Protein Alignment dom and Ttf2

DIOPT Version :10

• Sequence 1: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Sequence 2: NP_001099924.2
• Gene: Ttf2 / 295324
• RGDID: 1309145
• Length: 1142
• Species: Rattus norvegicus
• Alignment Length: 1448
• Identity: 270/1448 - (18%)
• Similarity: 456/1448 - (31%)
• Gaps: 561/1448 - (38%)

  Fly   548 PSRPKAHWDYLLEEMVWLAADFAQERKWK---------KNAAKKC----AKMVQKYFQDKATAAQ 599
            ||:|:..:..|.:....|        :||         |.|.||.    .:::.:..:.|..:..
  Rat   119 PSQPRNPFRVLNKNQKTL--------EWKQFVEGEGEIKTADKKLRENREQLLDQKKEQKPKSKC 175

  Fly   600 RAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQTEKFSQQ 664
            |.||.....|     .:.|:........|:..:::.:||  |..:....|....::..|.|. .|
  Rat   176 RMEKDPSSDL-----VVTRQSGGDGEEQEEKTKFRPKTK--ETEEMTSKQGHGEVLQGTSKV-PQ 232

  Fly   665 LVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDD----EETIAKAEEDAADVKEEVTAL 725
            :.|..::.:.:.|...|.:.|....:|.....|||..:.:    .|.:...::..||...
  Rat   233 ISESESQEIPNKPEALSEKETHLLLQSIPGQNPESKVQKEGHLIREQLKNGDKTGADAHS----- 292

  Fly   726 AKESEMDFDDFLNDLPPGYLENRDKLMKEEQSSAI-----------KTETPDDSDDS-------- 771
            |:.|:       ..|..|.|:...|..:....:.:           .|.:.|||:|.
  Rat   293 AQASQ-------TGLSQGSLQGPSKTWRPTPKARVAPGVCSGSVHHATSSSDDSEDDGRPGSPLL 350

  Fly   772 -----EFEAKEASDDDENTISKQEEAEQEIDHKKEIDELEADNDLSVEQL------LAKYKSEQP 825
                 :.:.|.:....:.::.:|..|...:..|.|..:|.|.......||      ||....:..
  Rat   351 FDLTIDSQKKGSLQHSDQSVQRQTAAASGVSKKGESSDLAAQRANLTTQLKQKKGTLAAVNIQAL 415

  Fly   826 PSPKRRKLAPRDPELDSDDDSTAVDSTEESEDAATEDEEDLSTVKTDTDM--------------- 875
            |. |..||..:...|:...::.|:...:.:.:..:..|.:.|.| |:|..
  Rat   416 PD-KGEKLLKQIQALEDALNALALSPEQGTRENCSSQEPEQSKV-TETAAAGPLHLVPPQPLPRP 478

  Fly   876 EEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTP 940
            ..|.....|||     |.......|:...:|...|:..:.|.....:|::.....:|.|....|.
  Rat   479 HIQPAASLGLK-----ASRQETPEGASQCSGGHTNEHRLYNVWKITSEAIDELHRSLESCPGKTA 538

  Fly   941 V---PFLLKHSLREYQHIGLDWLVTMNERK-LNGILADEMGLGKTIQTIALLAHLACAKGN---- 997
            |   |..||..|..:|...|.||:....:| ..|||||:||||||:..|||:    ..|.|
  Rat   539 VAEDPAGLKVPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALI----LTKKNQQKS 599

  Fly   998 ----------W------------GPHLIVVPSSVMLNWEMEFKKWCPG--FKILTYYGSQKERKL 1038
                      |            |. |||.|:|::.:|:.|.:|....  .:|..|:|..:.:..
  Rat   600 KEKDRSLPVMWLSKNDSSVFTSTGT-LIVCPASLIHHWKNEIEKRVNSNKLRIYLYHGPNRIQHA 663

  Fly  1039 KRVGWTKPNAFHVCITSYKLVVQDQQSFRRK--------------------KWKYLILDEAQNIK 1083
            |.:     :.:.:.||:|.|:.::..:.:.:                    .|..:|||||.|:|
  Rat   664 KVL-----STYDIVITTYSLLAKEIPTAKHEGEVPGAKLSVEGISAPLLQVVWARIILDEAHNVK 723

