|
Fly 9 GGHEGLSPAPPAVPDRVTP------------HSTEISVAPANSTSTTVRA--------------- 46
||::.::.||..:|:..:| |.:...:...:..|..|:.
Rat 83 GGNQQITLAPLPLPNPTSPGFQFGAQQRRFEHGSPSYIQVTSPLSQQVQTQSPTQPNPGPGQTLQ 147
Fly 47 ---AGSVGAAL------------------------PATRHHQHIATQVKGIASSSSKQQKQLASA 84
||:.|..| |::..| .:..:..|:...:...|.||..:
Rat 148 NVRAGAPGPGLGICSSSPTGGFVDASVLVRQISLSPSSGGH-FVFQEAPGLTQMAQGAQVQLQHS 211
Fly 85 QLPVPLSP--LPQQQQQT----------AEATAAA------AAPAHSNVSVSSSTIEASVLPPQ- 130
..|:.:.. |.|...|: :.|||.. |:|.| |..:.||||
Rat 212 GAPITVRERRLSQPHAQSGGTIHHLGPQSPATAGGTGLQPLASPNH---------ITTASLPPQI 267
Fly 131 ---------AKRQRLDDNE--------DRTSAASI--VGPAESSNIVSSLLPASVASSSEVGGLS 176
.::|::...: :||....: ||...:..:.|...|.|.:.::...|||
Rat 268 SSIIQGQLIQQQQQVLQGQPMNRSLGFERTPGVLLPGVGGPSAFGMTSPPPPTSPSRTTMPPGLS 332
Fly 177 STAL----------------------QDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQN-G 218
|..| |::..::|:.|....:.:..|||...|.:.|.|:||: .
Rat 333 SVPLTSMGSSGIKKVPKKLEEIPPASQEMAQMRKQCLDYHYKEMEALKEVFKEYLIELFFLQHLQ 397
Fly 219 GSMMDYPAWRKKTPTPQFISYSNANRID---------------QLIHED---------------- 252
|:|||:.|::||...| ..:|...|.:| ::|:::
Rat 398 GNMMDFLAFKKKHYAP-LQAYLRQNDLDIEEEEEEEEEEEEKSEVINDEVKVVTGKDGQTGTPVA 461
Fly 253 ----KPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIGT--------------------------- 286
.|...:||.::|.|.: |..::..|||.|.|:
Rat 462 IATQLPPNVSAAFSSQQQPF---QHQALTGSLVVGPGSTTEADPFKRQQVMPPTEQSKRPRLEVG 523
Fly 287 ---------GATKGAPL-------DGNISNSTVKTNTQSQVPSKIGSFTESTPAATESNSS---- 331
|...|.|| .|.:..:...|....|..|: ..:..||....::.:|
Rat 524 HPGVVFQHPGVNAGVPLQQLMPTVQGGMPPTPQATQLTGQKQSQ-QQYDPSTGPPVQNAASLHTP 587
Fly 332 ----------TTVPGTATSGAATSTSATSAEASGNVLAVEA--EIKIPAV-----GATPVAISTK 379
.:||.| |..||...|.::. .||| :::||.. ...|..:.::
Rat 588 PPQLPARLPPASVPAT----ALPSTLQFSQQSQ----MVEAPTQLQIPVKTQQLNAPIPAPLPSQ 644
Fly 380 LPAAVVQLTQQG-HIPGRPLGGRHGMVFGQIPAPPAAVGNPSVPLVPGGTPLLPCNTSAGSTALR 443
|||...|..|.. |: .:.|:..|...|:.:....|.:...|| ....||..|..:
Rat 645 LPAPSSQPAQPALHV---SMPGKAQMQTSQLSSQTQTVASTRPPL----ESAQPCQRSLPT---- 698
Fly 444 RPQGQNNASSGSAAASGGGGSLTPTPLYTGNGPA-----ALGGSGGLTPGTPTSG--SLLSPALG 501
:::||.....||.|...:|......|.|: ||......:||...|. ...|||..
