DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dom and Mi-2

DIOPT Version :9

Sequence 1:NP_001286676.1 Gene:dom / 45655 FlyBaseID:FBgn0020306 Length:3233 Species:Drosophila melanogaster
Sequence 2:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster


Alignment Length:2205 Identity:419/2205 - (19%)
Similarity:668/2205 - (30%) Gaps:1011/2205 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   531 LQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKA 595
            ||:|.       ||:..|            ::|.|.|     .||::....      ..:.|.:.
  Fly   163 LQKEN-------PKIAAP------------KLVMLVA-----AKWREFCES------NPHIQQEG 197

  Fly   596 TAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEK 660
            .||.....|.  |.:.|......|.:|..|:..:..:..::..:||:.::          ::.||
  Fly   198 GAAGSGGSAG--QARSVTGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEE----------EEEEK 250

  Fly   661 FSQQLVEGMNKS----VADTPSLNSSRLTSPKRESDDDFRPESG-SEDDE----ETIAKAEEDAA 716
            ..::...|..|.    ....|:|....|...||:|.|:.:..|| ||.|.    |.:.:..:|:|
  Fly   251 KPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSA 315

  Fly   717 DVKE-EVTALAKESEMDFDDFLNDLPPGYLENRDKLMK--EEQSSAIKTETPDDSDDSEFE---- 774
            |.|| .|::.|..|.....|..:..|....:.:.|:..  ::::...||:...:.:|.|.|    
  Fly   316 DEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQDY 380

  Fly   775 -----------------------------------------------AKEASDDDE--------- 783
                                                           |.|..||||         
  Fly   381 CEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCK 445

  Fly   784 ------------------------NTI----------------SKQEE------AEQEID----- 797
                                    :||                .|.|:      |::..|     
  Fly   446 DGGELLCCDSCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPST 510

  Fly   798 ------------------------HKKEIDELEAD--NDLSVEQLLAKYKSEQPP--------SP 828
                                    |.:.:.|::.|  :.|.:.....||..|:||        :.
  Fly   511 SKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESLDEAD 575

  Fly   829 KRRKLAPRDPE---LDSDDDSTAVD-------------------STEESEDAAT-------EDEE 864
            .|.|...|..:   :.::||:..::                   :...:.|.:|       |...
  Fly   576 TRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPY 640

  Fly   865 DLSTVKTDTDMEEQDEQEDGLKSLM-----ADADATSGAAGSGSTAGASGNK------DDMLNDA 918
            |.||      .||:.:...||:..:     ..|..||....|.|.....|.|      ||  .|.
  Fly   641 DKST------WEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDD--EDR 697

  Fly   919 AALAESLQPKGNTLSSTNVVTPVPFLLKHS---LREYQHIGLDWLVTMNERKLNGILADEMGLGK 980
            .....:..|:..|..........|..|:.:   |..||..|::||.....:.::.||||||||||
  Fly   698 PVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGK 762

  Fly   981 TIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKER--------- 1036
            ||||:..|..|.......||.|:.||.|.::|||.||:.|.|.|..:||.|.:..|         
  Fly   763 TIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELS 827

  Fly  1037 ---------KLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQL 1092
                     |:.|:..|: ..|:|.:|||:|:..|........|..|::|||..:|:.:|:.:::
  Fly   828 FEEGAIRGSKVSRLRTTQ-YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRI 891

  Fly  1093 LLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLI 1157
            |.:::...:||||||||||:|.||:.|::||....|:..:.|:..|::..          .|..:
  Fly   892 LNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVS----------KEEQV 946

  Fly  1158 TRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQT---GNLL 1219
            .|||:::.|.:|||||.:|.|.||.|.|.::...||..|:..|:..::  |..|.|.:   |...
  Fly   947 KRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILT--KNYEALNSKSGGGSC 1009

  Fly  1220 SVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHL 1284
            |:||::|.|:|.||||.:|                                              
  Fly  1010 SLINIMMDLKKCCNHPYLF---------------------------------------------- 1028

  Fly  1285 EQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGAS 1349
                                                                             
  Fly  1029 ----------------------------------------------------------------- 1028

  Fly  1350 PAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVL 1414
                                                                             
  Fly  1029 ----------------------------------------------------------------- 1028

  Fly  1415 SNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTV 1479
                          |:.|:.|.|                 |||....:.|.|.|:          
  Fly  1029 --------------PSAAEEATT-----------------AAGGLYEINSLTKAA---------- 1052

  Fly  1480 TASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAA 1544
                                                                             
  Fly  1053 ----------------------------------------------------------------- 1052

  Fly  1545 LKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLL 1609
                                                                             
  Fly  1053 ----------------------------------------------------------------- 1052

  Fly  1610 KSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPI 1674
                                                                             
  Fly  1053 ----------------------------------------------------------------- 1052

  Fly  1675 ISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRL 1739
                              |||..:.::|:|||...||||||:|||||||:||.||....:.|.|:
  Fly  1053 ------------------GKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERI 1099

