DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dom and Chd3

DIOPT Version :9

Sequence 1:	NP_001286676.1	Gene:	dom / 45655	FlyBaseID:	FBgn0020306	Length:	3233	Species:	Drosophila melanogaster
Sequence 2:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster

Alignment Length:	1089	Identity:	238/1089 - (21%)
Similarity:	343/1089 - (31%)	Gaps:	509/1089 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   915 LNDAAALAESLQP--KGN-------TLSSTNVVTPVPFLLKHS---LREYQHIGLDWLVTMNERK 967
            ||.|.||.:.|:.  ||.       |:.........|..||.:   |..:|..|:.||.....:.
  Fly   221 LNQAIALYKKLRSSNKGRQRDRPAPTIDLNKKYEDQPVFLKEAGLKLHPFQIEGVSWLRYSWGQG 285

  Fly   968 LNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGS 1032
            :..||||||||||||||:..|..|.......||.||.||.|.:.|||.|.:.|.|....:||.|.
  Fly   286 IPTILADEMGLGKTIQTVVFLYSLFKEGHCRGPFLISVPLSTLTNWERELELWAPELYCVTYVGG 350

  Fly  1033 QKER---------------KLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNI 1082
            :..|               |..|...|: ..|:|.:|||:.:..|........|..|::|||..:
  Fly   351 KTARAVIRKHEISFEEVTTKTMRENQTQ-YKFNVMLTSYEFISVDAAFLGCIDWAALVVDEAHRL 414

  Fly  1083 KNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIE 1147
            ::.:|:.:::|..:....:||||||||||:|.||:.|::||....|:..:.|:..|::..
  Fly   415 RSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTDVS----- 474

  Fly  1148 GNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSR-AKTRE 1211
                 .|..:.|||:::.|.:|||||.:|.|.||.|.|.::...||:.|:..|:..::: .|...
  Fly   475 -----KEEQVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKHILTKNFKALN 534

  Fly  1212 TLQTGNLLSVINVLMQLRKVCNHPNMFEA---RPTISPFQMDGITFHTPRLVCDIMEYDPFTQIN 1273
            ....|.:.|::|::|.|||.||||.:|.:   ..|||
  Fly   535 QKGGGRVCSLLNIMMDLRKCCNHPYLFPSAAEEATIS---------------------------- 571

  Fly  1274 LETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQR 1338
                                                          |:|.|..
  Fly   572 ----------------------------------------------PSGLYEM------------ 578

  Fly  1339 IKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTT 1403
                                                                        ||.|.
  Fly   579 ------------------------------------------------------------SSLTK 583

  Fly  1404 ASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTA 1468
            ||
  Fly   584 AS--------------------------------------------------------------- 585

  Fly  1469 SASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQEL 1533

  Fly   586 ----------------------------------------------------------------- 585

  Fly  1534 IQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMA 1598

  Fly   586 ----------------------------------------------------------------- 585

  Fly  1599 HRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQA 1663

  Fly   586 ----------------------------------------------------------------- 585

  Fly  1664 LRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAF 1728
                                         |||..:.::|:|||.:.||||:|:||||||:|||.|
  Fly   586 -----------------------------GKLDLLSKMLKQLKADNHRVLLFSQMTKMLNVLEHF 621

  Fly  1729 LNYHGHIYLRLDGSTRVEQRQILMERFNGD-KRIFCFILSTRSGGVGINLTGADTVIFYDSDWNP 1792
            |...|:.|.|:|||.:.:.||..::|||.. ...|.|:||||:||:||||..|||||.:||||||
  Fly   622 LEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATADTVIIFDSDWNP 686

  Fly  1793 TMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGG-NFTTTYFKSSTI 1856
            ..|.||..|.||:||.:.|.|||.|:..::|..|::.|..|.||:.:.:..| ...||.|....:
  Fly   687 HNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEERIMQVAKHKMMLTHLVVRPGMGGMTTNFSKDEL 751

  Fly  1857 KDL--FTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQS-----LRAFEHALAAAED 1914
            :|:  |..|...:|..| |.....|:.||  .|.|..:..:| ||:|     |.:|:.|..|.::
  Fly   752 EDILRFGTEDLFKDGKS-EAIHYDDKAVA--DLLDRTNRGIE-EKESWANEYLSSFKVASYATKE 812

  Fly  1915 EQDVQATKTAKAEVAADLAEFDE-NIPIATEDP----NAEGGPQVELSK 1958
            :.:                |.|: |......||    |..|..|.:|.|
  Fly   813 DHE----------------EHDDYNNDAENTDPFYWENLMGKSQPKLPK 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727
		ASF1_hist_chap	<674..831	CDD:304562
		FAM176	<824..>868	CDD:291517
		SNF2_N	952..1238	CDD:278600	104/301 (35%)
		DEXDc	969..1108	CDD:238005	54/153 (35%)
		Helicase_C	1692..1806	CDD:278689	63/114 (55%)
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991
		CHROMO	181..233	CDD:214605	6/11 (55%)
		SNF2_N	270..561	CDD:278600	104/301 (35%)
		DEXDc	288..440	CDD:238005	54/152 (36%)
		Helicase_C	585..700	CDD:278689	64/401 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467171
Domainoid	1	1.000	47	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930