306 GGAAGFGMT---SPPPP--------TSPSRTA----VPPG-----LSSLPLTSVGNT----GMKK 346
Fly 178 T---------ALQDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQN-GGSMMDYPAWRKKTP 232
. |..::..::|:.|....|.::.|||...|.:.|.|:||: .|:|||:.|::||..
Human 347 VPKKLEEIPPASPEMAQMRKQCLDYHYQEMQALKEVFKEYLIELFFLQHFQGNMMDFLAFKKKHY 411
Fly 233 TPQFISYSNANRIDQLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGN 297
.| ..:|...|.:| |.|::.... ...:..:....:..::..|||:|.|
Human 412 AP-LQAYLRQNDLD--IEEEEEEEE---EEEEKSEVINDEQQALAGSLVAGAG------------ 458
Fly 298 ISNSTVKTN---TQSQVPSKIGSFTESTPAATESNSSTTV---PG------------TATSGAAT 344
|||:|: .|..:|| .|...:|.....|......| || ||..|...
Human 459 ---STVETDLFKRQQAMPS-TGMAEQSKRPRLEVGHQGVVFQHPGADAGVPLQQLMPTAQGGMPP 519
Fly 345 STSATSAEASG-----------------NVLAVEAEI-----KIPAVGATPVAISTKLPAA---- 383
:..| |:.:| |..::...: ::|..|....|:|:.|..|
Human 520 TPQA--AQLAGQRQSQQQYDPSTGPPVQNAASLHTPLPQLPGRLPPAGVPTAALSSALQFAQQPQ 582
Fly 384 VVQL---------TQQGHIPGRPLGGRHGMVFGQIPAPPAA---------------VGNP----- 419
||:. |||.::| |||||:: |..|
Human 583 VVEAQTQLQIPVKTQQPNVP--------------IPAPPSSQLPIPPSQPAQLALHVPTPGKVQV 633
Fly 420 ------SVPLVPGGT-----PLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTG 473
|:|.:...| |..|| .||...::.|| .|..||.|...:|......
Human 634 QASQLSSLPQMVASTRLPVDPAPPC---------PRPLPTSSTSS-LAPVSGSGPGPSPARSSPV 688
Fly 474 NGPA-----ALGGSGGLTPG----TPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRIS 529
|.|: ||......||| .||... |||....| :.:|:....:.:...|..|.|||:
Human 689 NRPSSATNKALSPVTSRTPGVVASAPTKPQ--SPAQNATS-SQDSSQDTLTEQITLENQVHQRIA 750
Fly 530 ELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDK 594
||::.|||::||||||||..|||:|||||||||.|:|.||||||:||..||||..:.|.::.::|
Human 751 ELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEK 815
Fly 595 ATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTE 659
....:|.:|.::.:|:|:|:..|||::.||||:|::||.|.:.::|||||:||: .:
Human 816 QLREERGKKEEQSRLRRIAASTAREIECFWSNIEQVVEIKLRVELEEKRKKALN---------LQ 871
Fly 660 KFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTA 724
|.|:: ..:.||:......|.::
Human 872 KVSRR---------------------------GKELRPKGFDALQESSL---------------- 893
Fly 725 LAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQ 789
|..|...:..|..:.|.|: .||:|.||.::
Human 894 ------------------------DSGMSGRKRKASISLTDDE-----------VDDEEETIEEE 923
Fly 790 EEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEE 854
|..|..:||:.|:..|..:.:|.:..|:..|:....||.: .|| |:.|.:|.| ..|:
Human 924 EANEGVVDHQTELSNLAKEAELPLLDLMKLYEGAFLPSSQ----WPR-PKPDGEDTS----GEED 979
Fly 855 SEDAA--TEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLND 917
::|.. .|..:||..:.:...|:: ..|......|....|| :.|
Human 980 ADDCPGDRESRKDLVLIDSLFIMDQ-------------------FKAAERMNIGKPNAKD--IAD 1023
Fly 918 AAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTI 982
..|:||::.|||:...:|:|....|.||..:||:||.||||||..:..:.||||||||.|||||:
Human 1024 VTAVAEAILPKGSARVTTSVKFNAPSLLYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTV 1088
Fly 983 QTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPN 1047
|.||..|||||.:|||||||:||.|..:|.||:|.|:||||.|||:|.||.:|.|.||..|.:||
Human 1089 QIIAFFAHLACNEGNWGPHLVVVRSCNILKWELELKRWCPGLKILSYIGSHRELKAKRQEWAEPN 1153
Fly 1048 AFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQND 1112
:||||||||....:...:|.|.:||.|::||.|.:|....:.|:.:....:::||||..:||.|.
