Protein Alignment dom and brm

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Alignment Length: 1834
• Identity: 395/1834 - (21%)
• Similarity: 616/1834 - (33%)
• Gaps: 757/1834 - (41%)

  Fly   376 ISTKLPAAVVQLTQQGHIPGRPL-----------GGRHGMVFGQIPAPP---------------- 413
            ||.::..| :|..||...||.|:           |.:|.   ||.|.||
  Fly   198 ISMQMQQA-LQAAQQQPPPGPPIGPPGAPGGPPPGSQHA---GQPPVPPQQQQQPPPSAGTPPQC 258

  Fly   414 --AAVGNPSVPLVPG--------------GTPLLPCNTSAGS----TALRRPQGQNNASSGSAAA 458
              ....||..|.|||              |.||.|.....|.    ...:.||.|...|.
  Fly   259 STPPASNPYGPPVPGQKMQVAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQ----- 318

  Fly   459 SGGGGSLTPTP------LYTGNGPAALGGSG---------------GLTPGTPTSGSLLSPALGG 502
                   .|.|      |..|..|.::|.||               |..||.|....:..|  ||
  Fly   319 -------PPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQP--GG 374

  Fly   503 G-------SGTPNSAAQEFSFKAK----QEVYVMQRISELQREGLWTERRLPKLQEPSRPKAHW- 555
            |       :|.|.......:..||    ..:.::|     :||.....|...::||..|..|..
  Fly   375 GPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQ-----ERENRIAARISLRMQELQRLPATMS 434

  Fly   556 -DYLLEEMVWLAA----DFAQERKW------KKNAAKKCAKMVQKYFQDK------ATAAQRAEK 603
             |..|:..:.|.|    :|.::.:.      :::...:.|..::.|.:.|      |.|.::.||
  Fly   435 EDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEK 499

  Fly   604 AQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFI---------VDQTE 659
            .|:|:.:|                              ||:|   :||.|:         :.:..
  Fly   500 QQKLEAER------------------------------KRRQ---KHLEFLAAVLQHGKDLREFH 531

  Fly   660 KFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTA 724
            :.::..:..|||:|.:..: |:.|....::|..:..|......:|||...|..:...|.:
  Fly   532 RNNKAQLARMNKAVMNHHA-NAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKR----- 590

  Fly   725 LAKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQ 789
            ||         ||......|:.|..:::|:.:...:|                         .|:
  Fly   591 LA---------FLLSQTDEYISNLTQMVKQHKDDQMK-------------------------KKE 621

  Fly   790 EEAEQEIDHKKE---------IDELEADNDLS---VEQLLA-KYKSEQPPSPKR-RKLAPRDPEL 840
            ||.::.|..|||         |||.....|:.   |||... |...:..|..|. .:.....|..
  Fly   622 EEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGW 686

  Fly   841 DSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTA 905
            |..||..  ||...::|...:.||..:..:..||..:....::..|.|:..|..
  Fly   687 DWIDDEE--DSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKV----------- 738

  Fly   906 GASGNKDDMLNDAA----ALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNER 966
                 :||......    ::|.::..|        ||.....::..:|:|||..||:|||::...
  Fly   739 -----EDDEYRTEEQTYYSIAHTIHEK--------VVEQASIMVNGTLKEYQIKGLEWLVSLYNN 790

  Fly   967 KLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYG 1031
            .||||||||||||||||||:|:.:|...|...||:||:||.|.:.||.:||:||.|...:::|.|
  Fly   791 NLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKG 855

  Fly  1032 SQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLL-LN 1095
            |.:.|:|.: ...:...|:|.:|:|:.|::|:....:.:|||:|:||...:||...:..|:| .:
  Fly   856 SPQGRRLLQ-NQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTH 919

  Fly  1096 FSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPM--TG-MIEGNMEYNETLI 1157
            :....|||||||||||.|.|||:|::||:|.:|.|...|::||:.|.  || .:|.|.|....:|
  Fly   920 YIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILII 984

