Protein Alignment dom and Hel89B

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_732097.2
• Gene: Hel89B / 41943
• FlyBaseID: FBgn0022787
• Length: 1923
• Species: Drosophila melanogaster
• Alignment Length: 1947
• Identity: 377/1947 - (19%)
• Similarity: 582/1947 - (29%)
• Gaps: 857/1947 - (44%)

  Fly   111 AHSNVSVSSSTIEASVLPPQAKRQRLDDN-------EDRTSAASIVGPAESSNI---VSSLLPAS 165
            |..:||...||       .:.:..|:.|.       :...|....:|.:|::.:   .::.:.|.
  Fly   698 AGGDVSTPGST-------SRKRTPRIGDELGGNILAQSNASLKLYLGGSEATPLDVRDANFMRAR 755

  Fly   166 VASSSEVGGLSSTALQD---------------------LNALKKRILQQKL-------------Q 196
            ::||..:|.||...:|.                     |..|......|::             :
  Fly   756 ISSSRALGALSHYLVQPAPGVVYTPQTESPTDCYTKVLLGHLNAHSAVQRIVCGLIIAFWALEDE 820

  Fly   197 ILR----NLKERHLENVSEYFY-----------LQNGGSMMDYPAWRKKTPTPQFISYSNANRID 246
            .:|    ||:|:..:.||||.|           ||..   .|:.|..|:...| ...::||..:
  Fly   821 PVRPGPPNLQEKLHQCVSEYVYYDEVAISLTRLLQEA---QDFIATLKQNKIP-INDFNNAKIL- 880

  Fly   247 QLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGTGATKGAPLDGNISNSTVKTNTQSQV 311
                                  |..|.::|.::|...:     :..||.
  Fly   881 ----------------------TLDQIEAVATTLSENL-----RSYPLK---------------- 902

  Fly   312 PSKIGSFTESTPAATESNSSTTVPGTATSGAATSTSATSAEASGNVLAVEA--EIKIPAVGATPV 374
            |..:....|...:...|...||     :..:|...||.:|.| |.:.|:..  :...|.|.....
  Fly   903 PKVLDMLEERRRSLQASYQQTT-----SEQSAYHVSAQAALA-GAICALHCLPDKLNPVVKPLME 961

  Fly   375 AISTKLPAAVVQLTQQGHIPGRPLGGRHGM--VFGQIPAPPAAVGNPSVPLV---PGGTP--LLP 432
            :|..:....:.||:.:..:        |.|  |..:.|:|.:.:.|....|:   |..||  ::|
  Fly   962 SIKREQCLQLQQLSAEFLV--------HLMDQVCDRNPSPNSKILNNLCTLLRSDPEFTPKLVMP 1018

  Fly   433 CNT-----------------SAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTGNGPAALG 480
            ..|                 ...:.||::.....|..||:      ||:.|||......|
  Fly  1019 LETLKQTPVSSEVINNCVYYGILTLALQQTVTTTNTRSGA------GGATTPTATTAPRG----- 1072

  Fly   481 GSGGLTPGTPTSGSLLSPALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKL 545
                  ||.|.:|.:||         ..:|......||:|.
  Fly  1073 ------PGRPPTGEILS---------ATNATAHIELKAQQA------------------------ 1098

  Fly   546 QEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLK 610
                                          |:..||:|             ..||...|  ..::
  Fly  1099 ------------------------------KEAEAKQC-------------RIQRLGAA--CAIE 1118

  Fly   611 RVASFIAREVKSFWSNVEKLVEYKHQT--KIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSV 673
            ::......::      :||:..::|..  |:|:..|:|.|..|..::... ....:||..|....
  Fly  1119 KLCRIFGEQI------IEKVAVFQHLMFGKVEQFVKEAYDWRLGSLLPDL-GVCNELVSSMQLIE 1176

  Fly   674 ADTPSLNSSRLTSPKRESDDDFRPESG----------SEDDEETIA-KAEEDAADVKEEVTALAK 727
            ...|.|:.:  ..|:..:   ..|..|          .......|| .||.||....:.|
  Fly  1177 TAAPHLHVA--LHPQMFA---LLPSLGFIVCHPLKAVRHMAARCIAVLAEIDACQTMQFV----- 1231

  Fly   728 ESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEA 792
                     ::||.|       .|.|.||.               .|.:.|.:..|..:|:.:
  Fly  1232 ---------VHDLLP-------LLGKIEQL---------------IERQGAIEAIERVVSRLQ-- 1263

  Fly   793 EQEIDHKKEIDELEADNDLSVEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESED 857
                  .|.:..:.    |.|..||.               |..||     |:|..:.||.
  Fly  1264 ------IKVVPYIV----LLVVPLLG---------------AMSDP-----DESVRLLSTH---- 1294

  Fly   858 AATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALA 922
                      .......:...|.:.:.|||....|..|                    .|...|.
  Fly  1295 ----------CFANLVQLMPLDGKTEQLKSDPLQARKT--------------------RDREFLD 1329