Human 1154 SFHVCITSYTQFFRGLTAFTRVRWKCLVIDEMQRVKGMTERHWEAVFTLQSQQRLLLIDSPLHNT 1218
Fly 1113 LMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVE 1177
.:|||:::|||:|.: .:.:.|:|:....|.:.:|...::.|||:|.:||:|||.|::||
Human 1219 FLELWTMVHFLVPGI------SRPYLSSPLRAPSEESQDYYHKVVIRLHRVTQPFILRRTKRDVE 1277
Fly 1178 KQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARP 1242
||:.||||||:.|||||||:.||||.:.:..|:|.|::|:.::|:::|::|:::||||.:.|.|.
Human 1278 KQLTKKYEHVLKCRLSNRQKALYEDVILQPGTQEALKSGHFVNVLSILVRLQRICNHPGLVEPRH 1342
Fly 1243 TISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAP---PRK 1304
..|.:....:.:.:..|:...:|.|.:.:.:|...: |:.||..:| .|::.||:. |||
Human 1343 PGSSYVAGPLEYPSASLILKALERDFWKEADLSMFD--LIGLENKIT---RHEAELLSKKKIPRK 1402
Fly 1305 LIEDIDTAPLPAPR--------------------------------------------CPNGKYR 1325
|:|:|.|:..||.| .|.|..|
Human 1403 LMEEISTSAAPAARPAAAKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRTAAPTTASAAPQGPLR 1467
Fly 1326 --------------------FHIRVRSAELAQRIKLNAVKVGASPA----MRLE----------- 1355
|.....||...:....:|....|||| :|.:
Human 1468 GRPPIATFSANPEAKAAAAPFQTSQASASAPRHQPASASSTAASPAHPAKLRAQTTAQASTPGQP 1532
Fly 1356 -----------GSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSP-- 1407
|...:|.|.:|||....:..|..: |.|..:.:.|...:..:.|
Human 1533 PPQPQAPSHAAGQSALPQRLVLPSQAQARLPSGEV---------VKIAQLASITGPQSRVAQPET 1588
Fly 1408 ------TGALSVLSNSKLLGARSQINAPTPAKVAKTM-----QDGKPFFY----LTPATNSGAAG 1457
.|:...||:|:| .|:.|..|.::..:: ..|:|:.. :...|.|.|..
Human 1589 PVTLQFQGSKFTLSHSQL----RQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGA 1649
Fly 1458 ARLTLTSKTTA---SASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPE 1519
....|.||..| |.:..|.:..|..... |..||.....|..|.:...|....|
Human 1650 VHGALGSKPPAGGPSPAPLTPQVGVPGRVA----------VNALAVGEPGTASKPASPIGGPTQE 1704
Fly 1520 EETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRST 1584
|:| ::.||: |.::.::|.||....|:|| |:.::.| |..|..|..
Human 1705 EKT------------RLLKER----LDQIYLVNERRCSQAPVYG---RDLLRIC--ALPSHGRVQ 1748
Fly 1585 WQTRGYANCCTAMAHRNGWSLN--HLLKSFEE----------RCAD-LKPVFANFVIYVPSVCAP 1636
| || ::..|.|.... |...|..| ||.: |:.|.......:|.|.|.