Rat 699 -----SSSSSSLVPVSGSGPGPSPARSSPVNRPSSATNKALSPVTSRSPGVAVSAPPKPQSPAQN 758
Fly 502 GGS---GTPNSAAQEFSFKAKQEVYVMQRISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMV 563
..| |:.:..|::.:. |..:.|||::|::||||:.||||||||..|||:|||||||||.
Rat 759 AASSQDGSQDKLAEQITL----ENQIHQRIADLRKEGLWSLRRLPKLQEAPRPKSHWDYLLEEMQ 819
Fly 564 WLAADFAQERKWKKNAAKKCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVE 628
|:|.||||||:||..||||..:.|.::.::|....:|.:|.::.:|:|:|:..|||::.||||:|
Rat 820 WMATDFAQERRWKLAAAKKLVRTVARHHEEKKLREERGKKEEQSRLRRIAATTAREIEYFWSNIE 884
Fly 629 KLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQLVEGMNKSVADTPSLNSSRL----TSPKR 689
::||.|.|.::|||||:||: .:|.|::..| ||| |||
Rat 885 QVVEIKLQVELEEKRKKALN---------LQKVSRRGKE--------------SRLKGFDTSP-- 924
Fly 690 ESDDDFRPESGSEDDEETIAKAEEDAADVKEEVTALAKESEMDFDDFLNDLPPGYLENRDKLMKE 754
|..||.. :..| |.
Rat 925 --------------------------------------EHSMDLG----------ISGR----KR 937
Fly 755 EQSSAIKTETPDDSDDSEFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQLLAK 819
:.|::: .|.|.| |:|.||.::|..|..:||..|:..|..:.:|.:..|:..
Rat 938 KASTSL--------TDDEVE------DEEETIEEEEAHEGLVDHHTELSNLAKEAELPLIDLMKL 988
Fly 820 YKSEQPPS---PKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDMEEQDEQ 881
|:....|: |: ||.|.::.| ..|::||..::.|....:|..|: :...|:.
Rat 989 YEGAFLPNFQWPQ--------PEPDHEESS----GEEDAEDCPSDRESRRDSVLIDS-LFIMDQF 1040
Fly 882 EDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLK 946
: |....:.|.|..|| :.:..|:||::.|||:...:|.|....|.||.
Rat 1041 K----------------AAERMSIGKSNTKD--ITEVTAVAEAILPKGSARVTTAVKFSAPSLLY 1087
Fly 947 HSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVML 1011
.:||:||.||||||..:..:.||||||||.|||||:|.||..|||||.:|||||||:|:.|..:|
Rat 1088 GALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVVMRSCNIL 1152
Fly 1012 NWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLIL 1076
.||:|.|:||||.|.|:|.|:.:|.|.||..||:||.||:||||||...:...:|.|..||.|::
Rat 1153 KWELELKRWCPGLKTLSYVGTHRELKAKRQEWTEPNNFHICITSYKQFFRGYTAFSRVHWKCLVV 1217
Fly 1077 DEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNP 1141
||.|.:|....:.|:.:....:::||||...||.|..:|||:::|||:|.: .:.:.|.|
Rat 1218 DEMQRVKGMTERHWEAIFKLQSQQRLLLIDVPLHNTFLELWTMVHFLIPGI------SRPYLSFP 1276
Fly 1142 MTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSR 1206
:....|.|.:|...::.|||:|.:||:|||.|::||||:.:|||||:.||||:||:.||||.:.:
Rat 1277 LKAPNEENQDYYHKMVIRLHRVTQPFILRRTKRDVEKQLTRKYEHVLKCRLSSRQKALYEDVILQ 1341
Fly 1207 AKTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQ 1271
.:|:|.|::|:.:||::||.:|:::||||.:.|.|...|.:....:.:.:..|:..::|.:.:.:
Rat 1342 PRTQEALKSGHFVSVLSVLTRLQRICNHPGLVEPRVPGSSYAAGSLQYKSASLILRVLEREFWKE 1406
Fly 1272 INLETLNLLLLHLEQTMTAYVSHKSRLL---APPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSA 1333
.:|...: |:.||..:: .|::.|| ...|||:|::.|:|.|:.| |.. ::::::
Rat 1407 TDLSMFD--LIGLENKIS---RHEAELLYKKKVTRKLMEEVFTSPPPSAR-PAA-----VKLKAS 1460
Fly 1334 ELAQRIKLNAVKVGASPAMRLEGSKIM-----PMR-------NLLPSGRVLKR---VSASINPVN 1383
.|.| .|:.|..| ||..:. |.| ...|.|:|..| .:.|.||..