  Fly  1158 TRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQT------- 1215
            .|||||:|||||||||||||.|:|.|.|::|.|.:|..||.||:...|:.    .|.|
  Fly   985 RRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKG----VLLTDGSEKGK 1045

  Fly  1216 ---GNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETL 1277
               |...:::|.::||||:||||.||:
  Fly  1046 HGKGGAKALMNTIVQLRKLCNHPFMFQ-------------------------------------- 1072

  Fly  1278 NLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLN 1342
                 |:|:                                    ||..|
  Fly  1073 -----HIEE------------------------------------KYCDH--------------- 1081

  Fly  1343 AVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSP 1407
                                                                             
  Fly  1082 ----------------------------------------------------------------- 1081

  Fly  1408 TGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASAST 1472
                                                                             
  Fly  1082 ----------------------------------------------------------------- 1081

  Fly  1473 TTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMR 1537
                       |.|..::..|                                |.|:|.
  Fly  1082 -----------TGGHGVVSGP--------------------------------DLYRVS------ 1097

  Fly  1538 KEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNG 1602
                                                                             
  Fly  1098 ----------------------------------------------------------------- 1097

  Fly  1603 WSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPK 1667
                                                                             
  Fly  1098 ----------------------------------------------------------------- 1097

  Fly  1668 LALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYH 1732
                                     ||.:.:||:|.:||...||||:|.|||:.:.::|.:|.:.
  Fly  1098 -------------------------GKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWR 1137

  Fly  1733 GHIYLRLDGSTRVEQRQILMERFNG-DKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDA 1796
            ...||||||:|:.|.|..|:.:||. ...:|.|:||||:||:|:||..||||:.:||||||..|.
  Fly  1138 QFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDL 1202

  Fly  1797 QAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFT 1861
            |||||.|||||..:|.:.||::..::|..||..|..|..:.:..|:.|.|......|...:.|.|
  Fly  1203 QAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQT 1267

  Fly  1862 MEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKA 1926
            :...:.:|..:|.....|.::                         .:..|..|::::..|...|
  Fly  1268 ILHQDDNEEEEENEVPDDEMI-------------------------NMMIARSEEEIEIFKRMDA 1307

  Fly  1927 EVAADLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRF----------- 1980
            |             ...||.....|.:..:.:::|. ..|.|....:||:..::
  Fly  1308 E-------------RKKEDEEIHPGRERLIDESELP-DWLTKDDDEVERFHYQYDEDTILGRGSR 1358

  Fly  1981 ----VEETGAAWTAEQLRAAE--AELEAQKREWEANRLAAMHKEEELLKQETEAEEMLTYSRKDS 2039
                |:.|.:....|.|:|.:  ||.:.::.|.::.|.....|..   |:|::.:.::...|:..
  Fly  1359 QRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNR---KEESDDDSLILKRRRRQ 1420

  Fly  2040 SNQVWISRNTMEQM 2053
            :    :.:.:.:||
  Fly  1421 N----LDKRSKKQM 1430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	19/88 (22%)
		HepA	692..>1235	CDD:440319	187/574 (33%)
		DEXQc_SRCAP	949..1171	CDD:350761	106/225 (47%)
		SF2_C_SNF	1685..1817	CDD:350180	63/132 (48%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	79/234 (34%)
		HEC1	<1858..>2031	CDD:444066	30/189 (16%)
		SP1-4_N	2486..>2819	CDD:425404
brm	NP_001261906.1	QLQ	173..202	CDD:462622	2/3 (67%)
		Pro-rich	<247..401	CDD:464580	35/167 (21%)
		PTZ00121	<477..651	CDD:173412	46/246 (19%)
		HSA	501..573	CDD:214727	17/105 (16%)
		BRK	650..691	CDD:462196	9/40 (23%)
		PLN03142	739..>1368	CDD:215601	250/1108 (23%)
		Bromo_SNF2L2	1425..1530	CDD:99947	2/6 (33%)