  Fly  1740 DGSTRVEQRQILMERFNG-DKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCH 1803
            ||......||..::|||. ..:.|.|:||||:||:||||..|||||.|||||||..|.||..|.|
  Fly  1100 DGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAH 1164

  Fly  1804 RIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAI------EGGNFTTTYFKSSTIKDL--F 1860
            ||||...|.|||.|:..::|..:.:.|.:|.||:.:.:      :|.|||     ...:.|:  |
  Fly  1165 RIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFT-----KQELDDILRF 1224

  Fly  1861 TMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQS-----LRAFEHALAAAEDEQDVQA 1920
            ..|...:::..:|.....|:.||  .|.|..:..:| ||:|     |.:|:.|..|.::|::.:.
  Fly  1225 GTEDLFKEDDKEEAIHYDDKAVA--ELLDRTNRGIE-EKESWANEYLSSFKVASYATKEEEEEEE 1286

  Fly  1921 TKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETG 1985
            |                                 |:.|.|.|..:....:..:..:..:..|:.|
  Fly  1287 T---------------------------------EIIKQDAENSDPAYWVKLLRHHYEQHQEDVG 1318

  Fly  1986 AAWTAEQLRAAEAELEAQKREWEANRLAAMHKEEELLKQ--ETEAEEMLTYSRKDSSNQVWISRN 2048
                                       .::.|.:.:.||  .|:...:...:.:|.||       
  Fly  1319 ---------------------------RSLGKGKRVRKQVNYTDGGVVAADTTRDDSN------- 1349

  Fly  2049 TMEQMPMWCPPTPPQDNDNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYD----- 2108
                   |      |||.::...:||..                        |..|.|.|     
  Fly  1350 -------W------QDNGSEYNSEYSAG------------------------SDEDGGDDDFDDQ 1377

  Fly  2109 -GSRRPNKMR--REDNYVPPRSLFDRPTPQ-LARLRRELK----SQRFRGSFKPNMPIPGLKPQL 2165
             |:.|..|.|  |.|         |||.|. |||:...::    :.|.|.||...:...|:.|| 
  Fly  1378 NGAERKAKRRLERRD---------DRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQ- 1432

  Fly  2166 PTKPLTEPEAM-AEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSA 2229
                    :|. ::|.|.:          |:|                                 
  Fly  1433 --------DAFNSQWLVRD----------LRG--------------------------------- 1446

  Fly  2230 RQCRWRYETHIQPREEGKVVESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRS 2294
                                   |.::..|     .|:...:|:|....   :||..:|      
  Fly  1447 -----------------------KSERNFK-----AYVSLFMRHLCEPG---ADNAETF------ 1474

  Fly  2295 RFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFGILN--YDQP---VSP---------QNI 2345
             .|.:....|.:.....| ....||:..|    :|||..:|  |..|   :.|         |::
  Fly  1475 -ADGVPREGLSRQHVLTR-IGVMSLIRKK----VQEFEHINGYYSMPELILKPCEPVRSALKQDV 1533

  Fly  2346 AAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQ---QQQPAPPPLPQQQQPQQVVQQVQQQQ 2407
            ||::|              ||.| |.|.:....|..   ....||.|.|..::.:...:..::::
  Fly  1534 AALEA--------------PPTG-GNVDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEK 1583

  Fly  2408 -----QQQQQQQQQQVVQQQLPTVSNVQQTLPVQQT------------VELVQQQPTTTT 2450
                 ::.:.:|:|:..:.:.|  .:|:|..||::.            .|:.:.:|...|
  Fly  1584 DKTSAEKSEVKQEQEAEEDKKP--GDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEET 1641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
domNP_001286676.1 HSA 543..614 CDD:214727 14/70 (20%)
ASF1_hist_chap <674..831 CDD:304562 50/309 (16%)
FAM176 <824..>868 CDD:291517 11/80 (14%)
SNF2_N 952..1238 CDD:278600 110/306 (36%)
DEXDc 969..1108 CDD:238005 57/156 (37%)
Helicase_C 1692..1806 CDD:278689 63/114 (55%)
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335 11/56 (20%)
PHD1_CHD_II 380..422 CDD:277006 0/41 (0%)
PHD2_CHD_II 440..482 CDD:277007 2/41 (5%)
CHROMO 490..558 CDD:237991 8/67 (12%)
CHROMO 615..667 CDD:214605 10/57 (18%)
SNF2_N 734..1028 CDD:278600 110/306 (36%)
DEXDc 751..907 CDD:238005 57/156 (37%)
Helicase_C 1053..1167 CDD:278689 63/113 (56%)
DUF1087 <1292..1337 CDD:283996 8/71 (11%)
DUF1086 1380..1517 CDD:283992 44/240 (18%)
CHDCT2 1756..1927 CDD:285336
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467170
Domainoid 1 1.000 47 1.000 Domainoid score I705
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.930

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