  Fly   923 ESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIAL 987
            ....||    |..|...|||..::  ||.||..|::||..:|:..|:|||.|:||||||:|||.:
  Fly  1330 YLFNPK----SIPNYKVPVPISVE--LRCYQQAGINWLWFLNKYNLHGILCDDMGLGKTLQTICI 1388

  Fly   988 LA--HLACAKGNWG--PHLIVVPSSVMLNWEMEFKKWCPGFKILT---YYGSQKER-KLKRVGWT 1044
            ||  |:.....|..  |.|::.|.::..:|..|.:|:.....:|.   |||....| ||:....|
  Fly  1389 LAGDHMHRQTANLANLPSLVICPPTLTGHWVYEVEKFLDQGSVLRPLHYYGFPVGREKLRSDIGT 1453

  Fly  1045 KPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPL 1109
            |.|   :.:.||..|.:|...|....:.|.:|||...|||.|::..:.:.......||:|:|||:
  Fly  1454 KCN---LVVASYDTVRKDIDFFSGIHFNYCVLDEGHIIKNGKTKSSKAIKRLKANHRLILSGTPI 1515

  Fly  1110 QNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNE-----TLITRLHKVIRPFLL 1169
            ||:::|||||..||||....:.::|.:.||.|:....:......|     ..:..||:.:.||||
  Fly  1516 QNNVLELWSLFDFLMPGFLGTEKQFVQRFSRPILSSRDAKSSAKEQEAGVLAMEALHRQVLPFLL 1580

  Fly  1170 RRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSR----------AKTRETLQTGNLLS---V 1221
            ||:|::|.|.:|.|....:.|.||..|..|||||.::          ..:..::.|.||.:   :
  Fly  1581 RRVKEDVLKDLPPKITQDLLCELSPLQLRLYEDFSNKHLKDCLDKLGDSSSASMVTENLSAKTHI 1645

  Fly  1222 INVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQ 1286
            ...|..|:.|||||.                                           |:|...:
  Fly  1646 FQALRYLQNVCNHPK-------------------------------------------LVLRQSE 1667

  Fly  1287 TMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPA 1351
            .:|...|                                        :||
  Fly  1668 ELTKVTS----------------------------------------QLA--------------- 1677

  Fly  1352 MRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSN 1416
                                                                          |||
  Fly  1678 --------------------------------------------------------------LSN 1680

  Fly  1417 SKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTA 1481
            |.|
  Fly  1681 SSL-------------------------------------------------------------- 1683

  Fly  1482 STTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALK 1546
                                                       :|         :....:|.|||
  Fly  1684 -------------------------------------------DD---------IEHSAKLPALK 1696

  Fly  1547 RMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKS 1611
            ::.:
  Fly  1697 QLLL------------------------------------------------------------- 1700

  Fly  1612 FEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIIS 1676
                                                                             
  Fly  1701 ----------------------------------------------------------------- 1700

  Fly  1677 EMTTKFPDPRLIQYDCG-KLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHI----Y 1736
                          ||| .:||.       .|:.||.|||.|:..|||::|..| ...|:    |
  Fly  1701 --------------DCGIGVQTE-------SVSQHRALIFCQLKAMLDIVEQDL-LRRHLPSVTY 1743

  Fly  1737 LRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDR 1801
            ||||||....|||.::..||.|..|...:|:|..||:|:||||||||||.:.||||..|.||.||
  Fly  1744 LRLDGSVPASQRQDIVNNFNSDPSIDVLLLTTMVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDR 1808

  Fly  1802 CHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSE 1866
            .|||||.:.|::|||::..::|..|:.....|.:.::..:...|.:.....:|.|.|||...:.:
  Fly  1809 AHRIGQKKVVNVYRLITRNSLEEKIMGLQKFKILTANTVVSAENASLQTMGTSQIFDLFNGGKDK 1873

  Fly  1867 QDESSQEKSENKDRIVATTTLSDTPSTVVET--EKQSLRAFEHALAAAEDEQD----VQATK 1922
            ..||      ....:..|.:...:.:|::|.  |..|    ||..   |:|.|    |||.|
  Fly  1874 GAES------GSSAVQGTASGGMSMNTIIENLPELWS----EHQY---EEEYDLGNFVQALK 1922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	7/70 (10%)
		HepA	692..>1235	CDD:440319	154/579 (27%)
		DEXQc_SRCAP	949..1171	CDD:350761	83/234 (35%)
		SF2_C_SNF	1685..1817	CDD:350180	64/136 (47%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	85/231 (37%)
		HEC1	<1858..>2031	CDD:444066	19/71 (27%)
		SP1-4_N	2486..>2819	CDD:425404
Hel89B	NP_732097.2	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		HEAT repeat	395..420	CDD:293787
		HEAT repeat	433..465	CDD:293787
		HEAT repeat	475..504	CDD:293787
		HEAT repeat	516..540	CDD:293787
		HEAT repeat	560..589	CDD:293787
		DUF3535	654..1138	CDD:463447	102/609 (17%)
		HepA	<1342..1849	CDD:440319	196/933 (21%)