Protein Alignment dom and swr1

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_001342781.1
• Gene: swr1 / 3361561
• PomBaseID: SPAC11E3.01C
• Length: 1288
• Species: Schizosaccharomyces pombe
• Alignment Length: 1587
• Identity: 534/1587 - (33%)
• Similarity: 766/1587 - (48%)
• Gaps: 457/1587 - (28%)

  Fly   499 ALGGGSGTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQE-PSR---PKAHWDYLL 559
            :|..|...|.. |:|..|:   ||.:..||:|.:::|.:|.....:|:: ||.   |.::.|.||
pombe    62 SLEDGDHDPKE-AKELVFR---EVQLRHRINEFRKKGYFTAEAPVELKKAPSSNNIPISYRDNLL 122

  Fly   560 EEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFW 624
            ..:...|.....:||.:.:.:::.:.|:..:|:..:.|.::..|.::.:::.:|...|.|::..|
pombe   123 SHVNGYARSMHNDRKVRASRSRRISGMILAHFKRLSGADEKKAKEEDKRIRLLAKRTAWEIRKKW 187

  Fly   625 SNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRLTSPKR 689
            ..:|:.|..:...:..|.::.|..:.|:.|:    |.|..|:|
pombe   188 KVIEREVRRRRAERAAEAQRVAGKEQLANIL----KHSTDLLE---------------------- 226

  Fly   690 ESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKE 754
                                 |..:.|::  .::|...||.:|: ::|       |:..|.|:..
pombe   227 ---------------------ARIERANI--NISAQTSESAVDW-NYL-------LKTSDDLLSV 260

  Fly   755 EQSSAIKTETPD--DSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLL 817
            ::.. :|...||  .:.:.|.||:|.| |||...|:.||.|              |.|::.|..|
pombe   261 DELK-LKYSNPDLIKNIEREEEAEETS-DDEPLSSEDEENE--------------DEDITEESNL 309

  Fly   818 AKYK--------SEQPPSPK--RRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLST-VKT 871
            .|.|        ::.|||.:  ||..|.:.....||.|...:          ...:||::. |.|
pombe   310 RKRKVSDKTRVVNKHPPSLRRSRRFFAKKSYNHVSDLDGEVI----------VMKKEDITDGVST 364

  Fly   872 DTDMEEQDEQEDGLK--------SLMADADATS---------GAAGSGSTAGAS-GNKDDMLNDA 918
            ..|:.:.|:.|..|.        ||:.:.|..|         |.|...|.||.| ..|.|
pombe   365 KKDLNDGDQNEVPLHDTGSSSSLSLLYNEDVASKKKRRVNDDGLARKKSIAGISEQRKFD----- 424

  Fly   919 AALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQ 983
                   :|.|:.:...|.: .||||.:.:|||||..||:||..:::...|||||||||||||||
pombe   425 -------EPNGSPVLHANKI-QVPFLFRGTLREYQQYGLEWLTALHDSNTNGILADEMGLGKTIQ 481

  Fly   984 TIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNA 1048
            ||||||||||.|.|||||||:||:||||||||||||:.||||||||||:.:|||.||.||.||:.
pombe   482 TIALLAHLACEKENWGPHLIIVPTSVMLNWEMEFKKFLPGFKILTYYGNPQERKEKRSGWYKPDT 546

  Fly  1049 FHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDL 1113
            :|||||||:||:||.|.||||||:|:|||||.|||||:|||||.||||:.|.|||||||||||:|
pombe   547 WHVCITSYQLVLQDHQPFRRKKWQYMILDEAHNIKNFRSQRWQSLLNFNAEHRLLLTGTPLQNNL 611

  Fly  1114 MELWSLMHFLMP-------YVFSSHREFKEWFSNPMTGMIEGNMEYNE---TLITRLHKVIRPFL 1168
            :|||||::||||       ..|::.::|::|||.||..:||...:.|.   ..:.:||:|:||:|
pombe   612 VELWSLLYFLMPAGVTQNNSAFANLKDFQDWFSKPMDRLIEEGQDMNPEAMNTVAKLHRVLRPYL 676

  Fly  1169 LRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTGNLLSVINVLMQLRKVCN 1233
            |||||.|||||||.|||||:.|:||.|||:||:||::||:|||.|.:||.:|:||.|||||||||
pombe   677 LRRLKTEVEKQMPAKYEHVVYCQLSKRQRFLYDDFINRARTREILASGNFMSIINCLMQLRKVCN 741