Human 1749 W--RG------SLDGRRGKEAGPAHSYTSSSESPSELMLTLCRCGESLQDVIDRVAFVIPPVVAA 1805
Fly 1637 ----RIRRYVQNLSSTHWQHEQRIENIVDQALR----PKLALLHPIISEMTTKFPDPRLIQYDCG 1693
|:.| ....:.|..| |:.|.|| |....|....:....:||:.||:|:|.|
Human 1806 PPSLRVPR-----PPPLYSHRMR---ILRQGLREHAAPYFQQLRQTTAPRLLQFPELRLVQFDSG 1862
Fly 1694 KLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGD 1758
||:.:..||::||..|.||||.:||..|||:||.|||:|...|:|:|.:...||||.||..||.|
Human 1863 KLEALAILLQKLKSEGRRVLILSQMILMLDILEMFLNFHYLTYVRIDENASSEQRQELMRSFNRD 1927
Fly 1759 KRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIE 1823
:||||.||||.|...||||..||||:|||:|.||.|||:||:.|.|||:.:|:|||||||..:||
Human 1928 RRIFCAILSTHSRTTGINLVEADTVVFYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIE 1992
Fly 1824 VNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLS 1888
..:||... |.::.::|.:|.:::..:....||::||.:.....|.....|:|. ...||
Human 1993 EKLLKNGT-KDLIREVAAQGNDYSMAFLTQRTIQELFEVYSPMDDAGFPVKAEE------FVVLS 2050
Fly 1889 DTPSTVVETEKQSLRAFEHALAAAED-EQDVQATKTAKAEVAAD----LAEFDENIPIATEDPNA 1948
..||.......:..|.|..||.:.|. |:|.| |:|:..|... |:...||:| ..|:|:
Human 2051 QEPSVTETIAPKIARPFIEALKSIEYLEEDAQ--KSAQEGVLGPHTDALSSDSENMP-CDEEPS- 2111
Fly 1949 EGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQLRAAEAELEAQKREWEANRLA 2013
|:| |:.:.::||:|||:||:.::|....:...|:.|.:|..:....|.||...|.
Human 2112 ----QLE------ELADFMEQLTPIEKYALNYLELFHTSIEQEKERNSEDAVMTAVRAWEFWNLK 2166
Fly 2014 AMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNT---MEQMPMWCPPTPPQDNDNDIYIDYSL 2075
.:.:.|..|:.|.|..|:|||:|:|:.:..::..:. .|.||:|.||||||| |:|||:|..:
Human 2167 TLQEREARLRLEQEEAELLTYTREDAYSMEYVYEDVDGQTEVMPLWTPPTPPQD-DSDIYLDSVM 2230
Fly 2076 SFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQLARLR 2140
..|||..||.|..|||||||||.||.:||....| |..|.|..:..|||||||||.||.|.::|
Human 2231 CLMYEATPIPEAKLPPVYVRKERKRHKTDPSAAG--RKKKQRHGEAVVPPRSLFDRATPGLLKIR 2293
Fly 2141 RELKSQRFRGSFKPNMPIPGLKPQLPT--KPLTEP-EAMAEWCVFEDMAILHVLVNLQGLPCSLM 2202
||.|.|:.....|..:|. .|| ||| ||..|| :...||.:.||.|:|..:..|..||.:|.
Human 2294 REGKEQKKNILLKQQVPF--AKP-LPTFAKPTAEPGQDNPEWLISEDWALLQAVKQLLELPLNLT 2355
Fly 2203 LLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTLRTEYL 2267
::||..||||||||::||.||:.|||::|||.|||..|.||||| |.|..:|
Human 2356 IVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYENVIIPREEG-------KSKNNRP------- 2406
Fly 2268 KSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPKRQFSA-PSLMNPKHMEVLQEF 2331
|||:|:|..|.||:..:...|.||.:|....|::||.|..... |...||||..||.|.
Human 2407 ------LRTSQIYAQDENATHTQLYTSHFDLMKMTAGKRSPPIKPLLGMNPFQKNPKHASVLAES 2465
Fly 2332 GILNYDQPVSPQNIAAMKANKIREKQRG---QQMSQPPVGVGVVQQMQQQSQ---QQQQPAPPPL 2390
|| |||:|:.|..:|:::|.:|.::::. ||.:|.| .|.|....|.| ..||| ||||
Human 2466 GI-NYDKPLPPIQVASLRAERIAKEKKALADQQKAQQP---AVAQPPPPQPQPPPPPQQP-PPPL 2525
Fly 2391 PQQQ----QPQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQPTTTTT 2451
||.| ||......||.|.|.|.|.|.| |||.. .:.||..||.
Human 2526 PQPQAAGSQPPAGPPAVQPQPQPQPQTQPQ-----------------PVQAP---AKAQPAITTG 2570
Fly 2452 VAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSS 2516
.:.....|.:: ..:|.:::..|..:. ..||.|.:.
