Protein Alignment dom and Iswi

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_523719.1
• Gene: Iswi / 36390
• FlyBaseID: FBgn0011604
• Length: 1027
• Species: Drosophila melanogaster
• Alignment Length: 1724
• Identity: 372/1724 - (21%)
• Similarity: 560/1724 - (32%)
• Gaps: 772/1724 - (44%)

  Fly   761 KTETPDDSDDSEFEAKEASDDDEN------TISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAK 819
            ||:|         .|.||::::.|      ..|...|.|.|.|:|     :|||.....:.||.:
  Fly     3 KTDT---------AAVEATEENSNETTSDAATSSSGEKEAEFDNK-----IEADRSRRFDFLLKQ 53

  Fly   820 YK---------SEQPPSPKRR--KLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDT 873
            .:         ::.|..||.|  |:..:|.|.|..|          .....||.|||
  Fly    54 TEIFTHFMTNSAKSPTKPKGRPKKIKDKDKEKDVAD----------HRHRKTEQEED-------- 100

  Fly   874 DMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVV 938
                        :.|:|:..||               |:....||:
  Fly   101 ------------EELLAEDSAT---------------KEIFRFDAS------------------- 119

  Fly   939 TPVPFLLKH-SLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHL 1002
               |..:|. .:|:||..||:|::::.|..:|||||||||||||:|||:||.:|...|...|||:
  Fly   120 ---PAYIKSGEMRDYQIRGLNWMISLYENGINGILADEMGLGKTLQTISLLGYLKHFKNQAGPHI 181

  Fly  1003 IVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFR 1067
            ::||.|.:.||..|||||||..:.:...|.|..|.........|..:.||:|||::.::::..|:
  Fly   182 VIVPKSTLQNWVNEFKKWCPSLRAVCLIGDQDTRNTFIRDVLMPGEWDVCVTSYEMCIREKSVFK 246

  Fly  1068 RKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHR 1132
            :..|:||::|||..|||.||:..::|..|.|..|||:|||||||:|.|||:|::||:|.||:|..
  Fly   247 KFNWRYLVIDEAHRIKNEKSKLSEILREFKTANRLLITGTPLQNNLHELWALLNFLLPDVFNSSE 311

  Fly  1133 EFKEWF-SNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQ 1196
            :|.||| :|...|        ::.||||||.|::||||||||.||||::..|.|..|...||..|
  Fly   312 DFDEWFNTNTCLG--------DDALITRLHAVLKPFLLRRLKAEVEKRLKPKKEMKIFVGLSKMQ 368

  Fly  1197 RYLYE-------DFMSRAKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITF 1254
            |..|.       |.::.|...|.::      :.|:||||||..|||.:|:
  Fly   369 RDWYTKVLLKDIDVVNGAGKVEKMR------LQNILMQLRKCTNHPYLFD--------------- 412

  Fly  1255 HTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRC 1319
                                                                             
  Fly   413 ----------------------------------------------------------------- 412

  Fly  1320 PNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNM 1384
                                       ||.|
  Fly   413 ---------------------------GAEP---------------------------------- 416

  Fly  1385 ALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTP 1449
                                                                    |.|:
  Fly   417 --------------------------------------------------------GPPY----- 420

  Fly  1450 ATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANG 1514
                                       ||.|
  Fly   421 ---------------------------TTDT---------------------------------- 424

  Fly  1515 KTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRS 1579
                                                                             
  Fly   425 ----------------------------------------------------------------- 424

  Fly  1580 LKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQN 1644
                                       ||:
  Fly   425 ---------------------------HLV----------------------------------- 427

  Fly  1645 LSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNG 1709
                                                         |:.||:..:|:||.:|:..|
  Fly   428 ---------------------------------------------YNSGKMAILDKLLPKLQEQG 447

  Fly  1710 HRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRI-FCFILSTRSGGV 1773
            .|||||:|||:|||:||.:.::..:.|.||||.|..|.|...::.||.|... |.|:||||:||:
  Fly   448 SRVLIFSQMTRMLDILEDYCHWRNYNYCRLDGQTPHEDRNRQIQEFNMDNSAKFLFMLSTRAGGL 512