Rat 1461 RLFQ-----PVQYGQKP----EGRTVAFPSTHPPRMANTNASTATPQGQVRGRPPIATFSANPDT 1516
Fly 1384 MALKPVVINSVVTT-------TSSSTTASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDG 1441
.|......||..:. ||:|:||:.| ::...|.|::.:.|.|| |
Rat 1517 KAAAAPFQNSQASVGTPRHQPTSTSSTAAGP-------AHPSKLRAQTAVQASTP---------G 1565
Fly 1442 KPFFYLTP------ATNSGAAGARLTLTSKT--------------TASASTTTSR-----TTVT- 1480
.| |.| .....|...||.|||:. .||.:...|| |.||
Rat 1566 PP---LPPPQAPSLVAGQSAPPQRLVLTSQAQARLPSGEVVKIAQLASIAGPQSRVAQPETPVTL 1627
Fly 1481 --------------ASTTSGQQL-----------------IR--DPIVKDLATH---VKSTVQKQ 1509
...|:||.| :| .|:|....:. |.||:..:
Rat 1628 QFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSAPGQPYLRAPGPVVMQTVSQAGAVHSTLGSK 1692
Fly 1510 SIANGKTEPEEETEAEDPYKV-------------------------QELIQMRKEQRLAALKRMA 1549
...:|.:.....|:...|.:| :|..::.||: |.::.
Rat 1693 PPTSGPSPAPLSTQVGVPGRVAVSAMAVGEPGLASKPASPAAGPTQEEKSRLLKER----LDQIH 1753
Fly 1550 MINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQ--------TRGYANCCTAMAHRNGWSLN 1606
.||.||....|:|| |:.::.|....|..:...|. .:| |:..|:::...|
Rat 1754 FINERRCSQAPVYG---RDLLRICSLPGRRKRPLCWSLDSNLGKGPKG-ADYDTSLSKSEG---- 1810
Fly 1607 HLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALL 1671
.|:.:..:|...|:.|.......:|.|.|.....:|:...|.:....:.:. |.||......
Rat 1811 DLILTLSQRQESLQDVLDRVACVIPPVVATPPSLWVERPPSLYSSRLRALR----QCLREHTGPY 1871
Fly 1672 HPIISEMTT----KFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYH 1732
|..:.::|. :||:.||:|:|.|||:.:..||::||..|.||||.:||..|||:||.|||:|
Rat 1872 HRQLQQLTALRSLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVLMLDILEMFLNFH 1936
Fly 1733 GHIYLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQ 1797
...|:|:|.:...||||.||..||.|:||||.:|||.|...||||..||||:|||:|.||.|||:
Rat 1937 YLTYVRIDENANSEQRQELMRSFNRDRRIFCALLSTHSRATGINLVEADTVVFYDNDLNPVMDAK 2001
Fly 1798 AQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTM 1862
||:.|.|||:.:|:|||||||..:||..:||... |.::.::|.:|.:::..:....||::||.:
Rat 2002 AQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGT-KDLIREVAAQGNDYSMAFLTQRTIQELFEV 2065
Fly 1863 EQSEQDESSQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAE---------DEQDV 1918
.....|.....|:|. ...||..||.......:..|.|..||.:.| .|:.|
Rat 2066 YSPMDDAGFPVKAEE------FVVLSQEPSVSETIAPKIARPFIEALKSIECLEEDAQRSTEEAV 2124
Fly 1919 QATKTAKAEVAADLAEFDENIPIATEDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEE 1983
..:.|......:|.:.:| |:|: |:| |:.:.::||:|||:||:.::|.