Human 2571 GSAAVLAGTIK----TSVTGTSMPTGAVSG--------------------------NVIVNTIAG 2605
Fly 2517 LTAGQLQQLAQQ--SAVASGGQSSVSVVLTTPVQTLPSVV---QP---QIGSGAQIVSISSQTLP 2573
:.|...|.:.:: |.||.| .||||..:.|:.| || .:|| |
Human 2606 VPAATFQSINKRLASPVAPG-------ALTTPGGSAPAQVVHTQPPPRAVGS------------P 2651
Fly 2574 VNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTLNTTMLRGQRIVSTA 2638
..::|.|.|:..||.:..|.||: .:||.|.|.|. |.|.
Human 2652 ATATPDLVSMATTQGVRAVTSVT---------------------ASAVVTTNLTP------VQTP 2689
Fly 2639 AGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQTTQLVTTKGIPVSALQQG 2703
|.:.:.|.:.|.| |.:| |:..:|:.||. || ..|..| ||
Human 2690 ARSLVPQVSQATG---VQLP--GKTITPAHFQL-LR--------QQQQQQ------------QQ- 2727
Fly 2704 GKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQA---VP--SGSAGATGATANLVQAGGTIIQAS 2763
.||......|..:|:..:..||||.: || .|.|.:... ::|.|.:
Human 2728 --------QQQQQQQQQQQQQQQQQQQQQTTTTSQVQVPQIQGQAQSPAQ----IKAVGKL---- 2776
Fly 2764 NMATHVTSQKVAVSGMPGTSTTVQAGNVVSSVQMHGQARTQFIKQMAAGKQQLQRQVVSADGTTT 2828
...|:...:.....||......||.:... |...|...|.:...||...|: ||
Human 2777 -TPEHLIKMQKQKLQMPPQPPPPQAQSAPP------QPTAQVQVQTSQPPQQQSPQL------TT 2828
Fly 2829 TTAAGDMLLVKRHNILAAQKAQQASGALFTTTTGQQQQQQQQQGQLPVAGQPQQVTQHQIASLVK 2893
.||.....|:....:...|.|: |....|.|.|.|.|.|.|.| ||.||. :|....
Human 2829 VTAPRPGALLTGTTVANLQVAR-----LTRVPTSQLQAQGQMQTQAP---QPAQVA---LAKPPV 2882
Fly 2894 ASTAAAASGSSVNAGGVTVSATNPTVQAG-SVNMTLPQLKPGSQIKVTMPNQMRH-LQMQQQLTM 2956
.|..||. |::.||| |.|...|| ||.:..|| |...|..|..|..|:. |:::||...
Human 2883 VSVPAAV----VSSPGVT---TLPMNVAGISVAIGQPQ-KAAGQTVVAQPVHMQQLLKLKQQAVQ 2939
Fly 2957 PRKI--SRMTQLVSASGQPTATNIITTTGPQQQQQGVTVSGGGT--LPTVASQQQQQQHQQKVGG 3017
.:|. .:..|..:|..|......|||.|.||:..........| |.|..|| .||:.|
Human 2940 QQKAIQPQAAQGPAAVQQKITAQQITTPGAQQKVAYAAQPALKTQFLTTPISQ------AQKLAG 2998
Fly 3018 GNSVQAQLLHIQNTKGLSNSVTMQQIQQVMRSGQQG---TLATTNLVLGKTSVGRVIPVSVASQA 3079
...||.|:...:..:.:.....:..||||..:.||. |:|.|........|..:..|:..:|.
Human 2999 AQQVQTQIQVAKLPQVVQQQTPVASIQQVASASQQASPQTVALTQATAAGQQVQMIPAVTATAQV 3063
Fly 3080 NQRQTI--QVVSAASAQALAAGNLRTHVAGPSIASTLKVAAPGSAGGQTTQQTLIAALQHNQRQN 3142
.|::.| |||:.|||.....| .|:.|. .|.|:...:.|..| :..
Human 3064 VQQKLIQQQVVTTASAPLQTPG-------APNPAQ-----VPASSDSPSQQPKL--------QMR 3108
Fly 3143 ASPVRLQT 3150
...|||:|
Human 3109 VPAVRLKT 3116
| 
