DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dom and lds

DIOPT Version :9

Sequence 1:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster
Sequence 2:	NP_524850.2	Gene:	lds / 45894	FlyBaseID:	FBgn0002542	Length:	1061	Species:	Drosophila melanogaster

Alignment Length:	1386	Identity:	273/1386 - (19%)
Similarity:	480/1386 - (34%)	Gaps:	526/1386 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   637 TKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRES----DDDFRP 697
            :|.....|.:.......::|:|:...:   |..:...|::...:.|..:...:||    ||..||
  Fly    33 SKSSRLSKSSRPSSAGVVIDETQSEEE---ESQSSETAESEKSDESDNSQNSQESEDSEDDSVRP 94

  Fly   698 E------------SGSEDDEETIAKAEEDA--ADVKEEVTALA------KESEMDFDDFLNDLP- 741
            .            |.|||:|:.:   |:.|  ...:..:|.:.      .:||:::.|.:.:.|
  Fly    95 SARNTKRKPLGIPSDSEDEEDEL---EQRALSPSTRMSITGVRPQDLSDDDSEIEYSDEVQEGPT 156

  Fly   742 ---------PGYLENRDKLMKEEQSSAI---KTETPDDSDDSE---FEAKE------ASDDDENT 785
                     |.|.......::.:..|.|   .:|..|||..|:   ...||      :|.||:.|
  Fly   157 EAPTAEAVVPRYTTQFAGNIQNDLHSTIGAADSEVLDDSSGSDVLILSNKETPIEILSSTDDDAT 221

  Fly   786 ISKQ-------EEAEQEIDHKKE--IDELEADNDLSVEQLLAKYKSE-QPPSPKR---------- 830
            .:|:       |...:.:..:..  ...::...:||...:.|..|.: .|.:|:|
  Fly   222 TNKENMSGPPFERPSKSLSPRSSAGASVVKTSKNLSQPTIQAVLKQKTSPAAPRRSRIKSEDQKV 286

  Fly   831 ----------RKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQ-----DE 880
                      ||||.:..:: ||.:........:..|..::..:.:.|::.:..|:||     ..
  Fly   287 VSQVVYDEEMRKLAEKRVQV-SDAEKLFEKVAHKLPDKGSQIMKRIDTLRRELAMDEQWISALRV 350

  Fly   881 QEDGLKSLMA----------------DADATSGAAG------SGSTAGASGNKDDMLNDAAALAE 923
            |:..:.::..                |.|..|.|..      :|:...|:.|     |..|...|
  Fly   351 QQSNVPAVRVVKPTLNPPRAPSIDTLDWDELSEAVNEIKPVYTGAQGMATFN-----NQKALTLE 410

  Fly   924 SLQP---KGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKL--NGILADEMGLGKTIQ 983
            ||:.   ....|....|:...|..||.||..:|...|.|: :..||||  .|||||:||||||:.
  Fly   411 SLKDLHVSLEDLPGPEVLAEDPVGLKVSLMNHQKHALAWM-SWRERKLPRGGILADDMGLGKTLT 474

  Fly   984 TIALLAHLACAKG---------------------------NW----------GPHLIVVPSSVML 1011
            .|:.:  |||..|                           .|          |..|:|.|:|::.
  Fly   475 MISSV--LACKNGQEMSEGKDESSDSDSEDDKNKKRKSVTGWKSKGRKDTRRGGTLVVCPASLLR 537

  Fly  1012 NWEMEFKKWCPGFK--ILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRR---KKW 1071
            .||.|.:......|  :..::|:.:|.|.|.:     ..:.:.:|:|::|.::.:|...   .||
  Fly   538 QWESEVESKVSRQKLTVCVHHGNNRETKGKYL-----RDYDIVVTTYQIVAREHKSLSAVFGVKW 597

  Fly  1072 KYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKE 1136
            :.:|||||..::|.|||....:.:...:.|..|||||:||..:::::|:.||....|.....:|:
  Fly   598 RRIILDEAHVVRNHKSQSSLAVCDLRGKYRWALTGTPIQNKELDVYALLKFLRCSPFDDLHTWKK 662

  Fly  1137 WFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVE-----KQMPKKYEHVITCRLSNRQ 1196
            |..|...|   |.        .||:.:::..:|||.|.:::     ..:|.|...:|...|...:
  Fly   663 WIDNKSAG---GQ--------NRLNLLMKSLMLRRTKAQLQSDGKLNSLPNKELRLIEISLDKEE 716

  Fly  1197 RYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVC 1261
            ..:|:..|:.::|.
  Fly   717 MNVYQTVMTYSRTL--------------------------------------------------- 730

  Fly  1262 DIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRF 1326
                   |.|         .||.........:::|....|....|:|           |||.| :
  Fly   731 -------FAQ---------FLHQRAERETDFNYRSDANKPTYNQIKD-----------PNGAY-Y 767

  Fly  1327 HIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVI 1391
            .:..:.|.:|          |:...::.....::.:|        |:::         ...|.:|
  Fly   768 KMHEKFARMA----------GSKKEVKSHDILVLLLR--------LRQI---------CCHPGLI 805

  Fly  1392 NSVVTTTSSST----TASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATN 1452
            ::::....|.|    ::.|.|..:.:|         :|:|
  Fly   806 DAMLDGEESQTMGDHSSDSDTPEIDLL---------AQLN------------------------- 836

  Fly  1453 SGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTE 1517
                                   :..:|.::|.||                     ||:||
  Fly   837 -----------------------KLAITDTSTDGQ---------------------QSVAN---- 853

  Fly  1518 PEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRS-LK 1581
                  |.|                              |..|:..::.|.|     :|::: ||
  Fly   854 ------AGD------------------------------DGPPLLPDEARIA-----KASKNLLK 877

  Fly  1582 RSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLS 1646
            ||                                    .|||.   ::.||
  Fly   878 RS------------------------------------NPVFN---LHRPS-------------- 889

  Fly  1647 STHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHR 1711
                   .:| |:|.|.|:..:                                    ||.:..:
  Fly   890 -------SKI-NMVIQILKTSI------------------------------------LKSSDDK 910

  Fly  1712 VLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERF---NGDKRIFCFILSTRSGGV 1773
            .::.:|.|.:||:|...|:..|...|.|:|:..|:.||.::..|   |..||:  .:||..:|||
  Fly   911 AIVVSQWTSVLDILRDHLSKDGVATLSLNGTIPVKNRQDIVNEFNDRNNQKRV--LLLSLTAGGV 973

  Fly  1774 GINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSD 1838
            |:||.||:.::..|..|||.::||||||.:|:||.::|.||:.:...|:|..|....::|..|:|
  Fly   974 GLNLIGANHLLLLDLHWNPQLEAQAQDRIYRVGQKKNVIIYKFMCVDTVEQRIKGLQDKKLDLAD 1038

  Fly  1839 MAIEGGNFTTTYFKSSTIKDL 1859
            ..:.|...::    ..||.||
  Fly  1039 GVLTGAKVSS----KLTIDDL 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727
		ASF1_hist_chap	<674..831	CDD:304562	44/232 (19%)
		FAM176	<824..>868	CDD:291517	10/63 (16%)
		SNF2_N	952..1238	CDD:278600	82/334 (25%)
		DEXDc	969..1108	CDD:238005	49/180 (27%)
		Helicase_C	1692..1806	CDD:278689	40/116 (34%)
lds	NP_524850.2	SNF2_N	442..805	CDD:278600	100/487 (21%)
		DEXDc	459..634	CDD:238005	49/181 (27%)
		HELICc	885..1014	CDD:238034	50/188 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467173
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840