Protein Alignment dom and Ino80

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_732413.1
• Gene: Ino80 / 42314
• FlyBaseID: FBgn0289122
• Length: 1638
• Species: Drosophila melanogaster
• Alignment Length: 1600
• Identity: 417/1600 - (26%)
• Similarity: 643/1600 - (40%)
• Gaps: 499/1600 - (31%)

  Fly   488 GTPTSGSLLSPALGG---GSGTPNS----------------AAQEFSFKAKQEVYVMQRISELQR 533
            |:|.||.:....||.   |...||:                |:....:..::|:.     .|:..
  Fly   226 GSPESGEVPPSELGKYTFGDTLPNNEDDDEDGGEVDYKRELASLALDYPEEEEIE-----EEVDV 285

  Fly   534 EGLWTERRLPKLQEPSR-PKAHWDYLLEEMVWLAADFAQERKWK--------------------- 576
            || .||.::.|::...: |.|           |||  .:.|.|:
  Fly   286 EG-GTEGQVTKVRRKRKNPAA-----------LAA--RRRRIWQIMSKKESGRLQRIKSNNHKEM 336

  Fly   577 ----KNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFW---SNVEKLVEYK 634
                |..|..|||:|::    :|..:||..|....:.||    :.||:.::|   ..||:....|
  Fly   337 LANCKRVAGMCAKVVRQ----RAINSQRIMKETVWRAKR----LTREMLAYWKRYERVERDQRRK 393

  Fly   635 HQTKIEEKRKQALD--------QHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKRES 691
            .:.:.||:|||.::        :.|:|::.|||.::    ..|:|.:.
  Fly   394 QEREAEEQRKQDVELIEVKRQQRKLNFLITQTELYA----HFMSKKLG----------------- 437

  Fly   692 DDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKEEQ 756
                   .|||:|:..|.                   |::|                     ||.
  Fly   438 -------QGSEEDQLRIL-------------------SQLD---------------------EET 455

  Fly   757 SSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAKYK 821
            ::.:..:  ||.|..|.:           :..||.||..:  ::::|:..|.:      :.||.|
  Fly   456 NARLAAQ--DDYDAGEMK-----------LLAQENAEAAM--QRDLDKTRAFD------VFAKKK 499

  Fly   822 SEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLK 886
            .                              :|.|:.|.|..||:..       |.:.|.:|
  Fly   500 E------------------------------KEEEEQAQESVEDIKP-------EPRPEMKD--- 524

  Fly   887 SLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLRE 951
                                                                .|.|.:.|.:|:.
  Fly   525 ----------------------------------------------------LPQPKMFKGTLKG 537

  Fly   952 YQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEME 1016
            ||..|:.||..:.::.::||||||||||||:|:||.|.|:|...|.|||.|::.|:|.:.||:.|
  Fly   538 YQIKGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCHIAEHYGVWGPFLVISPASTLHNWQQE 602

  Fly  1017 FKKWCPGFKILTYYGSQKERKLKRVGW------TKPNAFHVCITSYKLVVQDQQSFRRKKWKYLI 1075
            ..::.|.||::.|:||..|||:.|..|      |:..:|||.||||:|||.|.:.|.|.||:|::
  Fly   603 MSRFVPDFKVVPYWGSPAERKILRQFWDQKHLHTRDASFHVVITSYQLVVSDYKYFNRIKWQYMV 667

  Fly  1076 LDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSN 1140
            |||||.||:..||||:|||.||...||||:|||:||.:.|||:|:||:||.:|.||.||.||||.
  Fly   668 LDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSK 732

  Fly  1141 PMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMS 1205
            .:....|.....:|..|:|||.:::||:|||:||:||.::..|.|.::.|.|:.||:.||.....
  Fly   733 DIESHAENKTGIDEKQISRLHMILKPFMLRRIKKDVENELSDKIEIMVYCPLTIRQKLLYRALKQ 797

  Fly  1206 RAKTRE----------TLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLV 1260
            :.:..:          |..:.:..:::|::||.|||||||.:||.|...|||.|....:..|||:
  Fly   798 KIRIEDLLHLTSGSTTTSSSSSASNLMNLVMQFRKVCNHPELFERRDARSPFFMRCAEYTIPRLI 862

