DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dom and INO80

DIOPT Version :9

Sequence 1:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster
Sequence 2:	NP_060023.1	Gene:	INO80 / 54617	HGNCID:	26956	Length:	1556	Species:	Homo sapiens

Alignment Length:	1510	Identity:	408/1510 - (27%)
Similarity:	634/1510 - (41%)	Gaps:	413/1510 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 GLTPGTPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEP 548
            |.|.|..:||.|.:.:|.|                     |:|..|:..:..|:...:|.|
Human    82 GETSGAGSSGMLNTYSLNG---------------------VLQSESKCDKGNLYNFSKLKK---- 121

  Fly   549 SRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVA 613
                                   .|||.|:       ::......:|.:....:..:||.|.|
Human   122 -----------------------SRKWLKS-------ILLSDESSEADSQSEDDDEEELNLSR-- 154

  Fly   614 SFIAREVKSFWSNVEKLVEYK--HQTKI-EEKRKQALDQHLSFIVDQTEKFSQQ---LVEGMNKS 672
                .|:    .|:.:|.:||  ||.|. ::|..|....:.:.::...:.|.:|   |:....|.
Human   155 ----EEL----HNMLRLHKYKKLHQNKYSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKKK 211

  Fly   673 VADTPSLNSS-RLTSPKRESDDDFRPESG---SEDDEETIAKAEEDA--ADVKEEVTAL----AK 727
            ..:...|.:. :....||..|::...|..   .....:..||...||  ...|::..::    |:
Human   212 FKEEKKLKAKLKKVKKKRRRDEELSSEESPRRHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNAR 276

  Fly   728 ESEMDFDDFLNDLPPG----------YLENRDKL----MKEEQSSAIKTETPDDSDDSEFEAKEA 778
            ..::.......:||..          :|.|..||    |||.:.:|::.:  .:..::...|:..
Human   277 RRKVWLSIVKKELPKANKQKASARNLFLTNSRKLAHQCMKEVRRAALQAQ--KNCKETLPRARRL 339

  Fly   779 SDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKL--APRDPEL- 840
            :.:......|.|:.|:|  |:|.. |.||.....:::.:.:.|.:|      |||  .....||
Human   340 TKEMLLYWKKYEKVEKE--HRKRA-EKEALEQRKLDEEMREAKRQQ------RKLNFLITQTELY 395

  Fly   841 --------DSDDDSTAVDSTEESEDAATEDEEDL-STVKTDTDMEEQDEQEDGLKSL-------- 888
                    |...|....:...:.||::|:.:.|: ..|..:...|:.|......::|
Human   396 AHFMSRKRDMGHDGIQEEILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYH 460

  Fly   889 -------MADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLK 946
                   ..|.||....|.:...|..||..   ..::.:||......|..:       |.|.:..
Human   461 IHQARTRSFDEDAKESRAAALRAANKSGTG---FGESYSLANPSIRAGEDI-------PQPTIFN 515

  Fly   947 HSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVML 1011
            ..|:.||..|::||..:.|:.:|||||||||||||:|:||||||||..:..|||.||:.|:|.:.
Human   516 GKLKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLN 580

  Fly  1012 NWEMEFKKWCPGFKILTYYGSQKERKLKRVGW------TKPNAFHVCITSYKLVVQDQQSFRRKK 1070
            ||..||.::.|.||:|.|:|:..:||:.|..|      |:...|||.||||:|||||.:.|:|.|
Human   581 NWHQEFTRFVPKFKVLPYWGNPHDRKVIRRFWSQKTLYTQDAPFHVVITSYQLVVQDVKYFQRVK 645

  Fly  1071 WKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFK 1135
            |:|::|||||.:|:..|.||::||.|....||||||||:||.:.|||:|:||:||.:|.||.||.
Human   646 WQYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFN 710

  Fly  1136 EWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLY 1200
            ||||..:....|.....:|..::|||.:::||:|||:||:||.::..|.|.::.|:|::||:.||
Human   711 EWFSKDIESHAENKSAIDENQLSRLHMILKPFMLRRIKKDVENELSDKIEILMYCQLTSRQKLLY 775