  Fly  1774 GINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSD 1838
            ||||..||.||.|||||||.||.||.||.|||||.:.|.::||::|.|:|..|:::|..|..|..
  Fly   513 GINLATADVVIIYDSDWNPQMDLQAMDRAHRIGQKKQVRVFRLITESTVEEKIVERAEVKLRLDK 577

  Fly  1839 MAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLR 1903
            |.|:||.                :..:..::.::::..|..|..|....|...:.:.:.:
  Fly   578 MVIQGGR----------------LVDNRSNQLNKDEMLNIIRFGANQVFSSKETDITDED----- 621

  Fly  1904 AFEHALAAAEDEQDVQATKTAKAEVAAD-LAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLV 1967
             .:..|...|       .|||:.:.|.| |.|  .::...|.|.|.|.|
  Fly   622 -IDVILERGE-------AKTAEQKAALDSLGE--SSLRTFTMDTNGEAG---------------- 660

  Fly  1968 KQLSPIERYAMRFVEETGAAWTAEQ-LRAAEAELEAQKREWEANRLAAMHKEEELLKQETEAEEM 2031
              .|.:.::       .|..|..:| |.|....:|..|||.:||.....:..|.|...|.:|.:
  Fly   661 --TSSVYQF-------EGEDWREKQKLNALGNWIEPPKRERKANYAVDAYFREALRVSEPKAPK- 715

  Fly  2032 LTYSRKDSSNQVWISRNTMEQMPMWCPPTPPQDNDNDIYIDYSL--SFMYELEPIAETDLPPVYV 2094
                                      .|.||:   ..|..|:..  ..::||     .|....|.
  Fly   716 --------------------------APRPPK---QPIVQDFQFFPPRLFEL-----LDQEIYYF 746

  Fly  2095 RKE--HK-RSRTDAGYDGSRRPNKMRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNM 2156
            ||.  :| ...|:.|.|.::...:.:|:.:...|.      |.:..:.:..|.||.|....|.:.
  Fly   747 RKTVGYKVPKNTELGSDATKVQREEQRKIDEAEPL------TEEEIQEKENLLSQGFTAWTKRDF 805

  Fly  2157 -------------PIPGLKPQLPTKPLTEPEAMAEW-CVFEDMAILHVLVNLQGLPCSLMLLSPG 2207
                         .|..:...:..|   .||.:.|: .||
  Fly   806 NQFIKANEKYGRDDIDNIAKDVEGK---TPEEVIEYNAVF------------------------- 842

  Fly  2208 QTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESPKKQKKLKPTL--RTEYLKSP 2270
                |:..:|:            |...|....|: |.|||:    :::..:|..|  :....::|
  Fly   843 ----WERCTEL------------QDIERIMGQIE-RGEGKI----QRRLSIKKALDQKMSRYRAP 886

  Fly  2271 LRYLRTTQLYVSDNNASFYKTMRSRF----------------DSIKTAYLKKAPPPKRQF----- 2314
            ...||   |...:|....|..:..||                :.::.|.  :|.|   ||
  Fly   887 FHQLR---LQYGNNKGKNYTEIEDRFLVCMLHKLGFDKENVYEELRAAI--RASP---QFRFDWF 943

  Fly  2315 --SAPSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQ 2377
              |..:|...:....|...        :..:||      ::.||:|.::..:.|.| .|......
  Fly   944 IKSRTALELQRRCNTLITL--------IERENI------ELEEKERAEKKKKAPKG-SVSAGSGS 993

  Fly  2378 QSQQQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQ 2411
            .|.....|||.|...|::..:||......:::::
  Fly   994 ASSNTPAPAPQPKASQKRKSEVVATSSNSKKKKK 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727
		HepA	692..>1235	CDD:440319	172/499 (34%)
		DEXQc_SRCAP	949..1171	CDD:350761	104/222 (47%)
		SF2_C_SNF	1685..1817	CDD:350180	68/132 (52%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	88/235 (37%)
		HEC1	<1858..>2031	CDD:444066	34/174 (20%)
		SP1-4_N	2486..>2819	CDD:425404
Iswi	NP_523719.1	PLN03142	46..967	CDD:215601	340/1598 (21%)