  Fly  1261 CDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAP----------PRKLIEDIDTAPLP 1315
                                  |.|..:...:..:..||..          .|.|.||::.
  Fly   863 ----------------------HEEGLIHRMLPSRKHLLYNRFNIFKSEYIQRSLFEDVNV---- 901

  Fly  1316 APRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASIN 1380
                 |..:.|            .:|..:.||....:.|.|.    :..||...|||::.
  Fly   902 -----NSCFGF------------TRLCDLSVGDMVEVTLNGL----IDFLLHYRRVLEKY----- 940

  Fly  1381 PVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFF 1445
                                      |..|.......|...:|.|:..|       .:::.....
  Fly   941 --------------------------PLLAYRRFWWKKQPDSRYQLLEP-------MLENKLALD 972

  Fly  1446 YLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVK--STVQK 1508
            |:.|  ||.......|..:...:|........|.....|...::||..|:|...:.::  ..|.|
  Fly   973 YMPP--NSVLKNFIFTAMTANESSVYAFGDYFTYNMQETIEHRVIRSKILKKKTSLIEEMEDVSK 1035

  Fly  1509 QSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRC 1573
            |.:.....|.:.::.|:...||..|:
  Fly  1036 QKLEIESVEVQTKSNAKSDVKVTTLL--------------------------------------- 1061

  Fly  1574 MQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEER--------CADLKPVFANFVIYV 1630
                                              ||..|..|        |   :|:....::|.
  Fly  1062 ----------------------------------LLPEFPHRPRKPRKYVC---EPLSMPRILYD 1089

  Fly  1631 PSVCAPRIRRYVQ-NLSSTHW---QHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYD 1691
            .......:.||:. :..|..|   :|.|...:...:.:...|||..|.....:...||...:..|
  Fly  1090 LGQKVQAVHRYLYCDSRSAAWSQIRHNQCENSQGRELVSSGLALCKPHGGWSSIVVPDKETLITD 1154

  Fly  1692 CGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFN 1756
            .|||..:|.||.:||.|||||||::|||||:|:||.::.:..|.|:|||||:::..|:.::..|.
  Fly  1155 AGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLLEEYMWHRKHRYMRLDGSSKISARRDMVADFQ 1219

  Fly  1757 GDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERT 1821
            ....||.|:||||:||:|||||.||||||||||||||:|.||.||.||:|||:.|.:|||:.:.|
  Fly  1220 TRADIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGT 1284

  Fly  1822 IEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQE------------- 1873
            ||..||::|.:|..:..|.|.||||.....|...:..|...::..:.:..||
  Fly  1285 IEERILQRAREKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEEIEMKYRQEAKLQSSSPIPAAT 1349

  Fly  1874 KSENKDR-----------IVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAE 1927
            :||.|.|           .:|.|:.:..|...|.:...:.:..:  |...||..||..|.:|.:
  Fly  1350 QSERKRRHPQKDVNMGGTTIAATSATQNPDDDVPSCSSAAKRIK--LETEEDFIDVGITSSASS- 1411

  Fly  1928 VAADLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLV 1967
                 ...|.|.|..:::....|...|:.::.|.|.:.||
  Fly  1412 -----VGTDSNHPTLSQETYVPGATCVQQTEIDSENEALV 1446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	20/96 (21%)
		HepA	692..>1235	CDD:440319	170/558 (30%)
		DEXQc_SRCAP	949..1171	CDD:350761	113/227 (50%)
		SF2_C_SNF	1685..1817	CDD:350180	74/131 (56%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	101/257 (39%)
		HEC1	<1858..>2031	CDD:444066	26/133 (20%)
		SP1-4_N	2486..>2819	CDD:425404
Ino80	NP_732413.1	HepA	364..>855	CDD:440319	199/675 (29%)
		DEXQc_INO80	535..763	CDD:350760	113/227 (50%)
		SF2_C_SNF	1146..1280	CDD:350180	76/133 (57%)
		PHA03247	<1535..1637	CDD:223021