DRSC/TRiP Functional Genomics Resources

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Protein Alignment dom and SMARCAD1

DIOPT Version :10

Sequence 1:NP_001286676.1 Gene:dom / 45655 FlyBaseID:FBgn0020306 Length:3233 Species:Drosophila melanogaster
Sequence 2:NP_001121901.1 Gene:SMARCAD1 / 56916 HGNCID:18398 Length:1028 Species:Homo sapiens


Alignment Length:1366 Identity:314/1366 - (22%)
Similarity:484/1366 - (35%) Gaps:535/1366 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   583 CAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAR-----EVKSFWSNVEKLVEYKHQTKIEEK 642
            |:..||:...:|.|....:|.:::.:.:.:.:...|     |::.. |.:|.|.:.|.|| ::|.
Human   106 CSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDL-SELEDLKDAKLQT-LKEL 168

  Fly   643 RKQALDQHLSFIVDQT-----------------------EKFSQQLVEGMNKSVADTPSLNSSRL 684
            ..|..|..|..:::.|                       .|.|............|..|:..:||
Human   169 FPQRSDNDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRL 233

  Fly   685 TSPKRESDDDFRPESGSEDDEETIAKAEEDAADV-KEEVTALAKESEMDFDDFLNDLPPGYLENR 748
            ...: ||::.....|..|..|..:.|.:::..:. |:|:..:.||.|..:.:.|..|        
Human   234 DHGE-ESNESAESSSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESL-------- 289

  Fly   749 DKLMKEEQSS--AIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDL 811
             |:..|:|..  ..::|.|:        .||.|...:|......:.:     .|:...::|.|..
Human   290 -KVFAEDQDMQYVSQSEVPN--------GKEVSSRSQNYPKNATKTK-----LKQKFSMKAQNGF 340

  Fly   812 SVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDD-STAVDSTEESEDAATEDE------------ 863
            :      |.:.:...:|||   ...|.|.||..| .:::|....|.:...||.            
Human   341 N------KKRKKNVFNPKR---VVEDSEYDSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDA 396

  Fly   864 --EDLSTVKTDTDMEEQDEQE----DGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALA 922
              .:|:.:...:..:.|...|    :..::|......|:|.:            :|::.....|.
Human   397 SIGELTLIPQCSQKKAQKITELRPFNSWEALFTKMSKTNGLS------------EDLIWHCKTLI 449

  Fly   923 ES------LQPKGNTLSS--TNVVTPV-----------PFLLKH--SLREYQHIGLDWLVTMNER 966
            :.      |..|...:|:  |..||.:           |.:|..  ||:.||.:||:||..:::.
Human   450 QERDVVIRLMNKCEDISNKLTKQVTMLTGNGGGWNIEQPSILNQSLSLKPYQKVGLNWLALVHKH 514

  Fly   967 KLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYG 1031
            .||||||||||||||||.||.||:| ..:||.||||||||:|.:.||..|...|||..|:|.|||
Human   515 GLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCYYG 578

  Fly  1032 SQKERKLKRVG-WTKPNAFHVCITSYKLVV---QDQQSFRRKKWKYLILDEAQNIKNFKSQRWQL 1092
            ||:|||..|.. .::...::|.:|:|...:   .|:..|||.|..|.|.||...:||..|.|:|.
Human   579 SQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQH 643

  Fly  1093 LLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSH-REFKEWFSNPMTGMIEGNMEYNETL 1156
            |:..:...||||||||:||:|:||.||::|:||::|||. .|.:..||:......|.:: |.:..
Human   644 LMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSI-YEKER 707

  Fly  1157 ITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSR-AKTRETLQTGNLLS 1220
            |....::|:||:|||:|:||.||:|.|.:.:..|.:|.:|..||....:| .|:...|.|.....
Human   708 IAHAKQIIKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGLFNRLKKSINNLVTEKNTE 772

  Fly  1221 VINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLE 1285
            :.||:|||||:.|||                                             |||.:
Human   773 MCNVMMQLRKMANHP---------------------------------------------LLHRQ 792

  Fly  1286 QTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASP 1350
            .    |.:.|.:                                    |::|.:........|:|
Human   793 Y----YTAEKLK------------------------------------EMSQLMLKEPTHCEANP 817

  Fly  1351 AMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLS 1415
            .:..|..::|                                                       
Human   818 DLIFEDMEVM------------------------------------------------------- 827

  Fly  1416 NSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVT 1480
                                                                             
Human   828 ----------------------------------------------------------------- 827

  Fly  1481 ASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAAL 1545
                           .|...||                                           
Human   828 ---------------TDFELHV------------------------------------------- 834

  Fly  1546 KRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLK 1610
                                                           .|....|.|.:.|     
Human   835 -----------------------------------------------LCKQYRHINNFQL----- 847

  Fly  1611 SFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPII 1675
                                                                             
Human   848 ----------------------------------------------------------------- 847

  Fly  1676 SEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLD 1740
                    |..|| .|.||.:.:..:|.:||..|.||::|:|.|.|||:||..|.:|.|.|||||
Human   848 --------DMDLI-LDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLD 903

  Fly  1741 GSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRI 1805
            |.|::.:|..|::.||.|..||.|:|||::||:|||||.|:.||.:|.|.||..|.||:|||||:
Human   904 GKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRV 968

  Fly  1806 GQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDES 1870
            |||::|.:.:|:|:.|||.::||...||..|.                   :|:.|::  |.||.
Human   969 GQTKEVLVIKLISQGTIEESMLKINQQKLKLE-------------------QDMTTVD--EGDEG 1012

  Fly  1871 S 1871
            |
Human  1013 S 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
domNP_001286676.1 HSA 543..614 CDD:214727 6/30 (20%)
HepA 692..>1235 CDD:440319 184/591 (31%)
DEXQc_SRCAP 949..1171 CDD:350761 105/226 (46%)
SF2_C_SNF 1685..1817 CDD:350180 66/131 (50%)
DISARM_DrmD_b <1702..>1936 CDD:468472 77/170 (45%)
HEC1 <1858..>2031 CDD:444066 6/14 (43%)
SP1-4_N 2486..>2819 CDD:425404
SMARCAD1NP_001121901.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..82
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..251 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 302..328 6/38 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..373 6/18 (33%)
HepA <496..999 CDD:440319 228/893 (26%)
DEGH box 628..631 2/2 (100%)
Nuclear localization signal. /evidence=ECO:0000255 721..738 9/16 (56%)
DEGD box 1007..1010 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

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