Rat 2125 PGSSTVAVSSDSDGSRYD-------EEPS-----QLE------ELADFMEQLTPIEKYALNYLEL 2171
Fly 1984 TGAAWTAEQLRAAEAELEAQKREWEANRLAAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRN 2048
.......|:.|::|..:.|..::||.....|:.:.|..|:.|.|..|:|||:|:|:.:..::..:
Rat 2172 FHTTTEQEKERSSEDLVMATMKDWETRNARALQEREAQLQLEQEEAELLTYTREDAYSMEYVYED 2236
Fly 2049 T---MEQMPMWCPPTPPQDNDNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGS 2110
. .|.||:|.||||||| |||||||..:..|||..||.|..|||||||||.||.:||....|
Rat 2237 ADGQTEVMPLWTPPTPPQD-DNDIYIDSVMCLMYETTPIPEAKLPPVYVRKERKRHKTDPSAAG- 2299
Fly 2111 RRPNKMRREDNYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPT--KPLTEP 2173
|..|.|..:..|||||||||.||.:.::|||.|.|:.....|...|. .|| ||| |...||
Rat 2300 -RKKKQRHGEAVVPPRSLFDRATPGMLKIRREGKEQKKNLLLKQQTPF--AKP-LPTYVKSSGEP 2360
Fly 2174 -EAMAEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYE 2237
:...:|.:.||.|:|..:..|..||.:|.::||..||||||||::||.||:.|||::|||.|||
Rat 2361 AQDSPDWLIGEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRYE 2425
Fly 2238 THIQPREEGKVV--ESPKKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIK 2300
..|.||||||:: .:|||: .:..|.....|.|||:|:|..|.||:..:...|.|:.:|
Rat 2426 NVIIPREEGKLICEANPKKK------AQNIYKSKNNRPLRTSQIYAQDENATHTQLYTSHFELMK 2484
Fly 2301 TAYLKKAPPPKRQFSA-PSLMNPKHMEVLQEFGILNYDQPVSPQNIAAMKANKIREKQRG----Q 2360
....|::||.|..... |...||||..||.|.|| |||:|:.|..:|:::|.:|.::::. |
Rat 2485 MTAGKRSPPIKPLLGMNPFQKNPKHASVLAESGI-NYDKPLPPIQVASLRAERIAKEKKALADQQ 2548
Fly 2361 QMSQPPVGVGVVQQMQQQSQ--QQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQQQQQQQVVQQQL 2423
:..||||.....||..||.| ||||..|||.|||..| .|.|.|....|....|.|.|
Rat 2549 KAQQPPVTQPPPQQQPQQQQPPQQQQQQPPPPPQQPPP-----PVPQPQAASSQTPAGQPVVQ-- 2606
Fly 2424 PTVSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQPQ 2488
|.|....|..|||.. .:.|.|.||..:.....|.:: ..:|.:::..|..:.
Rat 2607 PQVQAQPQPPPVQAQ---SKGQATMTTVGSAAVLAGTIK----TSVTGTSIPTGTVSG------- 2657
Fly 2489 QQLRTHPGQGGQSNTQQLVKTIVG---TSSSLTAGQLQQLAQQSAVASGGQSSVSVVLTTPVQTL 2550
..:|.||.| |..|:.......:|..:...|||.:...||.|.
