Protein Alignment dom and Hltf

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_001426368.1
• Gene: Hltf / 295568
• RGDID: 1309031
• Length: 1018
• Species: Rattus norvegicus
• Alignment Length: 1425
• Identity: 271/1425 - (19%)
• Similarity: 436/1425 - (30%)
• Gaps: 608/1425 - (42%)

  Fly   561 EMVWLAADFAQERK----WKKNAAK---KCAKMVQKYFQDKATAAQRAEKAQELQLKRVASFIAR 618
            |||      |.||:    :.|||.|   .....|....:|.|.|.......:..|::.|..|.|.
  Rat    81 EMV------ALEREPNNPYDKNAIKVNNVNGNQVGHLKRDLAAALAYIMDNKLAQVEGVVPFGAS 139

  Fly   619 EV------KSFWSNVEKLVEYKHQTKIEEKRKQALDQHL---SFIVDQTEKFSQQLVEGMNKSVA 674
            ..      .:||..             ||.|:..|| ||   .|.:..|.|.....:|....|..
  Rat   140 NTFTMPLHMTFWGK-------------EENREVVLD-HLKKHGFKLGPTPKTVGSSLENTWGSGR 190

  Fly   675 DTPSLN-----SSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADV-----KEEVTA--LAK 727
            ..||.:     :.::|:.:.:::.|...|...||| .||.....:|.:.     :::..|  :|:
  Rat   191 AGPSYSRPVHVAVQMTTEQLKTEFDKLFEDLKEDD-RTIEMEPAEAVETPLLPHQKQALAWMIAR 254

  Fly   728 ESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAIKTETPDD------SDD--------------SE 772
            |:.       .:||| :.|.|:.|.....::....|.|::      :||              :.
  Rat   255 ENS-------KELPP-FWELRNDLYYNTITNFSVKERPENVHGGILADDMGLGKTLTAIAVILTN 311

  Fly   773 FEAKEASDDDENTISKQ-EEAEQEIDHKKEIDELEADN---------------------DLS--- 812
            |      ||....:.|: :|:....::|.|..:|...|                     |:|
  Rat   312 F------DDGRPLLGKRGKESHPGKEYKDETVKLRGSNTNKTTDGHSEPSACSEEPSISDVSEKS 370

  Fly   813 -VEQLLAKYKSEQPPSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDME 876
             |..|.:.:.       ||||:              :|.|||.||      .|::.|.|....|:
  Rat   371 NVSDLFSFFS-------KRRKI--------------SVQSTESSE------SEEIETSKLSQKMK 408

  Fly   877 EQDEQEDGLKSLMADADATSGAAGSGS-----------TAGASGNKDDMLNDAAALAESLQ--PK 928
            .:      ||:  ...|..|...||..           |......|..||....::.||.:  ..
  Rat   409 GK------LKN--TQLDTKSKVKGSSKIKEDTQFALALTYFGPATKKKMLKKGTSVMESSKKCDT 465

  Fly   929 GNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLAC 993
            |....:|.::.|:..|            .:|::                    ...|:|...:..
  Rat   466 GERTRTTLIICPLSVL------------SNWIL--------------------FSLISLRFFMKY 498

  Fly   994 AKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKL 1058
            .:...|.|   :.|.|.||             :..|||..   :::...|....  .:.:|:|.:
  Rat   499 TQDQIGQH---IKSEVDLN-------------LYVYYGPD---RIRDSTWLSKQ--DIILTTYNI 542

  Fly  1059 V-----VQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWS 1118
            :     .:|.......||..:||||...|:|..:|:.:.:|....|||.:|||||:||.|.:|||
  Rat   543 LTHDYGTKDNSPLHSIKWLRVILDEGHAIRNPNAQQTKAVLELEAERRWVLTGTPIQNSLKDLWS 607

  Fly  1119 LMHFLMPYVFSSHREFKEWF----SNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLKKEVEK- 1178
            |:.||....|:.    :||:    ..|:|...||.:.       ||..:|:...|||.|....|
  Rat   608 LLSFLKLKPFTD----REWWHRIIQRPVTTGDEGGLR-------RLQSLIKSITLRRTKTSKIKG 661

  Fly  1179 ----QMPKKYEHVITCRLSNRQRYLYEDFMSRAKT--RETLQTGNLLS----VINVLMQLRKVCN 1233
                ::|::...:....||..:|.:|:...:..|.  ......|.:|:    |:.:|::||::|.
  Rat   662 KPVLELPERKVFIQHITLSVEERKIYQSVKNEGKATIARYFTEGTVLAHYADVLGLLLRLRQICC 726

  Fly  1234 HPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRL 1298
            |                                               :||
  Rat   727 H-----------------------------------------------VHL-------------- 730

  Fly  1299 LAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMR 1363
                                                                             
  Rat   731 ----------------------------------------------------------------- 730

  Fly  1364 NLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINA 1428
                             |.|                 .|::|.|:                  .:
  Rat   731 -----------------PTN-----------------GTSSSDPS------------------RS 743

  Fly  1429 PTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDP 1493
            .||.::.|.:                ....:|.|:|.:....|......|.             |
  Rat   744 DTPEELRKML----------------VTKMKLILSSGSDEECSICLDSLTF-------------P 779

  Fly  1494 IVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDA 1558
            ::    ||......|..|.
  Rat   780 VI----THCAHVFCKPCIC---------------------------------------------- 794

  Fly  1559 TPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVF 1623
                     :.|||              .:.:|.|....::.:|   ::||:...|..|
  Rat   795 ---------QVIQR--------------EQPHAKCPLCRSNIHG---HNLLECPPEELA------ 827

  Fly  1624 ANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLI 1688
                      |..      .|.|...|....:|.           ||::.:| |:.||  ||.:
  Rat   828 ----------CDS------DNKSDMEWTSSSKIN-----------ALMNALI-ELRTK--DPNI- 861

  Fly  1689 QYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGS----TRVEQRQ 1749
                                  :.|:.:|.|..|.::|..|...|.::.|||||    .|||..|
  Rat   862 ----------------------KSLVVSQFTTFLSLIETPLKASGFVFTRLDGSMAQKKRVESIQ 904

  Fly  1750 ILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIY 1814
            .......|...|  .:||.::||||:||..|..|...|..|||..:.|..|||||:||.::|.|.
  Rat   905 CFQNTDAGSPTI--MLLSLKAGGVGLNLCAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIIT 967

  Fly  1815 RLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSEQDESSQEK 1874
            :.:.:.::|.|:||..|.||.|:     .|.|.|              ::::.||..|.|
  Rat   968 KFIVKDSVEENMLKIQNMKRELA-----AGAFGT--------------KKTDADEMKQAK 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	16/59 (27%)
		HepA	692..>1235	CDD:440319	135/628 (21%)
		DEXQc_SRCAP	949..1171	CDD:350761	54/230 (23%)
		SF2_C_SNF	1685..1817	CDD:350180	43/135 (32%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	57/177 (32%)
		HEC1	<1858..>2031	CDD:444066	4/17 (24%)
		SP1-4_N	2486..>2819	CDD:425404
Hltf	NP_001426368.1	None