  Fly  1234 HPNMFEARPTISPFQMDGITFHTPRLVCD-----------IMEYDPFTQINLETLNLLLLHLEQT 1287
            |||:.|.||.::.|.:      ....:.|           ::..:|.|:::|.||.|:....| .
pombe   742 HPNLHEERPIVTSFAL------RRSAIADLEIKDLLVRKRLLHEEPMTKLDLSTLRLIRTDSE-A 799

  Fly  1288 MTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAM 1352
            ...:||.:...|                   |....|
pombe   800 FDTFVSDELNSL-------------------CATNAY---------------------------- 817

  Fly  1353 RLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNS 1417
                                .|:|..:
pombe   818 --------------------NRISTFL-------------------------------------- 824

  Fly  1418 KLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTAS 1482
                 |.||:           ::.||
pombe   825 -----RMQID-----------EECKP--------------------------------------- 834

  Fly  1483 TTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKR 1547
                             ...|.:..|:...|               |:.       :::|..|..
pombe   835 -----------------CQFKKSNFKEHFQN---------------KIY-------QEQLDKLNF 860

  Fly  1548 MAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTW----------QTRGYANCCTAMAHRNG 1602
            ...:|..:...:||||.:.....::..:.:.|:..:.:          .|:...:|
pombe   861 QKYLNESKCSHSPIYGSNLIRLAEKLPKHSTSIDYTLYAKDDPLYLLNTTKALRSC--------- 916

  Fly  1603 WSLNHLLKSFEERCADLKPVFANF--------VIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENI 1659
                  :.|.|||.:::|.:...|        |:.:|.:....|.|                 ::
pombe   917 ------ILSTEERASNMKEIIQRFACITPKAVVVDLPELFCKTIPR-----------------DL 958

  Fly  1660 VDQALRPKLALLHPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDV 1724
            :.:..| |:..||...:.:...|||.||:||||||||.:||||:.|..|||||||||||||:||:
pombe   959 LYEVSR-KINPLHQASTRLAIAFPDKRLLQYDCGKLQVLDRLLKDLVSNGHRVLIFTQMTKVLDI 1022

  Fly  1725 LEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSD 1789
            ||.|||.|||.||||||:|::||||||.||||.|.:|..|||||||||:||||||||||||||||
pombe  1023 LEQFLNIHGHRYLRLDGATKIEQRQILTERFNNDDKIPVFILSTRSGGLGINLTGADTVIFYDSD 1087

  Fly  1790 WNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSS 1854
            |||.:|||||||.||||||||||||||:||.|:|.|:|::|||||||..:.|:||.|||.:|:.:
pombe  1088 WNPQLDAQAQDRSHRIGQTRDVHIYRLISEYTVESNMLRRANQKRMLDKIVIQGGEFTTEWFRKA 1152

  Fly  1855 TIKDLFTMEQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQ 1919
            .:.|||.::    |||.::...:          ||:.||..|..      :|.||||||||:|||
pombe  1153 DVLDLFDLD----DESLKKVKAD----------SDSGSTKNEEN------WEVALAAAEDEEDVQ 1197

  Fly  1920 ATKTAKAEVAADLAEFDE-----------NIPIATED--PNAEGGPQVELS--------KADLEM 1963
            |.:.|:.|.|.:..||.|           :.|::::.  |..|.....|.|        :::||
pombe  1198 AAQVARKESALEQTEFSETSTPQAMLTKDSTPLSSDSATPGFERDSTEEQSNTNDMDEDRSELE- 1261

  Fly  1964 QNLVKQLSPIERYAMRFVEETGAA--W 1988
            ::|.:.:..|:.|.:.|:|:.|.:  |
pombe  1262 EDLDETVGHIDEYMISFLEQEGTSDEW 1288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	14/74 (19%)
		HepA	692..>1235	CDD:440319	265/583 (45%)
		DEXQc_SRCAP	949..1171	CDD:350761	152/231 (66%)
		SF2_C_SNF	1685..1817	CDD:350180	105/131 (80%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	141/233 (61%)
		HEC1	<1858..>2031	CDD:444066	44/154 (29%)
		SP1-4_N	2486..>2819	CDD:425404
swr1	NP_001342781.1	HSA	116..178	CDD:462194	11/61 (18%)
		HepA	<432..1134	CDD:440319	378/941 (40%)
		DEXQc_SRCAP	447..679	CDD:350761	152/231 (66%)