Rat 2658 ---------------NVIVNTIAGVPATFQSINKRLASPVAPGALTTSGGSAPAQVVHTQ----- 2702
Fly 2551 PSVVQPQIGSGAQIVSISSQTLPVNSSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQ 2615
|..:|| |..::..|.|:..||.:..|.||:....|.|.||.. |...:
Rat 2703 ----QRAVGS------------PATATTDLVSMTTTQGVRAVTSVTASAVVTTNLTPV--QTPTR 2749
Fly 2616 HQTTAVTTLNTTMLRGQRIVSTAAGNTLQQRTTAGGQ----------SIVSMPNL-GQGASPSQF 2669
...|.|:......|.|:.|...|....|:|:.....| |.|.:|.| ||..||:|.
Rat 2750 SLVTQVSQATGVQLPGKTITPAAHFQLLRQQQQQQQQQQQQQQQQQTSQVQVPQLQGQAQSPAQM 2814
Fly 2670 QTQLRLA------------AVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQL 2722
:...:|| .:|..|.....| .|.|....|...:|...|..|||.
Rat 2815 KAVGKLAPEHIIKMQKQKMQLPPQPPPPQAQ----PGPPQQPAQVQVQTAQPPQQQQSP------ 2869
Fly 2723 YRQRSLKVLQTTTQAVPSGSAGATGAT-ANLVQAGGTIIQASNMATHVTSQKVAVSGMPGTSTTV 2786
|.||...|...|..||.| |||..|..|.:..|
Rat 2870 ---------QLTTVTAPRPGALLTGTTVANLQVARLTRVPTS----------------------- 2902
Fly 2787 QAGNVVSSVQMHGQARTQFIKQMAAGKQQLQRQVVSADGTTTTTAAGDMLLVKRHNILAAQKAQQ 2851
|||.|
Rat 2903 ----------------------------QLQAQ-------------------------------- 2907
Fly 2852 ASGALFTTTTGQQQQQQQQQGQLPVAGQPQQVTQHQIASLVKASTAAAASGSSV-----NAGGVT 2911
||.|.|..|..|:.:|..| |.:..||..|...| |..|::
Rat 2908 ----------GQMQTQTPQPAQVALAKPP-----------VVSVPAAVVSSPGVTTLPMNVAGIS 2951
Fly 2912 VSATNPTVQAGSVNMTLPQLKPGSQIKVTMPNQMRH-LQMQQQLTMPRKI--SRMTQLVSASGQP 2973
|:...|...|| |..|..|..::. |:::||....:|. .::.|..:|..|.
Rat 2952 VAIGQPQKTAG-------------QTVVAQPVHVQQLLKLKQQAVQQQKAIQPQVAQGQAAVQQK 3003
Fly 2974 TATNIITTTGPQQQQQGVTVSGGGT--LPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLSN 3036
..|..|||.||||:..........| |.|..|| .||:.|...||.|:...:..:.:..
Rat 3004 LTTQQITTQGPQQKVAYAAQPALKTQFLTTPISQ------AQKLAGTQQVQTQIQVAKLPQVVQQ 3062
Fly 3037 SVTMQQIQQVMRSGQQGTLATTNLVLGKTSVG---RVIP-VSVASQANQRQTI--QVVSAASAQA 3095
...:..||||..:.||.:..|..|... |:.| ::|| |:..:|..|::.| |||:.|||..
Rat 3063 QTPVASIQQVASASQQASPQTVTLTQA-TAAGQQVQMIPTVTATAQVVQQKLIQQQVVTTASASL 3126
Fly 3096 LAAGNLRTHVAGPSIASTLKVAAPGSAGGQTTQQTLIAALQHNQRQNASPVRLQT 3150
...| |||.|. .|.|:.....|..| :.....|||:|
Rat 3127 QTPG-------GPSPAQ-----LPTSSDSPNQQPKL--------QMRVPAVRLKT 3161
| 