  Fly  1084 NFKSQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEG 1148
            |.:.|....:.....:.|..:||||:||:|::::|||.||....|.   ||..|.|....|.::|
  Rat   724 NPRVQTSIAVCKLQAQARWAVTGTPIQNNLLDMYSLMKFLRCSPFD---EFSLWKSQVDNGSMKG 785

  Fly  1149 NMEYNETLITRLHKVIRPFLLRRLKKEVEK------QMPKKYEHVITCRLSNRQRYLYEDFMSRA 1207
            .        .||..:.:..||||.|.:::.      .:|.:...:...:||..:|.:|:.|:  |
  Rat   786 G--------ERLSILTKSLLLRRTKDQLDSTGKPLVPLPARSCQLHRLKLSEDERAVYDVFL--A 840

  Fly  1208 KTRETLQTGNLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQI 1272
            ::|..||        :.|.:.....:||
  Rat   841 RSRSALQ--------SYLKRQEGRGSHP------------------------------------- 860

  Fly  1273 NLETLNLLLLHLEQTMTAYVSHKSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQ 1337
                                                                             
  Rat   861 ----------------------------------------------------------------- 860

  Fly  1338 RIKLNAVKVGASPAMRLEGSKIMPMRNLLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSST 1402
                     |.||.                            ||.
  Rat   861 ---------GRSPE----------------------------NPF-------------------- 868

  Fly  1403 TASSPTGALSVLSNSKLLGARSQINAPTPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTT 1467
                                         ::||:....|.|                    ..:|
  Rat   869 -----------------------------SRVAQEFGSGVP--------------------QCST 884

  Fly  1468 ASASTTTSRTTVTASTTSGQQLIRDPIVKDLATHVKSTVQKQSIANGKTEPEEETEAEDPYKVQE 1532
            |:.|...|                       ..||.|                           :
  Rat   885 AADSRRPS-----------------------TVHVLS---------------------------Q 899

  Fly  1533 LIQMRKEQRLAALKRMAMINRRRTDATPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAM 1597
            |:::|:                                                      ||..:
  Rat   900 LLRLRQ------------------------------------------------------CCCHL 910

  Fly  1598 AHRNGWSLNHLLKSFEERCADLKPVFANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQ 1662
            :         |||                     ||..|:               |...|.:| .
  Rat   911 S---------LLK---------------------SVLDPK---------------ELESEGLV-L 929

  Fly  1663 ALRPKLALLHPIISEMTTKFPDPRL-IQYDCGKLQTMDRLLRQLKVN--------------GHRV 1712
            :|..:|:.|  .:|::....|.|.: :...|.|::..|.:.|..||:              ..:.
  Rat   930 SLEEQLSAL--TLSKVDVSEPSPTVSLNGTCFKVELFDDIRRSTKVSSLLAELEAIQKGPGSQKS 992

  Fly  1713 LIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINL 1777
            :|.:|.|.||.|:...|..:...|..:|||...:||..|:|.||..:.....::|..:||||:||
  Rat   993 VIVSQWTSMLQVVALHLRKNRLTYATIDGSVNPKQRMDLVEAFNHSQGPQVMLISLLAGGVGLNL 1057

  Fly  1778 TGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIE 1842
            ||.:.:...|..|||:::.||.||.:|:||.:||.::|.|.|.|:|..||:...:|:.|:...:.
  Rat  1058 TGGNHLFLLDMHWNPSLEDQACDRIYRVGQEKDVVMHRFVCEGTVEEKILQLQEKKKDLAKQVLS 1122

  Fly  1843 GGNFTTTYFKSSTIKDLF 1860
            |.....|....:.:|.||
  Rat  1123 GSGGPVTKLTLADLKILF 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dom	NP_001286676.1	HSA	543..614	CDD:214727	16/78 (21%)
		HepA	692..>1235	CDD:440319	144/649 (22%)
		DEXQc_SRCAP	949..1171	CDD:350761	74/270 (27%)
		SF2_C_SNF	1685..1817	CDD:350180	47/146 (32%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	56/173 (32%)
		HEC1	<1858..>2031	CDD:444066	2/3 (67%)
		SP1-4_N	2486..>2819	CDD:425404
Ttf2	NP_001099924.2	zf-GRF	6..44	CDD:480736
		HepA	<536..1122	CDD:440319	184/976 (19%)
		DEXHc_TTF2	550..800	CDD:350830	74/270 (27%)