  Fly  1201 EDFMSRAKTRETLQT---------GNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHT 1256
            :...::....:.||:         ....|::|::||.|||||||.:||.:.|.|||.:....:|.
Human   776 QALKNKISIEDLLQSSMGSTQQAQNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYHI 840

  Fly  1257 PRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPN 1321
            .:.:....:...|.......|.:|                                   :|..|:
Human   841 SKFIYRHGQIRVFNHSRDRWLRVL-----------------------------------SPFAPD 870

  Fly  1322 GKYR--FH---IRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINP 1381
            ...|  ||   |...|.....|.      :..|||         .|.||:..| :|.|..|..
Human   871 YIQRSLFHRKGINEESCFSFLRF------IDISPA---------EMANLMLQG-LLARWLALF-- 917

  Fly  1382 VNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFY 1446
                                         ||:.::.:|...||. .||......:.::: |.|.
Human   918 -----------------------------LSLKASYRLHQLRSW-GAPEGESHQRYLRN-KDFL- 950

  Fly  1447 LTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDL--ATHVKSTVQKQ 1509
                     .|....|:.....|.                      |::|.|  ::|.|
Human   951 ---------LGVNFPLSFPNLCSC----------------------PLLKSLVFSSHCK------ 978

  Fly  1510 SIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCM 1574
                          |...|..|                  ::::||:
Human   979 --------------AVSGYSDQ------------------VVHQRRS------------------ 993

  Fly  1575 QATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIR 1639
             ||.||:|           |          |...|.||             ..:..|.|.|..:.
Human   994 -ATSSLRR-----------C----------LLTELPSF-------------LCVASPRVTAVPLD 1023

  Fly  1640 RYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPI-------ISEMTTKFPDP------------ 1685
            .|..:.|:   ::|:|:.. ...:|..|..||:..       ::..:..||:|
Human  1024 SYCNDRSA---EYERRVLK-EGGSLAAKQCLLNGAPELAADWLNRRSQFFPEPAGGLWSIRPQNG 1084

  Fly  1686 ----------RLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLD 1740
                      .||. |.|||..:|.||.:||..||||||::|||:|:|:||.::.|..|.|:|||
Human  1085 WSFIRIPGKESLIT-DSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLD 1148

  Fly  1741 GSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRI 1805
            ||:::.:|:.::..|.....||.|:||||:||:|||||.||||||||||||||:|.||.||.||:
Human  1149 GSSKISERRDMVADFQNRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRL 1213

  Fly  1806 GQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQS----- 1865
            |||:.|.:|||:.:.|||..||::|.:|..:..|.|.||||.....|...:..|...::.
Human  1214 GQTKQVTVYRLICKGTIEERILQRAKEKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEELEKKL 1278

  Fly  1866 --EQDESSQEKSENK 1878
              .|:|..|::..|:
Human  1279 RLRQEEKRQQEETNR 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	10/70 (14%)
		ASF1_hist_chap	<674..831	CDD:304562	33/180 (18%)
		FAM176	<824..>868	CDD:291517	12/55 (22%)
		SNF2_N	952..1238	CDD:278600	141/300 (47%)
		DEXDc	969..1108	CDD:238005	79/144 (55%)
		Helicase_C	1692..1806	CDD:278689	66/113 (58%)
INO80	NP_060023.1	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D. /evidence=ECO:0000269\|PubMed:21303910	1..266		47/248 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..87		2/4 (50%)
		Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1. /evidence=ECO:0000269\|PubMed:21303910	212..526		63/334 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..249		4/29 (14%)
		DBINO	273..402	CDD:316415	28/139 (20%)
		Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2. /evidence=ECO:0000269\|PubMed:21303910	521..1556		310/985 (31%)
		SNF2_N	521..822	CDD:306645	141/300 (47%)
		SNF2_N	<1094..>1252	CDD:331286	85/158 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1283..1316		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1388..1408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1420..1461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1499..1556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188211at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010